Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Susan E, Brockerhoff"'
Autor:
Rachel A. Hutto, Kaitlyn M. Rutter, Michelle M. Giarmarco, Edward D. Parker, Zachary S. Chambers, Susan E. Brockerhoff
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112115- (2023)
Summary: Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy broadly used to improve cellular health and viability. Here
Externí odkaz:
https://doaj.org/article/30668891382845a091b0c21e98133d88
Autor:
Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract Rods and cones use intracellular Ca2+ to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca2+ entry into mitochondria in e
Externí odkaz:
https://doaj.org/article/19fb921ccc8343ada232a66140021e5f
Autor:
Luke F. Enthoven, Yuanyuan Shi, Emily E. Fay, Sue Moreni, Jennie Mao, Emma M. Honeyman, Chase K. Smith, Dale Whittington, Susan E. Brockerhoff, Nina Isoherranen, Rheem A. Totah, Mary F. Hebert
Publikováno v:
Metabolites, Vol 13, Iss 2, p 242 (2023)
Limited data are available on the effects of pregnancy on the maternal metabolome. Therefore, the objective of this study was to use metabolomics analysis to determine pathways impacted by pregnancy followed by targeted confirmatory analysis to provi
Externí odkaz:
https://doaj.org/article/4f35659ab87f442388c0b686a715114c
Autor:
Mark A Kanow, Michelle M Giarmarco, Connor SR Jankowski, Kristine Tsantilas, Abbi L Engel, Jianhai Du, Jonathan D Linton, Christopher C Farnsworth, Stephanie R Sloat, Austin Rountree, Ian R Sweet, Ken J Lindsay, Edward D Parker, Susan E Brockerhoff, Martin Sadilek, Jennifer R Chao, James B Hurley
Publikováno v:
eLife, Vol 6 (2017)
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors su
Externí odkaz:
https://doaj.org/article/aff27e94dd9b414d9153404c6b6c9551
Autor:
James B. Hurley, William Ge, Brian M. Robbings, Kaitlyn M Rutter, Kristine Tsantilas, Susan E. Brockerhoff, Whitney M. Cleghorn, Kellie C Kuch, Edward D Parker, Daniel C Brock, Michelle M. Giarmarco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mitochondria are organelles that make cellular energy. In the retina, mitochondrial health is important for photoreceptor cell function and normal vision. Photoreceptors need more energy at night, but it is unclear how their mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61053d6e2b310544c47ab213051be41d
https://doi.org/10.1073/pnas.2007827117
https://doi.org/10.1073/pnas.2007827117
Autor:
Edward D Parker, Frans Vinberg, William Ge, Whitney M. Cleghorn, James B. Hurley, Rachel Hutto, Susan E. Brockerhoff, Celia M. Bisbach, Benjamin H Bauer, Daniel C Brock, Fatima Abbas
Publikováno v:
Cell Death & Differentiation. 27:1067-1085
Photoreceptors are specialized neurons that rely on Ca2+ to regulate phototransduction and neurotransmission. Photoreceptor dysfunction and degeneration occur when intracellular Ca2+ homeostasis is disrupted. Ca2+ homeostasis is maintained partly by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12bbbb35d9190fdd1120ab7bec0fd95
https://doi.org/10.1038/s41418-019-0398-2
https://doi.org/10.1038/s41418-019-0398-2
Autor:
Ashley A George, Sara Hayden, Lars C Holzhausen, Eva Y Ma, Sachihiro C Suzuki, Susan E Brockerhoff
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84394 (2014)
Highly polarized cells such as photoreceptors require precise and efficient strategies for establishing and maintaining the proper subcellular distribution of proteins. The signals and molecular machinery that regulate trafficking and sorting of syna
Externí odkaz:
https://doaj.org/article/23b32bad8b6647ec833c44fa0724b42b
Autor:
James B. Hurley, Celia M. Bisbach, Frans Vinberg, Fatima Abbas, Deepak Poria, Rachel Hutto, Whitney M. Cleghorn, Susan E. Brockerhoff, Vladimir J. Kefalov
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
Rods and cones use intracellular Ca2+ to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca2+ entry into mitochondria in eukaryotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783d27c7f5bdefa710824c919a8abcb1
https://doi.org/10.1038/s41598-020-72708-x
https://doi.org/10.1038/s41598-020-72708-x
Autor:
Susan E. Brockerhoff, Kaitlyn M Rutter, Daniel C Brock, Whitney M. Cleghorn, Michelle M. Giarmarco, Brian M. Robbings, William Ge, Kristine Tsantilas, Kellie C Kuch, Edward D Parker
Cone photoreceptors in the retina are exposed to intense daylight, and have higher energy demands in darkness. Cones produce energy using a large cluster of mitochondria. Mitochondria are susceptible to oxidative damage, and healthy mitochondrial pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ba794f14d1f3d19e777cc6236d4b26
https://doi.org/10.1101/2020.04.10.030262
https://doi.org/10.1101/2020.04.10.030262
Autor:
Susan E. Brockerhoff, Gabriel H. Travis, Joanna J. Kaylor, Eoghan M. McGarrigle, Diego Cobice, Dionissia A. Pepe, Breandán N. Kennedy, James B. Hurley, Rebecca Ward
Cone photoreceptors in the retina enable vision over a wide range of light intensities. However, the processes enabling cone vision in bright light (i.e. photopic vision) are not adequately understood. Chromophore regeneration of cone photopigments m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4790b98fc8ab067a4411bd208d97a57e
https://doi.org/10.1101/2020.02.15.950915
https://doi.org/10.1101/2020.02.15.950915