BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle

Autor: Elizabeth Glass, John L. Williams, Susan Craigmile, Alison J. Douglas, Chris Haley, R. Baxter

Publikováno v: Vaccine. 28:28-37

This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8978e423f57f1accc69571f3acd03359
https://doi.org/10.1016/j.vaccine.2009.09.131

Quantitative analysis of pro-inflammatory cytokine mRNA expression in Theileria annulata-infected cell lines derived from resistant and susceptible cattle

Autor: Elizabeth Glass, Susan Craigmile, Anthea Springbett, D.V. Malhotra, George C. Russell, A. K. Nichani, Kirsty McGuire, Anju Manuja

Publikováno v: Veterinary Immunology and Immunopathology. 99:87-98

The pathogenic mechanisms involved in tropical theileriosis, caused by the tick-borne protozoan parasite Theileria annulata, are unclear. Pathology is associated with the schizont stage of the parasite, which resides within bovine macrophages. Breed-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53c6e9dc76ec6e1b85822198fbb110b
https://doi.org/10.1016/j.vetimm.2004.01.003

Characterization of efferent lymph cells and their function following immunization of cattle with an allogenic Theileria annulata infected cell line

Autor: Simon P. Graham, C.G.D. Brown, J.D.M. Campbell, A. K. Nichani, Elizabeth Glass, Roger L. Spooner, Susan Craigmile

Publikováno v: Veterinary Immunology and Immunopathology. 93:39-49

Immunization of cattle with in vitro propagated bovine mononuclear cells infected with Theileria annulata induces a protective immune response. Activation and effector function of T cells exiting the lymph node draining the site of cell line immuniza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce24ffa62cf114fdfe72b1d827f5ab2d
https://doi.org/10.1016/s0165-2427(03)00045-x

Diminished IL-2 responses and alteration of CD2 expression on CD8+ T cells are associated with a lack of cytotoxic T cell responses during Theileria annulata infection

Autor: J.D.M. Campbell, A. K. Nichani, Susan Craigmile, Roger L. Spooner

Publikováno v: Clinical and Experimental Immunology. 116:316-321

SUMMARY Theileria annulata is a tick-borne protozoan parasite which causes the disease bovine tropical theileriosis. In immunized or drug-treated animals, the pathogenic macroschizont stage of the parasite is destroyed by MHC class I-restricted cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd5c4b83b3072f5dcd4767e89d0dfcd
https://doi.org/10.1046/j.1365-2249.1999.00895.x

Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide

Autor: John L. Williams, Susan Craigmile, Sara Knott, Elizabeth Glass, Richard J. Leach

Publikováno v: BMC Genetics, Vol 11, Iss 1, p 107 (2010)
BMC Genetics
Leach, R J, Craigmile, S, Knott, S A, Williams, J L & Glass, E J 2010, ' Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide ', BMC Genetics, vol. 11, 107, pp. 11 . https://doi.org/10.1186/1471-2156-11-107

Background Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65de1b140c5858201616b96d1fe13b84
http://www.biomedcentral.com/1471-2156/11/107