Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Susan E Howlett"'
Publikováno v:
eLife, Vol 11 (2022)
As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal data. We extract damage and repair transition rates from repeated observations of binary heal
Externí odkaz:
https://doaj.org/article/8c89c9fdfb9d42868a6bc19fd8b347a3
Autor:
Taylor Dunn, Susan E Howlett, Sanja Stanojevic, Aaqib Shehzad, Justin Stanley, Kenneth Rockwood
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 1, p e29219 (2022)
BackgroundIndividuals with dementia and mild cognitive impairment (MCI) experience a wide variety of symptoms and challenges that trouble them. To address this heterogeneity, numerous standardized tests are used for diagnosis and prognosis. myGoalNav
Externí odkaz:
https://doaj.org/article/f58d54b578ed4b65b1c42d01e27a9a26
Autor:
Elias Fares, W Glen Pyle, Gibanananda Ray, Robert A Rose, Eileen M Denovan-Wright, Robert P Chen, Susan E Howlett
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74719 (2013)
This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes. Myocytes were isolated from anesthetized C57BL/6 femal
Externí odkaz:
https://doaj.org/article/51e252a0fd244a1da4cff9e28d4f0a44
Autor:
Jenna L Ross, Susan E Howlett
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38425 (2012)
Sex differences in responses to myocardial ischemia have been described, but whether cardiomyocyte function is influenced by sex in the setting of ischemia and reperfusion has not been elucidated. This study compared contractions and intracellular Ca
Externí odkaz:
https://doaj.org/article/b7844868b07d4092a686b56c281d5b09
Publikováno v:
Age and Ageing. 52
The frailty index (FI) quantifies frailty as deficit accumulation. It has been adapted to employ laboratory test data (FI-Lab). Our objective was to systematically review and meta-analyse the FI-Lab’s ability to predict mortality. Secondary objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f99210a93c51b3ed55b1f8bf0d424a
https://doi.org/10.1093/ageing/afac309
https://doi.org/10.1093/ageing/afac309
Autor:
Alice E. Kane, Sooyoun Shin, Aimee A. Wong, Emre Fertan, Natalia S. Faustova, Susan E. Howlett, Richard E. Brown
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Mouse models of Alzheimer’s disease (AD) exhibit marked differences in life expectancy depending on their genotype and sex. The assessment of frailty could provide a measure of healthspan to facilitate comparisons between different AD models. We us
Externí odkaz:
https://doaj.org/article/f82616eb200d425ba07f2ab50475183a
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Aerobic exercise is a promising intervention to attenuate frailty, but preclinical studies have used only male animals. We investigated the impact of voluntary aerobic exercise on frailty, biological age (FRailty Inferred Geriatric Health Timeline [F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26b6543ec22f0abf157c0f735eb45f6
http://europepmc.org/articles/PMC8751786
http://europepmc.org/articles/PMC8751786
Publikováno v:
Nature Aging. 1:651-665
Frailty is a multiply determined, age-related state of increased risk for adverse health outcomes. We review how the degree of frailty conditions the development of late-life diseases and modifies their expression. The risks for frailty range from su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97119ce25ebe75816f2e9cf7e760de12
https://doi.org/10.1038/s43587-021-00099-3
https://doi.org/10.1038/s43587-021-00099-3
Autor:
Christopher B. Little, Sarah N. Hilmer, Gizem Gemikonakli, Harry Wu, Susan E. Howlett, Heather G. Allore, Trang Tran, John Mach
Publikováno v:
The Journals of Gerontology: Series A. 76:2141-2146
Functional independence is an important aspect of successful aging and differs with age and by sex in humans. Physical performance often declines earlier than other age-associated functional impairments. Rodent models are used to study pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5644ab161a234aed9fd4be9873198474
https://doi.org/10.1093/gerona/glab182
https://doi.org/10.1093/gerona/glab182