Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Susan D. Reynolds"'
Publikováno v:
European Respiratory Review, Vol 33, Iss 173 (2024)
Pulmonary mucociliary clearance (MCC) is an important defence mechanism of the respiratory system and clears pathogens and foreign particles from the airways. Understanding the effect of disease states, drugs, toxins and airway manipulations on MCC c
Externí odkaz:
https://doaj.org/article/6c714dd18c4845e0a755e8c11dff084b
Autor:
Zheng Hong Tan, Sayali Dharmadhikari, Lumei Liu, Jane Yu, Kimberly M. Shontz, Jacob T. Stack, Christopher K. Breuer, Susan D. Reynolds, Tendy Chiang
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Extensive tracheal injury or disease can be life-threatening but there is currently no standard of care. Regenerative medicine offers a potential solution to long-segment tracheal defects through the creation of scaffolds that support the ge
Externí odkaz:
https://doaj.org/article/c0db940d1af44a219fa5135946c3d2e3
Autor:
Zheng Hong Tan, Lumei Liu, Sayali Dharmadhikari, Kimberly M. Shontz, Lily Kreber, Sarah Sperber, Jane Yu, Woo Yul Byun, Sarah C. Nyirjesy, Amy Manning, Susan D. Reynolds, Tendy Chiang
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract There is currently no suitable autologous tissue to bridge large tracheal defects. As a result, no standard of care exists for long‐segment tracheal reconstruction. Tissue engineering has the potential to create a scaffold from allografts
Externí odkaz:
https://doaj.org/article/bcdddcce2bf248b9b183f8fcd96b38e4
Autor:
Natalie A. Kelly, Kimberly M. Shontz, Maxwell Bergman, Amy M. Manning, Susan D. Reynolds, Tendy Chiang
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 6, Pp 2119-2125 (2022)
Abstract Objective While airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have or are suspected of having an a
Externí odkaz:
https://doaj.org/article/5a57212022564004a284554bf0e5aa41
Autor:
Moumita Ghosh, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Don Hayes Jr., Saranga Wijeratne, Zhang Hong Tan, Tendy Chiang, John E. Mahoney, Gianni Carraro, Barry R. Stripp, Susan D. Reynolds
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1696-1713 (2021)
Abstract Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue‐specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demons
Externí odkaz:
https://doaj.org/article/9d6a17e6e3c24ef9bf31f1af6b2661cd
Autor:
Susan D. Reynolds, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Saranga Wijeratne, Zheng Hong Tan, Tendy Chiang, Estelle Cormet-Boyaka
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Mucosecretory lung disease compromises airway epithelial function and is characterized by goblet cell hyperplasia and ciliated cell hypoplasia. Goblet and ciliated cell types are derived from tracheobronchial stem/progenitor cells via a Notch-depende
Externí odkaz:
https://doaj.org/article/6f3901496ceb49e7a15478a5f706a8b8
Autor:
Meisam Naeimi Kararoudi, Alfahdah Alsudayri, Cynthia L. Hill, Ezgi Elmas, Yasemin Sezgin, Aarohi Thakkar, Mark E. Hester, Daniel T. Malleske, Dean A. Lee, Matthew L. Neal, Mark R. Perry, Jill A. Harvilchuck, Susan D. Reynolds
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Respiratory system damage is the primary cause of mortality in individuals who are exposed to vesicating agents including sulfur mustard (SM). Despite these devastating health complications, there are no fielded therapeutics that are specific for suc
Externí odkaz:
https://doaj.org/article/6111819b0f364180ad5dd6f223c4f700
Autor:
Cynthia M. Schwartz, Jacob Stack, Cynthia L. Hill, Scott W. Lallier, Tendy Chiang, Jed Johnson, Susan D. Reynolds
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 4, Iss 4, Pp 446-454 (2019)
Objective Significant morbidity and mortality are associated with clinical use of synthetic tissue‐engineered tracheal grafts (TETG). Our previous work focused on an electrospun polyethylene terephthalate and polyurethane (PET/PU) TETG that was tes
Externí odkaz:
https://doaj.org/article/9b077e0359e748718b86604c25884359
Autor:
Lumei Liu, Sayali Dharmadhikari, Robert A. Pouliot, Michael M. Li, Peter M. Minneci, Zhenghong Tan, Kimberly Shontz, Jed Johnson, Susan D. Reynolds, Christopher K. Breuer, Daniel J. Weiss, Tendy Chiang
Publikováno v:
Bioengineering, Vol 8, Iss 8, p 116 (2021)
Synthetic scaffolds for the repair of long-segment tracheal defects are hindered by insufficient biocompatibility and poor graft epithelialization. In this study, we determined if extracellular matrix (ECM) coatings improved the biocompatibility and
Externí odkaz:
https://doaj.org/article/eb93d533b79e4011a9d32ee721dd0c94
Autor:
Karin A. Zemski Berry, Bilan Li, Susan D. Reynolds, Robert M. Barkley, Miguel A. Gijón, Joseph A. Hankin, Peter M. Henson, Robert C. Murphy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1551-1560 (2011)
Lipid mediators are important in lung biochemistry and are derived from the enzymatic oxidation of arachidonic and docosahexaenoic acids, which are PUFAs that are present in phospholipids in cell membranes. In this study, MALDI imaging MS was used to
Externí odkaz:
https://doaj.org/article/6314e5e4164248c6be0cfeab847bacda