Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Susan Cohrs"'
Autor:
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential changes in ACE2 expressi
Externí odkaz:
https://doaj.org/article/ad4f974295474f0392325fbd07ff6ab8
Autor:
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne
Publikováno v:
Cancer Medicine, Vol 11, Iss 20, Pp 3820-3836 (2022)
Abstract Backgorund Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and resp
Externí odkaz:
https://doaj.org/article/1f5177ae512441ffab056e955c214925
Autor:
Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli, Jürgen Grünberg
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also shown radiosensitizi
Externí odkaz:
https://doaj.org/article/da8f452beecc49f394a1e88ce66710da
Autor:
Janine Schniering, Martina Benešová, Matthias Brunner, Stephanie Haller, Susan Cohrs, Thomas Frauenfelder, Bart Vrugt, Carol Feghali-Bostwick, Roger Schibli, Oliver Distler, Cristina Müller, Britta Maurer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Interstitial lung disease (ILD) is a common and severe complication in rheumatic diseases. Folate receptor-β is expressed on activated, but not resting macrophages which play a key role in dysregulated tissue repair including ILD. We the
Externí odkaz:
https://doaj.org/article/9cf613af00f84c349975081b232bb7de
Autor:
Francesca Borgna, Patrick Barritt, Pascal V. Grundler, Zeynep Talip, Susan Cohrs, Jan Rijn Zeevaart, Ulli Köster, Roger Schibli, Nicholas P. van der Meulen, Cristina Müller
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 536 (2021)
The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes. The aim of this study was to use dual-isotope SPECT imaging in order to demons
Externí odkaz:
https://doaj.org/article/5d0e012b9f744ee4ad5cef2e055a967c
Autor:
Cristina Müller, Patrycja Guzik, Klaudia Siwowska, Susan Cohrs, Raffaella M. Schmid, Roger Schibli
Publikováno v:
Molecules, Vol 23, Iss 6, p 1465 (2018)
Folic-acid-based radioconjugates have been developed for nuclear imaging of folate receptor (FR)-positive tumors; however, high renal uptake was unfavorable in view of a therapeutic application. Previously, it was shown that pre-injection of pemetrex
Externí odkaz:
https://doaj.org/article/40ac09529df748eea1fce3996a0e14e8
Publikováno v:
Pharmaceuticals, Vol 10, Iss 3, p 72 (2017)
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes. The cervical KB tumor cells have evolved as the standard mo
Externí odkaz:
https://doaj.org/article/18cc818f27e04e20abf6052df61523ef
Autor:
Patrycja Guzik, Luisa M. Deberle, Cristina Müller, Susan Cohrs, Silvan D. Boss, Hsin-Yu Fang, Simon M. Ametamey, Martina Benešová, Roger Schibli
Publikováno v:
J Nucl Med
The aim of this study was to identify a folate receptor-α (FRα)–selective PET agent potentially suitable for the selection of patients who might profit from FRα-targeted therapies. The 6R and 6S isomers of (18)F-aza-5-methyltetrahydrofolate (MTH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8eae56b3d7eba3bb2469a7ac031413
https://doi.org/10.2967/jnumed.120.255760
https://doi.org/10.2967/jnumed.120.255760
Autor:
Patrycja Guzik, Cristina Müller, Susan Cohrs, Klaudia Siwowska, Hsin-Yu Fang, Peter Bernhardt, Roger Schibli
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 48 (4)
European Journal of Nuclear Medicine and Molecular Imaging, 48 (4)
PurposeIt was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370a114cb55f3f4591c01edffcaf5301
https://doi.org/10.1007/s00259-020-05054-9
https://doi.org/10.1007/s00259-020-05054-9
Publikováno v:
Molecular Pharmaceutics. 17:2044-2053
The strategy of using radioligands for targeting the prostate-specific membrane antigen (PSMA) revealed to be promising for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Recently developed albumin-binding PSMA radioligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cbf48c488d57db5c978af283e5c092
https://doi.org/10.1021/acs.molpharmaceut.0c00199
https://doi.org/10.1021/acs.molpharmaceut.0c00199