Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Susan E. Bove"'
Autor:
Veronica Reinhart, Susan E. Bove, Dmitri Volfson, David A. Lewis, Robin J. Kleiman, Thomas A. Lanz
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 220-227 (2015)
Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of neural functions, including synaptic plasticity and exhibits activity-dependent regulation of expression. As altered BDNF signaling has been implicated in multiple psychiatr
Externí odkaz:
https://doaj.org/article/0d41d5db21884363b76e9422d51fbd34
Autor:
Dmitri Volfson, Robin J. Kleiman, David A. Lewis, Larry C. James, Veronica Reinhart, Stacey J. Sukoff Rizzo, Thomas A. Lanz, Mark J. Sheehan, Susan E. Bove
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-13 (2019)
Translational Psychiatry
Translational Psychiatry
Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) arise from complex interactions between genetic and environmental factors. Common genetic variants associated with multiple psychiatric diso
Autor:
Robin J. Kleiman, Alexander J. Hartman, Alison Romegialli, Abigail Mariga, Veronica Reinhart, Michy P. Kelly, Geetanjali Pathak, Susan E. Bove, Wendy O. Adamowicz
Publikováno v:
Cellular Signalling. 26:383-397
3',5'-cyclic nucleotide phosphodiesterases (PDEs) are the only known enzymes to compartmentalize cAMP and cGMP, yet little is known about how PDEs are dynamically regulated across the lifespan. We mapped mRNA expression of all 21 PDE isoforms in the
Autor:
Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of PDE4 inhibitors, while simultaneously minimizing PDE4 activity. These newly designed PDE2 inhibitors bind to the PDE2 enzyme in a cGMP-like mode in co
Autor:
Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain. We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of phosphodiesterase 4 (PDE4) inhi
Autor:
Gregory W Cadelina, Catherine D Pilsmaker, Sharon Carmel, Robin J. Kleiman, Jo Ann Dumin, Abigail Mariga, Wendy O. Adamowicz, Elena M. Drummond, Thomas A. Lanz, Brentt J Swetter, Susan E. Bove
Publikováno v:
Biomarkers. 17:524-531
Adult rats were treated acutely with peripheral kainic acid (KA), and changes in brain-derived neurotrophic factor (BDNF) mRNA and protein were tracked over time across multiple brain regions. Despite robust elevation in both mRNA and protein in mult
Publikováno v:
Brain Research Reviews. 60:187-201
Non-malignant musculoskeletal pain is the most common clinical symptom that causes patients to seek medical attention and is a major cause of disability in the world. Musculoskeletal pain can arise from a variety of common conditions including osteoa
Autor:
Susan E. Bove, Brian Sanchez, Kenneth S. Kilgore, Melissa Thiel, David Brammer, Mark E. Lesch
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 57:169-175
Introduction Thermal imaging has been utilized, both preclinically and clinically, as a tool for assessing inflammation and arthritis. However, previous studies have employed large, relatively immobile devises to obtain the thermal signature of the t
Autor:
Jack J. Kinsora, Jared B.J. Milbank, Rachel M. Brooker, Christopher S. Knauer, Kenneth S. Kilgore, Cleo J. C. Connolly, John A. Wendt, Corinne E. Augelli-Szafran, Koji Yamagata, Susan E. Bove, Mickelson John, Paul Galatsis, Roy D. Schwarz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6525-6528
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea