Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susan D. Craddock"'
Autor:
Susan D. Craddock, Tiffanie Clinkinbeard, Rodney P. Guttmann, Sarbani Ghoshal, L. Creed Pettigrew
Publikováno v:
Brain Research. 1499:129-135
Ischemic stroke results in multiple injurious signals within a cell including dysregulation of calcium homeostasis. Consequently, there is an increase in the enzymatic activity of the calpains, calcium dependent proteases that are thought to contribu
Autor:
Susan D. Craddock, Russell E. Rydel, Virginia L. Smith-Swintosky, L. Creed Pettigrew, Mark P. Mattson, Alan R. Culwell
Publikováno v:
Journal of Neurochemistry. 63:781-784
The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide seque
Autor:
Mary L. Holtz, L C Pettigrew, Susan D. Craddock, Stephen L. Minger, Sidney W. Whiteheart, James W. Geddes, Robert Siman
Publikováno v:
Brain Research. 810:181-199
Excitatory amino acids may promote microtubular proteolysis observed in ischemic neuronal degeneration by calcium-mediated activation of calpain, a neutral protease. We tested this hypothesis in an animal model of focal cerebral ischemia without repe
Autor:
Mark P. Mattson, Virginia L. Smith-Swintosky, Robert M. Sapolsky, Sheila M. Brooke, Chris Phares, L. Creed Pettigrew, Susan D. Craddock
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 16:585-598
Increasing evidence indicates that glucocorticoids (GCs), produced in response to physical/emotional stressors, can exacerbate brain damage resulting from cerebral ischemia and severe seizure activity. However, much of the supporting evidence has com
Autor:
Hsin-Hsiung Tai, Susan D. Craddock, L. Creed Pettigrew, Steven M. Butler, Robert A. Yokel, Jerome J. Meyer
Publikováno v:
Brain Research. 691:243-247
We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 14:554-564
Previous studies in gerbils have shown that cytoskeletal disruption and a loss of the dendritic microtubule-associated protein, MAP2, may occur after short periods of transient global ischemia. τ, a predominantly axonal microtubule-associated protei
Autor:
L. Creed Pettigrew, William F. Maragos, Chava B. Pocernich, Amit S. Korde, Peter C. Waldmeier, Susan D. Craddock
Publikováno v:
Journal of neurotrauma. 24(5)
Cerebral ischemia followed by reperfusion activates numerous pathways that lead to cell death. One such pathway involves the release of large quantities of the excitatory amino acid glutamate into the synapse and activation of N-methyl-D-aspartate re
Publikováno v:
Journal of neurochemistry. 94(6)
Ischemic stroke is caused by acute neuronal degeneration provoked by interruption of cerebral blood flow. Although the mechanisms contributing to ischemic neuronal degeneration are myriad, mitochondrial dysfunction is now recognized as a pivotal even
Publikováno v:
Brain research. 898(1)
Objective: To determine whether neuronal and inducible nitric oxide synthase (nNOS and iNOS) isoforms are expressed within cortical neurons during early reperfusion after focal cerebral ischemia. Methods: Male spontaneously hypertensive rats underwen
Autor:
Mary L. Holtz, Stephen L. Minger, L. Creed Pettigrew, Nathan Hall, James W. Geddes, Susan D. Craddock
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 16(6)
Calpain, a neutral protease activated by calcium, may promote microtubular proteolysis in ischemic brain. We tested this hypothesis in an animal model of focal cerebral ischemia without reperfusion. The earliest sign of tissue injury was observed aft