Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susan D Mertins"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Pharmacodynamic (PD) models are mathematical models of cellular reaction networks that include drug mechanisms of action. These models are useful for studying predictive therapeutic outcomes of novel drug therapies in silico. However, PD mod
Externí odkaz:
https://doaj.org/article/99dd03527400422590623ce16fe53775
Autor:
Michael L. Blinov, Susan D. Mertins
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/e048b70205eb4dc3b1f75bf09f5a68c5
Autor:
Susan D Mertins, Dominic A Scudiero, Melinda G Hollingshead, Raymond D Divelbiss, Michael C Alley, Anne Monks, David G Covell, Karen M Hite, David S Salomon, John E Niederhuber
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57099 (2013)
BACKGROUND: Cancer stem cells (CSC) are thought to be responsible for tumor maintenance and heterogeneity. Bona fide CSC purified from tumor biopsies are limited in supply and this hampers study of CSC biology. Furthermore, purified stem-like CSC sub
Externí odkaz:
https://doaj.org/article/36d4ba16194044c6a39e47c1292af060
Autor:
Susan D. Mertins
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Computational dynamic ODE models of cell function describing biochemical reactions have been created for decades, but on a small scale. Still, they have been highly effective in describing and predicting behaviors. For example, oscillatory phospho-ER
Externí odkaz:
https://doaj.org/article/316b803cc2af48abaf7ca3cf240aae09
Autor:
Susan D. Mertins, Natalie M. Isenberg, Kristofer-Roy Reyes, Byung-Jun Yoon, Nathan Urban, Manasi P. Jogalekar, Morgan E. Diolaiti, M. Ryan Weil, Eric A. Stahlberg
Pharmacodynamic models provide inroads to understanding key mechanisms of action and may significantly improve patient outcomes in cancer with improved ability to determine therapeutic benefit. Additionally, these models may also lead to insights int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67dd540737e687148820e57e811dca38
https://doi.org/10.1101/2023.02.08.527527
https://doi.org/10.1101/2023.02.08.527527
Autor:
Andrea Abati, Robert Worrell, Joanna Regis, Erick Gamelin, Susan D. Mertins, Lyn A. Mickley, Susan E. Bates, W. Marston Linehan
Publikováno v:
Journal of Urology. 162:217-224
Much remains to be learned about drug resistance in the biology of RCC and its metastases. We measured MDR-1/P-glycoprotein expression in 19 tumor samples from patients with metastatic RCC by RNase protection and quantitative PCR assays. The median l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6aee3292e1fbe62f84b00d8776e16b
https://doi.org/10.1097/00005392-199907000-00071
https://doi.org/10.1097/00005392-199907000-00071
Autor:
Susan D. Mertins, Emmanuel Roilides, Carol A. Lyman, Philip A. Pizzo, Stephen J. Chanock, Thomas J. Walsh, David Venzon, David J. Cole
Publikováno v:
Cytokine. 8:42-48
The ex vivo effects of macrophage colony-stimulating factor (M-CSF) on antifungal and antibacterial activities of human elutriated monocytes were studied. Cells were isolated prior to the initiation of therapy, on day 3 and at week 7, in six patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627ff67a8a1c32fae079fe32e192c13a
https://doi.org/10.1006/cyto.1996.0006
https://doi.org/10.1006/cyto.1996.0006
Autor:
Susan D. Mertins, John E. Niederhuber, Meghan Gowens, Dominic A. Scudiero, Christina H. Stuelten, Karen M. Hite, Robert H. Shoemaker, Melinda G. Hollingshead, Mike Alley, Johanna I. Busch, Mark W. Burkett
Publikováno v:
Stem Cells
Tumor stem cells or cancer initiating cells (CICs) are single tumor cells that can regenerate a tumor or a metastasis. The identification and isolation of CICs remain challenging, and a variety of putative CIC markers have been described. We hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64f408b26e325dcde8f64462da65a43
https://pubmed.ncbi.nlm.nih.gov/20178109
https://pubmed.ncbi.nlm.nih.gov/20178109
Autor:
Susan D, Mertins, Timothy G, Myers, Susan L, Holbeck, Wilma, Medina-Perez, Elaine, Wang, Glenda, Kohlhagen, Yves, Pommier, Susan E, Bates
Publikováno v:
Molecular cancer therapeutics. 3(7)
We identified five structurally related dimethane sulfonates with putative selective cytotoxicity in renal cancer cell lines. These compounds have a hydrophobic moiety linked to a predicted alkylating group. A COMPARE analysis with the National Cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9718f43a9f32437e7d14f3afa779847a
https://pubmed.ncbi.nlm.nih.gov/15252146
https://pubmed.ncbi.nlm.nih.gov/15252146
Autor:
Thomas R. Silvers, Anne Monks, David H. Evans, Eric C. Polley, Russell Reinhart, Annamaria Rapisarda, Chad Ogle, Rene Delosh, Gurmeet Kaur, Beverly A. Teicher, John Connelly, Susan D. Mertins, Joel Morris, Julie Laudeman
Publikováno v:
Journal of Clinical Oncology. 32:e22067-e22067
e22067 Background: Sarcomas are rare heterogeneous cancers with significant unmet medical need. Identification of gene expression associated with response to potential novel clinical agents is important. Methods: Response of 62 adult and pediatric hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0f8c6152b278e95025d02f1c6bac53
https://doi.org/10.1200/jco.2014.32.15_suppl.e22067
https://doi.org/10.1200/jco.2014.32.15_suppl.e22067