Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Susan E Howlett"'
Publikováno v:
eLife, Vol 11 (2022)
As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal data. We extract damage and repair transition rates from repeated observations of binary heal
Externí odkaz:
https://doaj.org/article/8c89c9fdfb9d42868a6bc19fd8b347a3
Autor:
Taylor Dunn, Susan E Howlett, Sanja Stanojevic, Aaqib Shehzad, Justin Stanley, Kenneth Rockwood
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 1, p e29219 (2022)
BackgroundIndividuals with dementia and mild cognitive impairment (MCI) experience a wide variety of symptoms and challenges that trouble them. To address this heterogeneity, numerous standardized tests are used for diagnosis and prognosis. myGoalNav
Externí odkaz:
https://doaj.org/article/f58d54b578ed4b65b1c42d01e27a9a26
Autor:
Kulpreet Cheema, Taylor Dunn, Chere Chapman, Kenneth Rockwood, Susan E. Howlett, Gunes Sevinc
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Background Goal attainment scaling (GAS), an established individualized, patient-centred outcome measure, is used to capture the patient’s voice. Although first introduced ~60 years ago, there are few published guidelines for implementing
Externí odkaz:
https://doaj.org/article/408fc627820e4ec8a48a1adfd85a9f66
Autor:
Elias Fares, W Glen Pyle, Gibanananda Ray, Robert A Rose, Eileen M Denovan-Wright, Robert P Chen, Susan E Howlett
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74719 (2013)
This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes. Myocytes were isolated from anesthetized C57BL/6 femal
Externí odkaz:
https://doaj.org/article/51e252a0fd244a1da4cff9e28d4f0a44
Autor:
Jenna L Ross, Susan E Howlett
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38425 (2012)
Sex differences in responses to myocardial ischemia have been described, but whether cardiomyocyte function is influenced by sex in the setting of ischemia and reperfusion has not been elucidated. This study compared contractions and intracellular Ca
Externí odkaz:
https://doaj.org/article/b7844868b07d4092a686b56c281d5b09
Publikováno v:
Biology of Sex Differences, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Background Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). While endogenous estroge
Externí odkaz:
https://doaj.org/article/d8af1febb92e4022826d1b505923e9bb
Publikováno v:
Age and Ageing. 52
The frailty index (FI) quantifies frailty as deficit accumulation. It has been adapted to employ laboratory test data (FI-Lab). Our objective was to systematically review and meta-analyse the FI-Lab’s ability to predict mortality. Secondary objecti
Autor:
Alice E. Kane, Sooyoun Shin, Aimee A. Wong, Emre Fertan, Natalia S. Faustova, Susan E. Howlett, Richard E. Brown
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Mouse models of Alzheimer’s disease (AD) exhibit marked differences in life expectancy depending on their genotype and sex. The assessment of frailty could provide a measure of healthspan to facilitate comparisons between different AD models. We us
Externí odkaz:
https://doaj.org/article/f82616eb200d425ba07f2ab50475183a
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Aerobic exercise is a promising intervention to attenuate frailty, but preclinical studies have used only male animals. We investigated the impact of voluntary aerobic exercise on frailty, biological age (FRailty Inferred Geriatric Health Timeline [F