Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Susan E. Howlett"'
Autor:
Kulpreet Cheema, Taylor Dunn, Chere Chapman, Kenneth Rockwood, Susan E. Howlett, Gunes Sevinc
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Background Goal attainment scaling (GAS), an established individualized, patient-centred outcome measure, is used to capture the patient’s voice. Although first introduced ~60 years ago, there are few published guidelines for implementing
Externí odkaz:
https://doaj.org/article/408fc627820e4ec8a48a1adfd85a9f66
Autor:
Trang Tran, John Mach, Gizem Gemikonakli, Harry Wu, Heather Allore, Susan E. Howlett, Christopher B. Little, Sarah N. Hilmer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Aging, polypharmacy (concurrent use of ≥ 5 medications), and functional impairment are global healthcare challenges. However, knowledge of the age/sex-specific effects of polypharmacy is limited, particularly on daily physical activities.
Externí odkaz:
https://doaj.org/article/eb4d67e424fa4c2a8773687174f2e38a
Autor:
Kari Knox, Justin Stanley, James A. Hendrix, Hampus Hillerstrom, Taylor Dunn, Jillian Achenbach, Brian A. Chicoine, Florence Lai, Ira Lott, Sanja Stanojevic, Susan E. Howlett, Kenneth Rockwood
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background As life expectancy of people with Down syndrome (DS) increases, so does the risk of Alzheimer’s disease (AD). Identifying symptoms and tracking disease progression is especially challenging whenever levels of function vary befor
Externí odkaz:
https://doaj.org/article/a64e8a0910b64b74b56d860f0cb9fe95
Autor:
Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The discovery of interventions that slow aging could be accelerated by employing non-invasive biometrics that predict biological age or life expectancy. Here the authors use longitudinal frailty data from naturally aging mice to develop two such tool
Externí odkaz:
https://doaj.org/article/3a49ccbd63f44865818e20ab50fb5065
Publikováno v:
Biology of Sex Differences, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Background Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). While endogenous estroge
Externí odkaz:
https://doaj.org/article/d8af1febb92e4022826d1b505923e9bb
Autor:
Elise S. Bisset, Susan E. Howlett
Publikováno v:
Aging Medicine, Vol 2, Iss 1, Pp 27-34 (2019)
Abstract Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to explain the heterogeneity in rates of aging in people of the same age. Frailty has important clinical implications, because even minor stressors can
Externí odkaz:
https://doaj.org/article/f6e5bd7d2b494a0f854978c1841ed67c
Publikováno v:
Aging Medicine, Vol 2, Iss 1, Pp 11-17 (2019)
Abstract Objective Early frailty may be captured by a frailty index (FI) based entirely on vital signs and laboratory tests. Our aim was to examine associations between a laboratory‐based FI (FI‐Lab) and adverse health outcomes, and investigate h
Externí odkaz:
https://doaj.org/article/e2294eb6bfbb4dd395eca79aa300a399
Autor:
Elise S. Bisset, Susan E. Howlett
Publikováno v:
Nutrients, Vol 14, Iss 14, p 2806 (2022)
Frailty is a state of accelerated aging that increases susceptibility to adverse health outcomes. Due to its high societal and personal costs, there is growing interest in discovering beneficial interventions to attenuate frailty. Many of these inter
Externí odkaz:
https://doaj.org/article/e12c079dfcf6459fbb5f3525c90bfa2a
Autor:
Kenneth Rockwood, Susan E. Howlett
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-4 (2018)
Abstract The notion of frailty has evolved for more than 15 years. Although there is no consensus definition, frailty reflects a state of increased vulnerability to adverse health outcomes for individuals of the same chronological age. Two commonly u
Externí odkaz:
https://doaj.org/article/96ab2d2a107040c0856d28e7f1d295d2
Autor:
Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/23d4cfc253274da388621ba3d2b1f8be