Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Susan C. Straley"'
Autor:
Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i
Externí odkaz:
https://doaj.org/article/137463cd821e4008999c8df2193823b3
Autor:
Alan M. Kaplan, Nico van Rooijen, Susan C. Straley, Zhan Ye, Edward J. Kerschen, Donald A. Cohen
Publikováno v:
Ye, Z, Kerschen, E J, Cohen, D, Kaplan, A M, van Rooijen, N & Straley, S C 2009, ' Gr1(+) Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague ', Infection and Immunity, vol. 77, no. 9, pp. 3791-3806 . https://doi.org/10.1128/IAI.00284-09
Infection and Immunity, 77(9), 3791-3806. American Society for Microbiology
Infection and Immunity, 77(9), 3791-3806. American Society for Microbiology
YopM, a protein toxin ofYersinia pestis, is necessary for virulence in a mouse model of systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion from blood and spleen samples of infected mice. However, in this study w
Publikováno v:
Microbiology. 155:2509-2521
Cells of wild-typeYersinia pestisexhibit a low-calcium response (LCR) defined as bacteriostasis with expression of a pCD-encoded type III secretion system (T3SS) during cultivation at 37 °C without added Ca2+versus vegetative growth with downregulat
Autor:
Robert D. Perry, Tanya Myers-Morales, Stanislav Forman, Clarissa Cowan, Christine R. Wulff, Susan C. Straley
Publikováno v:
Infection and Immunity. 76:578-587
In all Yersinia pestis strains examined, the adhesin/invasin yadA gene is a pseudogene, yet Y. pestis is invasive for epithelial cells. To identify potential surface proteins that are structurally and functionally similar to YadA, we searched the Y.
Publikováno v:
Infection and Immunity. 74:6501-6504
We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Δ pgm strains of Yersinia pestis ; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, thes
Publikováno v:
Microbial Pathogenesis. 38:259-266
The signature-tagged mutagenesis (STM) method was applied in a protocol designed to identify genes required for Yersinia pestis invasion into epithelial cells. A library of 3060 mutants of Y. pestis CO99-3015 was made and assayed using an in vitro in
Autor:
Alan M. Kaplan, Li Zeng, Edward J. Kershen, Susan C. Straley, Donald A. Cohen, Jiayou Zhang, Sandra H. Burnett
Publikováno v:
Journal of Leukocyte Biology. 75:612-623
Transgenic mice expressing an inducible suicide gene, which allows systemic and reversible elimination of macrophages, were developed. A macrophage-specific c-fms promoter was used to express enhanced green fluorescent protein and a drug-inducible su
Publikováno v:
Infection and Immunity. 71:937-947
YopM is a leucine-rich repeat (LRR) virulence protein that is delivered into host cells when any of the three human-pathogenic species of Yersinia binds to mammalian cells. It exhibits heterogeneity of size and sequence among the yersiniae, but the f
Publikováno v:
Molecular Microbiology. 43:411-423
LcrQ is a regulatory protein unique to Yersinia. Previous study in Yersinia pseudotuberculosis and Yersinia enterocolitica prompted the model in which LcrQ negatively regulates the expression of a set of virulence proteins called Yops, and its secret
Publikováno v:
Microbial Pathogenesis. 30:193-209
The plague virulence protein YopM of Yersinia pestis KIM5 belongs to the large family of leucine-rich repeat (LRR) proteins. The only activity demonstrated so far for YopM is thrombin-binding, which could be a function of the small amount of YopM tha