Toward a molecular pathogenic pathway for Yersinia pestis YopM

Autor: Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)

YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i

Externí odkaz: https://doaj.org/article/137463cd821e4008999c8df2193823b3

Gr1+Cells Control Growth of YopM-NegativeYersinia pestisduring Systemic Plague

Autor: Alan M. Kaplan, Nico van Rooijen, Susan C. Straley, Zhan Ye, Edward J. Kerschen, Donald A. Cohen

Publikováno v: Ye, Z, Kerschen, E J, Cohen, D, Kaplan, A M, van Rooijen, N & Straley, S C 2009, ' Gr1(+) Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague ', Infection and Immunity, vol. 77, no. 9, pp. 3791-3806 . https://doi.org/10.1128/IAI.00284-09
Infection and Immunity, 77(9), 3791-3806. American Society for Microbiology

YopM, a protein toxin ofYersinia pestis, is necessary for virulence in a mouse model of systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion from blood and spleen samples of infected mice. However, in this study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4dfcb373aee81effe00e81e46502cb
https://doi.org/10.1128/iai.00284-09

yadBC of Yersinia pestis , a New Virulence Determinant for Bubonic Plague

Autor: Robert D. Perry, Tanya Myers-Morales, Stanislav Forman, Clarissa Cowan, Christine R. Wulff, Susan C. Straley

Publikováno v: Infection and Immunity. 76:578-587

In all Yersinia pestis strains examined, the adhesin/invasin yadA gene is a pseudogene, yet Y. pestis is invasive for epithelial cells. To identify potential surface proteins that are structurally and functionally similar to YadA, we searched the Y.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4567acc5adb2ba406b8cec1499a7a8d8
https://doi.org/10.1128/iai.00219-07

Unexpected results from the application of signature-tagged mutagenesis to identify Yersinia pestis genes required for adherence and invasion

Autor: S.A. Leigh, Susan C. Straley, Robert D. Perry, Stanislav Forman

Publikováno v: Microbial Pathogenesis. 38:259-266

The signature-tagged mutagenesis (STM) method was applied in a protocol designed to identify genes required for Yersinia pestis invasion into epithelial cells. A library of 3060 mutants of Y. pestis CO99-3015 was made and assayed using an in vitro in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a40ea1a5c89582ad9fb9235929ed6
https://doi.org/10.1016/j.micpath.2005.02.004

Application of a Saccharomyces cerevisiae Model To Study Requirements for Trafficking of Yersinia pestis YopM in Eucaryotic Cells

Autor: Sidney W. Whiteheart, Elzbieta Skrzypek, Tanya Myers-Morales, Susan C. Straley

Publikováno v: Infection and Immunity. 71:937-947

YopM is a leucine-rich repeat (LRR) virulence protein that is delivered into host cells when any of the three human-pathogenic species of Yersinia binds to mammalian cells. It exhibits heterogeneity of size and sequence among the yersiniae, but the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1609226e9bb8d69bac602f71c924f042
https://doi.org/10.1128/iai.71.2.937-947.2003