Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Susan E Moody"'
Autor:
Maria B Raeder, Even Birkeland, Jone Trovik, Camilla Krakstad, Shyemaa Shehata, Steven Schumacher, Travis I Zack, Antje Krohn, Henrica Mj Werner, Susan E Moody, Elisabeth Wik, Ingunn M Stefansson, Frederik Holst, Anne M Oyan, Pablo Tamayo, Jill P Mesirov, Karl H Kalland, Lars A Akslen, Ronald Simon, Rameen Beroukhim, Helga B Salvesen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54873 (2013)
Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most frequently included in 8q24 am
Externí odkaz:
https://doaj.org/article/2a99f9b505914829bce194a254db2ab1
Autor:
Jason R. Ruth, Dhruv K. Pant, Tien-chi Pan, Hans E. Seidel, Sanjeethan C. Baksh, Blaine A. Keister, Rita Singh, Christopher J. Sterner, Suzanne J. Bakewell, Susan E. Moody, George K. Belka, Lewis A. Chodosh
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-23 (2021)
Abstract Background Breast cancer mortality is principally due to tumor recurrence, which can occur following extended periods of clinical remission that may last decades. While clinical latency has been postulated to reflect the ability of residual
Externí odkaz:
https://doaj.org/article/6df180a2332146bc930a618f952a3805
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Schematic illustration of MEKi-induced MAPK pathway feedback activation, SHP099 dose-dependent reduction of p-MEK induction by MEKi, and MEKi-induced p-AKT levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab33e010e3ab7eccd5822273f9c9b791
https://doi.org/10.1158/1535-7163.22506412
https://doi.org/10.1158/1535-7163.22506412
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Evaluation of the in vitro synergy in anti-proliferation and the MAPK pathway suppression of MEK and SHP2, PI3K, or RTK inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660e4d6468aaa320a2141ef18295a229
https://doi.org/10.1158/1535-7163.22506403
https://doi.org/10.1158/1535-7163.22506403
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
PDF file 146K, This file contains the legends to Supplementary Figures 1-7 and Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c077e9ee3f485c8ade53fb1b04705
https://doi.org/10.1158/2159-8290.22529976.v1
https://doi.org/10.1158/2159-8290.22529976.v1
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
S1 XLSX file 63K, This Supplementary Table contains the results of ORF screen to identify genes that can rescue the suppression of TBK1 in a KRAS-dependent cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209d5b3de765d71370d93b113a465be1
https://doi.org/10.1158/2159-8290.22529973
https://doi.org/10.1158/2159-8290.22529973
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
FGFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with the MEK inhibitor trametinib in several KRAS-mutant lung and pancreatic cancer cell lines. We hypothesize that other receptor tyrosine kinases (RT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb37e86fd9fce1d8e8b84e82f0895deb
https://doi.org/10.1158/1535-7163.c.6538387.v1
https://doi.org/10.1158/1535-7163.c.6538387.v1
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
mRNA levels (TPM, transcripts per million reads in RNAseq) of SHP2, RTKs, and their ligands in all cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb76ba04ff665a541405d5ba87ccb38
https://doi.org/10.1158/1535-7163.22506388
https://doi.org/10.1158/1535-7163.22506388
Autor:
David A. Barbie, William C. Hahn, Kwok-Kin Wong, Ryan B. Corcoran, Jeffrey A. Engelman, Michael J. Eck, Suzanne Gaudet, Nir Hacohen, Shuji Ogino, William E. Gillanders, Jill P. Mesirov, Lior Rozhansky, Mary T. Labowsky, Whitney Silkworth, Edmond M. Chan, Karolina Maciag, Asher N. Page, Zhi Rong Qian, Jason T. Godfrey, Pablo Tamayo, Jacob B. Reibel, Tran C. Thai, Anna C. Schinzel, Rhine R. Shen, Susan E. Moody, Shenghong Yang, Yu Imamura, Thanh U. Barbie, Travis J. Cohoon, Amir R. Aref, Zehua Zhu
PDF file 1227K, This file contains Supplemental Figures 1-7, which provide additional supporting information for each of the main figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5893bfbe1091c688be62ffa4ec13995c
https://doi.org/10.1158/2159-8290.22529979
https://doi.org/10.1158/2159-8290.22529979
Autor:
Huai-Xiang Hao, Morvarid Mohseni, Giordano Caponigro, Peter S. Hammerman, Jeffrey A. Engelman, Susan E. Moody, Saskia M. Brachmann, Eusebio Manchado, Eric Billy, Anne Haberkorn, Malika Kazic-Legueux, Lukas Manuel Dunkl, Hongyun Wang, Roberto Velazquez, Chen Liu, Hengyu Lu
Quantification of p-MEK and tubulin levels and percentages of p-MEK reduction in the MEKi combination group normalized to tubulin in all cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a55407540f6d444bd5511f15ded794b
https://doi.org/10.1158/1535-7163.22506391.v1
https://doi.org/10.1158/1535-7163.22506391.v1