Výsledky vyhledávání - "Susan E Nozell"

Akademický článek

Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer.

Autor: Sindhu Nair, Hoa Q Trummell, Rajani Rajbhandari, Nanda K Thudi, Susan E Nozell, Jason M Warram, Christopher D Willey, Eddy S Yang, William J Placzek, James A Bonner, Markus Bredel

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0229077 (2020)

Epidermal growth factor receptor (EGFR) is a pro-tumorigenic receptor tyrosine kinase that facilitates growth for cancer cells that overexpress the receptor. Monoclonal anti-EGFR antibody Cetuximab (CTX) provides significant clinical benefit in patie

Externí odkaz: https://doaj.org/article/20ddfc5b974349a48705b8719e140d9b

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Akademický článek

NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.

Autor: Braden C McFarland, Suk W Hong, Rajani Rajbhandari, George B Twitty, G Kenneth Gray, Hao Yu, Etty N Benveniste, Susan E Nozell

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78728 (2013)

Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are aberrantly activated and associated with tumor cell proliferation, surv

Externí odkaz: https://doaj.org/article/b5fc7ee2c43f4af49ac189a525edcf27

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Akademický článek

Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.

Autor: Keun W Park, Susan E Nozell, Etty N Benveniste

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50874 (2012)

The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulatin

Externí odkaz: https://doaj.org/article/ea16b5a2971844688d8942fe12f836cd

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Akademický článek

O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells.

Autor: Dongqi Xing, Kaizheng Gong, Wenguang Feng, Susan E Nozell, Yiu-Fai Chen, John C Chatham, Suzanne Oparil

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e24021 (2011)

We have shown that glucosamine (GlcN) or O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) treatment augments O-linked-N-acetylglucosamine (O-GlcNAc) protein modification and attenuates inflammatory mediator expression, le

Externí odkaz: https://doaj.org/article/a7f2dc0860774d3f89264b507a9cdf13

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