Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Susan C. Kirkland"'
Publikováno v:
Journal of Cellular Biochemistry. 112:2170-2178
Cell culture is widely used to study gene or protein changes in response to experimental conditions. The value of such experiments depends on stringent control and understanding of the in vitro environment. Despite well-documented evidence describing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879ec3dc04b4f217b17db41975223bb8
https://doi.org/10.1002/jcb.23143
https://doi.org/10.1002/jcb.23143
Autor:
Susan C. Kirkland, Huijun Ying
Publikováno v:
The Journal of Biological Chemistry
The human colorectal epithelium is maintained by multipotent stem cells that give rise to absorptive, mucous, and endocrine lineages. Recent evidence suggests that human colorectal cancers are likewise maintained by a minority population of so-called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5bce5f8bd30df06a3882ce976b1506
http://europepmc.org/articles/PMC2562061
http://europepmc.org/articles/PMC2562061
Autor:
Susan C. Kirkland, Karen Henderson
Publikováno v:
Journal of Cell Science. 114:2055-2064
The human large intestine is lined by a rapidly renewing epithelial monolayer where cell loss is precisely balanced with cell production. The continuous supply of new cells is produced by undifferentiated multipotent stem cells via a coordinated prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c59724cc5e050915c3fc27d80cd35d
https://doi.org/10.1242/jcs.114.11.2055
https://doi.org/10.1242/jcs.114.11.2055
Autor:
Peter J. Dempsey, Thomas L. Jetton, Jason D. Morrow, Susan C. Kirkland, Vincent C. Daniel, Chris J. Hawkey, Lars Damstrup, Rebecca Chinery, Ramona Graves-Deal, Robert J. Coffey, Raymond N. DuBois
Publikováno v:
Proceedings of the National Academy of Sciences. 94:657-662
Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is overexpressed in neoplastic colonic tissue, is an attractive target to mediate this effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d610d4240bb2a8a904aece55e53f8c
https://doi.org/10.1073/pnas.94.2.657
https://doi.org/10.1073/pnas.94.2.657
Autor:
Susan C. Kirkland, Karen Henderson
Publikováno v:
Differentiation. 60:259-268
Colorectal epithelium is composed of polarised absorptive enterocytes, mucus-producing goblet cells and enteroendocrine cells. All these cell lineages are thought to arise from multipotential stem cells located near the base of the crypt, but the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd043dfed24ccae7312151dfae4e0c9
https://doi.org/10.1046/j.1432-0436.1996.6040259.x
https://doi.org/10.1046/j.1432-0436.1996.6040259.x
Autor:
Susan C. Kirkland, Karen Henderson
Publikováno v:
Journal of Cell Science. 107:1041-1046
Colorectal epithelium is composed of absorptive, mucous and endocrine cells, all of which are considered to arise from a common stem cell located in the crypt base. However, the factors controlling the commitment to differentiate are poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e41e739eda91ee9e3f4c2bf9103c3f
https://doi.org/10.1242/jcs.107.4.1041
https://doi.org/10.1242/jcs.107.4.1041
Publikováno v:
The Journal of Pathology. 170:441-450
The HCA-7 cell line was established from a moderately well differentiated mucinous adenocarcinoma of the colon, which showed histological heterogeneity. This was reflected in the morphological heterogeneity in early passages of the HCA-7 cell line bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bebcfebd7b7d63f5cdc69fb39f74fb9
https://doi.org/10.1002/path.1711700407
https://doi.org/10.1002/path.1711700407
Autor:
Susan C. Kirkland
Publikováno v:
Differentiation. 33:148-155
Colorectal epithelium is composed of a variety of cell types, including absorptive. mucous and endocrine cells. All of these cell types are thought to arise from stem cells located at the base of the crypt. However, the factors which control these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5850f3ac5d607e45f3fec481d61e502a
https://doi.org/10.1111/j.1432-0436.1987.tb01551.x
https://doi.org/10.1111/j.1432-0436.1987.tb01551.x
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 17:91-94
A method of estimating doses from multiple dilutions of an unknown sample in radioimmunoassay is described. It uses a computer program to minimise the root mean square error about a standard curve. The confidence limits of the estimates were evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d3cf3d8e02fe0ca247fa1ab6369fab
https://doi.org/10.1177/000456328001700206
https://doi.org/10.1177/000456328001700206
Autor:
Susan C. Kirkland
Publikováno v:
Cancer. 61:1359-1363
Human colorectal epithelium is composed mainly of columnar, mucous and endocrine cells; origin of these cell lineages from a multi-potential stem cell at the base of the crypt (the Unitarian hypothesis) has been proposed but not yet demonstrated. Gut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c798c8b52570080dd4a845918d4ada8
https://doi.org/10.1002/1097-0142(19880401)61:7<1359::aid-cncr2820610714>3.0.co
https://doi.org/10.1002/1097-0142(19880401)61:7<1359::aid-cncr2820610714>3.0.co