Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susan C. Menzies"'
Autor:
Lisa K. Kozicky, Susan C. Menzies, Zheng Yu Zhao, Tariq Vira, Kiera Harnden, Kwestan Safari, Kate L. Del Bel, Stuart E. Turvey, Laura M. Sly
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Intravenous Immunoglobulin (IVIg) is used to treat autoimmune or inflammatory diseases, but its mechanism of action is not completely understood. We asked whether IVIg can induce interleukin-10 (IL-10) and reduce pro-inflammatory cytokine production
Externí odkaz:
https://doaj.org/article/baaeb81bd7814f18bff59788d363384d
Publikováno v:
Mucosal Immunology. 12:1187-1200
Crohn's disease is an immune-mediated disease characterized by inflammation along the gastrointestinal tract. Fibrosis requiring surgery occurs in one-third of people with Crohn's disease but there are no treatments for intestinal fibrosis. Mice defi
Autor:
Susan C. Menzies, Jessica Leung, Mahdis Monajemi, Rym Ben-Othman, Tobias R. Kollmann, Laura M. Sly, Bing Cai, Shera Fisk, Yvonne C. F. Pang, Jacob Rozmus
Publikováno v:
Journal of Leukocyte Biology. 106:863-877
This study tested the hypothesis that mucosa associated lymphoid tissue 1 (Malt1) deficiency causes osteoporosis in mice by increasing osteoclastogenesis and osteoclast activity. A patient with combined immunodeficiency (CID) caused by MALT1 deficien
Autor:
Kristi Baker, Susan C. Menzies, Edda Fiebiger, Jan Terje Andersen, Jonathan N. Glickman, Lisa K. Kozicky, Laura M. Sly, Algirdas Grevys, Michal Pyzik, Timo Rath, Jonathan J. Hubbard, Inger Sandlie, Richard S. Blumberg, Amit Gandhi, Derry C. Roopenian, Stian Foss, Kine Marita Knudsen Sand
Publikováno v:
The Journal of Experimental Medicine
FcRn and CD32a form a ternary complex under acidic conditions and act together in determining responses to IgG immune complexes. The human autoimmune disease–associated CD32a-H131 variant more avidly forms this ternary complex, leading to greater F
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 3:12-13
Background Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is characterized by chronic inflammation that can occur anywhere along the gastrointestinal (GI) tract, but commonly involves the distal portion of the ileum. Src homology
Publikováno v:
European Journal of Immunology.
Intravenous immunoglobulin (IVIg) is used to treat immune-mediated diseases but its mechanism of action is poorly understood. We have reported that co-treatment with IVIg and lipopolysaccharide activates macrophages to produce large amounts of anti-i
Publikováno v:
Gut Microbes
Inflammatory bowel disease, encompassing both ulcerative colitis and Crohn’s disease, is characterized by chronic, relapsing-remitting gastrointestinal inflammation of unknown etiology. SHIP deficient mice develop fully penetrant, spontaneous ileit
Autor:
Hayley K. Brugger, Laura M. Sly, Keith W. McLarren, Nico van Rooijen, Kevan Jacobson, Eyler N. Ngoh, Lisa K. Kozicky, Shelley B. Weisser, Roger Jen, Jan A. Ehses, Susan C. Menzies, Stuart E. Turvey, Dominika Nackiewicz, Young Lo
Publikováno v:
Gastroenterology, 150(2), 465-476. W.B. Saunders Ltd
Ngoh, E N, Weisser, S B, Lo, Y, Kozicky, L K, Jen, R, Brugger, H K, Menzies, S C, McLarren, K W, Nackiewicz, D, van Rooijen, N, Jacobson, K, Ehses, J A, Turvey, S E & Sly, L M 2016, ' Activity of SHIP, Which Prevents Expression of Interleukin 1 beta, Is Reduced in Patients With Crohn's Disease ', Gastroenterology, vol. 150, no. 2, pp. 465-476 . https://doi.org/10.1053/j.gastro.2015.09.049
Ngoh, E N, Weisser, S B, Lo, Y, Kozicky, L K, Jen, R, Brugger, H K, Menzies, S C, McLarren, K W, Nackiewicz, D, van Rooijen, N, Jacobson, K, Ehses, J A, Turvey, S E & Sly, L M 2016, ' Activity of SHIP, Which Prevents Expression of Interleukin 1 beta, Is Reduced in Patients With Crohn's Disease ', Gastroenterology, vol. 150, no. 2, pp. 465-476 . https://doi.org/10.1053/j.gastro.2015.09.049
Crohn's disease (CD) is associated with a dysregulated immune response to commensal micro-organisms in the intestine. Mice deficient in inositol polyphosphate 5'-phosphatase D (INPP5D, also known as SHIP) develop intestinal inflammation resembling th
BACKGROUND: Primary immune deficiencies are often accompanied by intestinal inflammation. A patient with severe combined immunodeficiency and dramatic inflammation along the gastrointestinal tract was diagnosed with a homozygous mutation in MALT1. Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9ce76ca22e6b2b633b35a8e01b8b51
https://europepmc.org/articles/PMC6508152/
https://europepmc.org/articles/PMC6508152/