Výsledky vyhledávání - "Susan D. Wiedner"

Akademický článek

Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice.

Autor: Natalie C Sadler, Thomas E Angel, Michael P Lewis, Leeanna M Pederson, Lacie M Chauvigné-Hines, Susan D Wiedner, Erika M Zink, Richard D Smith, Aaron T Wright

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47996 (2012)

High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether mitochondrial dysfunction is a direct effect of a

Externí odkaz: https://doaj.org/article/c06d9f4157e64aedb65e641b732f8928

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Disparate Proteome Responses of Pathogenic and Nonpathogenic Aspergilli to Human Serum Measured by Activity-Based Protein Profiling (ABPP)

Autor: Charles Ansong, Suereta Fortuin, Richard D. Smith, Anil K. Shukla, LeeAnna M. Pederson, Beth A. Hofstad, Susan D. Wiedner, Ellen A. Panisko, Aaron T. Wright, Bobbie-Jo M. Webb-Robertson

Publikováno v: Molecular & Cellular Proteomics. 12:1791-1805

Aspergillus fumigatus is the primary pathogen causing the devastating pulmonary disease Invasive Aspergillosis in immunocompromised individuals. There is high genomic synteny between A. fumigatus and closely related rarely pathogenic Neosartorya fisc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0bf87014a6c23a7d29a0fb353e3a91
https://doi.org/10.1074/mcp.m112.026534

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Reactivity of Aziridinomitosene Derivatives Related to FK317 in the Presence of Protic Nucleophiles

Autor: Susan D. Wiedner, Edwin Vedejs

Publikováno v: The Journal of Organic Chemistry. 77:1045-1055

The syntheses and reactivity of N-TBDPS and N-trityl protected derivatives of an aziridinomitosene corresponding to FK317 are described. New reactivity patterns were observed for these highly sensitive and functionally dense heterocycles under mild n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf8360baaf2f376e2edb2e055d97f61
https://doi.org/10.1021/jo202286a

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Formation of dehydroalanine from mimosine and cysteine: artifacts in gas chromatography/mass spectrometry based metabolomics

Autor: Qibin Zhang, Zeping Hu, Richard D. Smith, William F. Morgan, Thomas O. Metz, Susan D. Wiedner, Jong-Seo Kim, Young-Mo Kim

Publikováno v: Rapid Communications in Mass Spectrometry. 25:2561-2564

Gas chromatography-mass spectrometry (GC-MS)-based global metabolomics requires complete chemical derivatization and matching of experimental spectra with those in various commercial or freely available databases in a high throughput manner.[1–6] A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::772d9f87e77464a0f231054b109888b6
https://doi.org/10.1002/rcm.5134

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Multiplexed activity-based protein profiling of the human pathogen Aspergillus fumigatus reveals large functional changes upon exposure to human serum

Autor: Anil K. Shukla, Susan D. Wiedner, Aaron T. Wright, Kristin E. Burnum, Ellen A. Panisko, Charles Ansong, Lacie M. Chauvigné-Hines, Richard D. Smith, Suereta Fortuin, Lindsey N. Anderson, LeeAnna M. Pederson

Publikováno v: The Journal of biological chemistry. 287(40)

Environmental adaptability is critical for survival of the fungal human pathogen Aspergillus fumigatus in the immunocompromised host lung. We hypothesized that exposure of the fungal pathogen to human serum would lead to significant alterations to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24882f1ac93cac0aa4cb700767d18a9a
https://pubmed.ncbi.nlm.nih.gov/22865858

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Aziridinomitosanes via lactam cyclization

Autor: Edwin Vedejs, Susan D. Wiedner

Publikováno v: Organic letters. 12(18)

Aziridinomitosane ketones 4 and 24 are accessed by internal acyl anion equivalent-lactam cyclization of 29 in a convergent route. The key aziridinolactam 6 is prepared by tin−lithium exchange via the lithiated aziridine 11.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a26e2c8d0bc56325977186a3236c4cc
https://pubmed.ncbi.nlm.nih.gov/20738104

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