Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma

Autor: Jeppe Sejerø Holm, Samuel A. Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L. Reading, Colleen Maher, Ashley Regazzi, Phillip Wong, Hikmat Al-Ahmadie, Gopa Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Morten Nielsen, Jonathan E. Rosenberg, Dean F. Bajorin, Sine Reker Hadrup

Publikováno v: Holm, J S, Funt, S A, Borch, A, Munk, K K, Bjerregaard, A-M, Reading, J L, Maher, C, Regazzi, A, Wong, P, Al-Ahmadie, H, Iyer, G, Tamhane, T, Bentzen, A K, Herschend, N O, De Wolf, S, Snyder, A, Merghoub, T, Wolchok, J D, Nielsen, M, Rosenberg, J E, Bajorin, D F & Hadrup, S R 2022, ' Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma ', Nature Communications, vol. 13, 1935 . https://doi.org/10.1038/s41467-022-29342-0

CD8+ T cell reactivity towards tumor mutation-derived neoantigens is widely believed to facilitate the antitumor immunity induced by immune checkpoint blockade (ICB). Here we show that broadening in the number of neoantigen-reactive CD8+ T cell (NART

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https://pubmed.ncbi.nlm.nih.gov/35410325