Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Susan E, Howlett"'
Autor:
Elise S. Bisset, Susan E. Howlett
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100087- (2024)
Externí odkaz:
https://doaj.org/article/674a22b421344f589b4678a4734c1f13
Autor:
Kulpreet Cheema, Taylor Dunn, Chere Chapman, Kenneth Rockwood, Susan E. Howlett, Gunes Sevinc
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Background Goal attainment scaling (GAS), an established individualized, patient-centred outcome measure, is used to capture the patient’s voice. Although first introduced ~60 years ago, there are few published guidelines for implementing
Externí odkaz:
https://doaj.org/article/408fc627820e4ec8a48a1adfd85a9f66
Autor:
Trang Tran, John Mach, Gizem Gemikonakli, Harry Wu, Heather Allore, Susan E. Howlett, Christopher B. Little, Sarah N. Hilmer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Aging, polypharmacy (concurrent use of ≥ 5 medications), and functional impairment are global healthcare challenges. However, knowledge of the age/sex-specific effects of polypharmacy is limited, particularly on daily physical activities.
Externí odkaz:
https://doaj.org/article/eb4d67e424fa4c2a8773687174f2e38a
Publikováno v:
eLife, Vol 11 (2022)
As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal data. We extract damage and repair transition rates from repeated observations of binary heal
Externí odkaz:
https://doaj.org/article/8c89c9fdfb9d42868a6bc19fd8b347a3
Autor:
Kari Knox, Justin Stanley, James A. Hendrix, Hampus Hillerstrom, Taylor Dunn, Jillian Achenbach, Brian A. Chicoine, Florence Lai, Ira Lott, Sanja Stanojevic, Susan E. Howlett, Kenneth Rockwood
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background As life expectancy of people with Down syndrome (DS) increases, so does the risk of Alzheimer’s disease (AD). Identifying symptoms and tracking disease progression is especially challenging whenever levels of function vary befor
Externí odkaz:
https://doaj.org/article/a64e8a0910b64b74b56d860f0cb9fe95
Autor:
Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The discovery of interventions that slow aging could be accelerated by employing non-invasive biometrics that predict biological age or life expectancy. Here the authors use longitudinal frailty data from naturally aging mice to develop two such tool
Externí odkaz:
https://doaj.org/article/3a49ccbd63f44865818e20ab50fb5065
Autor:
Taylor Dunn, Susan E Howlett, Sanja Stanojevic, Aaqib Shehzad, Justin Stanley, Kenneth Rockwood
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 1, p e29219 (2022)
BackgroundIndividuals with dementia and mild cognitive impairment (MCI) experience a wide variety of symptoms and challenges that trouble them. To address this heterogeneity, numerous standardized tests are used for diagnosis and prognosis. myGoalNav
Externí odkaz:
https://doaj.org/article/f58d54b578ed4b65b1c42d01e27a9a26
Publikováno v:
Biology of Sex Differences, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Background Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). While endogenous estroge
Externí odkaz:
https://doaj.org/article/d8af1febb92e4022826d1b505923e9bb
Autor:
Elise S. Bisset, Susan E. Howlett
Publikováno v:
Aging Medicine, Vol 2, Iss 1, Pp 27-34 (2019)
Abstract Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to explain the heterogeneity in rates of aging in people of the same age. Frailty has important clinical implications, because even minor stressors can
Externí odkaz:
https://doaj.org/article/f6e5bd7d2b494a0f854978c1841ed67c
Publikováno v:
Aging Medicine, Vol 2, Iss 1, Pp 11-17 (2019)
Abstract Objective Early frailty may be captured by a frailty index (FI) based entirely on vital signs and laboratory tests. Our aim was to examine associations between a laboratory‐based FI (FI‐Lab) and adverse health outcomes, and investigate h
Externí odkaz:
https://doaj.org/article/e2294eb6bfbb4dd395eca79aa300a399