Výsledky vyhledávání - "Susan E. Bear"

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

Autor: Susan E. Bear, Sotirios C. Kampranis, Oksana B. Serebrennikova, Alexandros Tzatsos, Raymond Pfau, Philip N. Tsichlis

Publikováno v: Proceedings of the National Academy of Sciences. 105:1907-1912

A common integration site, cloned from MoMuLV-induced rat T cell lymphomas, was mapped immediately upstream of Not dead yet-1 ( Ndy1 )/ KDM2B , a gene expressed primarily in testis, spleen, and thymus, that is also known as FBXL10 or JHDM1B. Ndy1 enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5d688f8e97bf11562545e0cc96c19a
https://doi.org/10.1073/pnas.0711865105

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Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition

Autor: Kyoji Horie, Susan E. Bear, George A. Gaitanaris, Philip N. Tsichlis, Ioanna G. Maroulakou, Thomas Ludwig, Esmerina Tili, Marei Dose, Changchuin Mao, Mariëlle C. Haks, Fotini Gounari, David L. Wiest, Vincenzo Fidanza

Publikováno v: The Journal of Immunology. 178:5443-5453

Pre-TCR signals regulate the transition of the double-negative (DN) 3 thymocytes to the DN4, and subsequently to the double-positive (DP) stage. In this study, we show that pre-TCR signals activate Akt and that pharmacological inhibition of the PI3K/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9042db7e7888864a634afcb6c5c084
https://doi.org/10.4049/jimmunol.178.9.5443

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iPSC-derived fibroblasts demonstrate augmented production and assembly of extracellular matrix proteins

Autor: Elana B. Knight, Hiba Qari, Addy Alt-Holland, Yulia Shamis, Avi Smith, Kyle J. Hewitt, Jonathan A. Garlick, Mariam Margvelashvilli, Susan E. Bear

Publikováno v: In vitro cellulardevelopmental biology. Animal. 48(2)

Reprogramming of somatic cells to induced pluripotent stem cells (iPSC) provides an important cell source to derive patient-specific cells for potential therapeutic applications. However, it is not yet clear whether reprogramming through pluripotency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13c96e5d8bbb49da4f590c96e61cccb
https://pubmed.ncbi.nlm.nih.gov/22259014

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Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

Autor: Philip N. Tsichlis, C B Gilks, H L Grimes, Susan E. Bear

Publikováno v: Molecular and Cellular Biology. 13:1759-1768

During progression of Moloney murine leukemia virus (Mo-MuLV)-induced rat T cell lymphomas, growth selection results in the expansion of cell clones carrying increasing numbers of integrated proviruses. These new provirus insertions reproducibly cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f52eaf643d31b2d0bf71c34e2be984f5
https://doi.org/10.1128/mcb.13.3.1759

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Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line

Autor: Philip N. Tsichlis, Susan E. Bear

Publikováno v: Proceedings of the National Academy of Sciences. 88:4611-4615

The development of T-cell lymphomas in rodents infected with type C retroviruses has been linked to the generation of a class of envelope (env) recombinant viruses called mink cell focus-forming viruses (MCF viruses) in the preleukemic thymus. To det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4224a0baf550d2cf6b2d0ef12b93c60
https://doi.org/10.1073/pnas.88.11.4611

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The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation

Autor: Pedro A. Lazo, Alfonso Bellacosa, Philip N. Tsichlis, Susan E. Bear

Publikováno v: Europe PubMed Central

Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphomas express discrete 1.8-, 2.2-, and 4-kb mRNA transcripts hybridizing under conditions of reduced stringency to a probe derived from a region upstream of the first exon of the Tpl-1/Ets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f1a90c79f73083f5e3c5de8d9a1779
https://doi.org/10.1128/mcb.11.5.2864

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Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment

Autor: Philip N. Tsichlis, Trang Hoang, Qing Yu, Alfred Singer, Herbert C. Morse, Susan E. Bear, Sabine Herblot, Mary Kate Kitay, Loretta L. Doan, H. Leighton Grimes

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 170(5)

T cell differentiation in the thymus is dependent upon signaling through the TCR and is characterized by the resulting changes in expression patterns of CD4 and CD8 surface coreceptor molecules. Although recent studies have characterized the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45379e9e0d1d86af9c630c3d97ae0cbe
https://pubmed.ncbi.nlm.nih.gov/12594258

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The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1

Autor: Roger Brent, Antonios M. Makris, Christine McMahon, Erica A. Golemis, Susan E. Bear, Vinayaka R. Prasad, Jun Hsiang Lin, Philip N. Tsichlis, Christos Patriotis

Publikováno v: The Journal of biological chemistry. 274(21)

Tvl-1 is a 269-amino acid ankyrin repeat protein expressed primarily in thymus, lung, and testes that was identified by screening a murine T-cell two-hybrid cDNA library for proteins that associate with the serine-threonine kinase Raf-1. The interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56c6052ac63cc52e828141fb12f0d3a
https://pubmed.ncbi.nlm.nih.gov/10329666

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The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines

Autor: Susan E. Bear, Christos Patriotis, Philip N. Tsichlis, Christos Tsatsanis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 95(7)

Tpl-2expression is induced within 30–60 min after ConA stimulation of rat splenocytes, suggesting that it may contribute to the induction of IL-2 during T cell activation. Herein we show that wild-type and carboxyl-terminally truncated (activated)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a755d10b8b3de3b7278d056dcc7fc4b
https://pubmed.ncbi.nlm.nih.gov/9520452

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