Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Susan E. Crawford"'
Autor:
Alexander Glaser, Zhuqing Shi, Jun Wei, Nadia A. Lanman, Skylar Ladson-Gary, Renee E. Vickman, Omar E. Franco, Susan E. Crawford, S. Lilly Zheng, Simon W. Hayward, William B. Isaacs, Brian T. Helfand, Jianfeng Xu
Publikováno v:
European Urology Open Science, Vol 43, Iss , Pp 54-61 (2022)
Background: The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies. Objective: To assess the association between BPH and PCa usi
Externí odkaz:
https://doaj.org/article/b38eb71cdebd4aa9be17d3bfc70b3177
Autor:
Renee E. Vickman, LaTayia Aaron-Brooks, Renyuan Zhang, Nadia A. Lanman, Brittany Lapin, Victoria Gil, Max Greenberg, Takeshi Sasaki, Gregory M. Cresswell, Meaghan M. Broman, J. Sebastian Paez, Jacqueline Petkewicz, Pooja Talaty, Brian T. Helfand, Alexander P. Glaser, Chi-Hsiung Wang, Omar E. Franco, Timothy L. Ratliff, Kent L. Nastiuk, Susan E. Crawford, Simon W. Hayward
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Reduction of systemic autoimmunity using TNF blockers may also reduce inflammatory diseases in other organs. Here, the authors use a patient database and scRNA-seq to link autoimmune diseases to benign prostatic hyperplasia (BPH), and demonstrate tha
Externí odkaz:
https://doaj.org/article/572e6df1a2f4471bb53b3a820ff54a37
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-10 (2021)
Abstract Obesity is a worldwide epidemic associated with increased risk and progression of colon cancer. Here, we aimed to determine the role of adipose triglyceride lipase (ATGL), responsible for intracellular lipid droplet (LD) utilization, in obes
Externí odkaz:
https://doaj.org/article/dad0fa3c4c914a0ebba7e45d5f2c7f93
Autor:
Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad, Rebecca E. Steele, Omar E. Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E. Crawford, Luke Gaughan, Ian G. Mills, Simon W. Hayward, Craig N. Robson, Rakesh Heer
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 734-745 (2020)
Abstract Primary culture of human prostate organoids and patient‐derived xenografts is inefficient and has limited access to clinical tissues. This hampers their use for translational study to identify new treatments. To overcome this, we establish
Externí odkaz:
https://doaj.org/article/1a016c78ab2e4635979543ad1a0a990f
Autor:
Harrison M. Penrose, Chloe Cable, Sandra Heller, Nathan Ungerleider, Hani Nakhoul, Melody Baddoo, Alifiani B. Hartono, Sean B. Lee, Matthew E. Burow, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 391-408 (2019)
Background & Aims: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular c
Externí odkaz:
https://doaj.org/article/7337e8aa807f4d11a94daa9ce23793f7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7745 (2022)
The retinal pigment epithelium (RPE) expresses the Serpinf1 gene to produce pigment epithelium-derived factor (PEDF), a retinoprotective protein that is downregulated with cell senescence, aging and retinal degenerations. We determined the expression
Externí odkaz:
https://doaj.org/article/c6cd5e8742bd47999bc1367020bf8b65
Autor:
Mamatha Kakarla, Sathyavathi ChallaSivaKanaka, Mary F. Dufficy, Victoria Gil, Yana Filipovich, Renee Vickman, Susan E. Crawford, Simon W. Hayward, Omar E. Franco
Publikováno v:
Cancers, Vol 14, Iss 9, p 2336 (2022)
Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph rece
Externí odkaz:
https://doaj.org/article/2dd0f122a31b44998a28b9e8b0223adc
Autor:
Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Joshua S. Samudre, Morgan E. Collins, Alifiani B. Hartono, Sean B. Lee, Frank Lau, Melody Baddoo, Erik F. Flemington, Susan E. Crawford, Suzana D. Savkovic
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/df3e440f84514614aa5dd372b8cc26ab
Autor:
Sofia Halin, Stina Häggström Rudolfsson, Jennifer A. Doll, Susan E. Crawford, Pernilla Wikström, Anders Bergh
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 4, Pp 336-345 (2010)
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors in
Externí odkaz:
https://doaj.org/article/32d407ebc3594ede8b331d49ecfbc51a
Autor:
Petr Protiva, Jingjing Gong, Bharath Sreekumar, Richard Torres, Xuchen Zhang, Glenn S. Belinsky, Mona Cornwell, Susan E. Crawford, Yasuko Iwakiri, Chuhan Chung
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 5, Pp 535-549.e14 (2015)
Background & Aims: Pigment epithelium-derived factor (PEDF) is a secretory protein that inhibits multiple tumor types. PEDF inhibits the Wnt coreceptor, low-density lipoprotein receptor-related protein 6 (LRP6), in the eye, but whether the tumor-supp
Externí odkaz:
https://doaj.org/article/9d414f0e15fb492d9365197a7d29d708