Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Susan Clardy"'
Autor:
Brian Jones, Pamela Shaw, Naniye Malli Cetinbas, Travis Monnell, Winnie Lee, Kalli Catcott, Chen-Ni Chin, Kelly Slocum, LiuLiang Qin, Kenneth Avocetien, Keith Bentley, Susan Clardy, Eugene Kelleher, Joshua Thomas, Rebecca Mosher, Dorin Toader, Jeremy Duvall, Raghida Bukhalid, Marc Damelin, Timothy Lowinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/b5031bee1db5458fb014131f0b1a8d8c
Autor:
Naniye Malli Cetinbas, Kalli C. Catcott, Travis Monnell, Jahna Soomer-James, Keith Bentley, Susan Clardy, Bingfan Du, Eoin Kelleher, Marina Protopopova, Cheri Stevenson, Joshua D. Thomas, Alex Uttard, Dorin Toader, Jeremy Duvall, Raghida Bukhalid, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:2114-2114
STING pathway agonism has emerged as a potential therapeutic strategy to stimulate anti-tumor immune responses. We have previously shown that tumor cell-targeted antibody-drug conjugates (ADCs) carrying a novel STING agonist induce anti-tumor activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61ff92e4fb7c9e4739a253221532097
https://doi.org/10.1158/1538-7445.am2022-2114
https://doi.org/10.1158/1538-7445.am2022-2114
Autor:
Jeremy R. Duvall, Raghida A. Bukhalid, Naniye M. Cetinbas, Kalli C. Catcott, Kelly Lancaster, Keith W. Bentley, Suzanna Clark, Susan Clardy, Scott D. Collins, Anouk Dirksen, Elizabeth Ditty, Bingfan Du, Eugene W. Kelleher, Travis Monnell, Marina Protopopova, Caitlin Routhier, Cheri Stevenson, Elena Ter-Ovanesyan, Joshua D. Thomas, Alex Uttard, Jason Wang, Phonphimon Wongthida, Ling Xu, Annika Yau, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:3503-3503
We present here a novel therapeutic agent, XMT-2056, that results in robust anti-tumor activity mediated by an immune response through targeted delivery of a STING agonist to the tumor microenvironment. By leveraging an antibody-drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104b7acc0fcee8f20a6655acfc9a034
https://doi.org/10.1158/1538-7445.am2022-3503
https://doi.org/10.1158/1538-7445.am2022-3503
Autor:
Kalli C. Catcott, Susan Clardy, Jack Sadowsky, Rebecca K. Rowntree, Naniye Malli Centibas, Ling Xu, Andy Polson, Kenneth Avocetien, Tyler Carter, Mark Nazzaro, Dokyong \\'DK\\' Kim, Thomas H. Pillow, Neelie Zacharias, Cong Wu, Jeffrey Zurita, Elizabeth Ditty, Stephen Bradley, Alex Uttard, Bingfan Du, William S. Sawyer, Doug Leipold, Gail Lewis Phillips, LiuLiang Qin, Kelly Slocum, Geoffrey Del Rosario, Ginny Li, Shang-Fan Yu, David Lee, Radha Iyengar, Marc Damelin, Dorin Toader, Timothy B. Lowinger
Publikováno v:
Molecular Cancer Therapeutics. 20:P167-P167
Key defining attributes of an antibody-drug conjugate (ADC) include the choice of targeting antibody, linker, and the drug-to-antibody ratio (DAR). The choice of DAR, within the constraints of acceptable physicochemical properties for the given platf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935b7e76f6213d4a5e30f27ebae7723c
https://doi.org/10.1158/1535-7163.targ-21-p167
https://doi.org/10.1158/1535-7163.targ-21-p167
Autor:
Shawn Fessler, Anouk Dirksen, Scott D. Collins, Ling Xu, Winnie Lee, Jason Wang, Ron Eydelloth, Elena Ter-Ovanesyen, Jeffrey Zurita, Elizabeth Ditty, Barrett Nehilla, Susan Clardy, Tyler Carter, Kenneth Avocetien, Mark Nazzaro, Nam Le, Kalli C. Catcott, Alex Uttard, Bingfan Du, Chen-Ni Chin, Rebecca Mosher, Kelly Slocum, Liuliang Qin, David Lee, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 80:2894-2894
The Dolasynthen platform incorporates the highly potent anti-mitotic agent auristatin F-HPA (AF-HPA), with its associated DolaLock mechanism of controlled bystander effect, and enables the synthesis of antibody-drug conjugates (ADCs) with precise con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d13a6293b254a8a5ceb2133d5934aa3
https://doi.org/10.1158/1538-7445.am2020-2894
https://doi.org/10.1158/1538-7445.am2020-2894
Publikováno v:
ChemMedChem. 8:582-586
Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B(12)-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fd7ed43ecf378fb2319024c40365ad
https://doi.org/10.1002/cmdc.201200461
https://doi.org/10.1002/cmdc.201200461
Publikováno v:
Synlett. 23:2363-2366
Reaction of vitamin B12 (B12) with excess 2-iodoxybenzoic acid and 2-hydroxypyridine leads to selective oxidation of the 5′-hydroxyl group of the ribose tail of B12 in a 30% isolated yield. The acid derivative was purified in one step by HPLC chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77140373a8340e79a8aed5d62ec48e0
https://doi.org/10.1055/s-0032-1317160
https://doi.org/10.1055/s-0032-1317160
Publikováno v:
Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films. 14:1137-1141
This article reports the use of an optical emission diagnostic as an in situ monitor of the photoresist etch rate during contact etch in a commercial, hot wall high density plasma reactor. The chamber was conditioned by prior photoresist etch and pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfee3e9607ae26f05e433d89aca92431
https://doi.org/10.1116/1.580283
https://doi.org/10.1116/1.580283
Publikováno v:
ChemMedChem. 8:800-800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c3a95c8e0764b44215f02d0082de28
https://doi.org/10.1002/cmdc.201390014
https://doi.org/10.1002/cmdc.201390014
Publikováno v:
MedChemComm. 3:1054
The practical use of the vitamin B12 uptake pathway to orally deliver peptides and proteins is much debated. To understand the full potential of the pathway however, a deeper understanding of the impact B12 conjugation has on peptides and proteins is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb5e287301d7e9b79fe9df58b0b5cdc
https://doi.org/10.1039/c2md20040f
https://doi.org/10.1039/c2md20040f