Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Susan C. Frost"'
Autor:
Christopher J. Frost, Andrea Ramirez-Mata, Ram B. Khattri, Matthew E. Merritt, Susan C. Frost
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Hypoxia is a common feature of most solid tumors, one that favors tumor progression and limits treatment effectiveness. Targeting hypoxia has long been a goal in cancer therapy, by identifying factors that reverse or ameliorate the effects of hypoxia
Externí odkaz:
https://doaj.org/article/112d1d5fff75411487fee40004ef91f5
Publikováno v:
Molecules, Vol 23, Iss 5, p 1045 (2018)
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer. In solid tumors, continuously dividing cells create hypox
Externí odkaz:
https://doaj.org/article/11b4618609c844e5bb48923a66037b69
Publikováno v:
Metabolites, Vol 8, Iss 1, p 19 (2018)
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of n
Externí odkaz:
https://doaj.org/article/686bc23d29e34ed0a5d2a3ed2902e301
Autor:
Mam Y Mboge, Zhijuan Chen, Alyssa Wolff, John V Mathias, Chingkuang Tu, Kevin D Brown, Murat Bozdag, Fabrizio Carta, Claudiu T Supuran, Robert McKenna, Susan C Frost
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207417 (2018)
Carbonic anhydrases (CAs) have been linked to tumor progression, particularly membrane-bound CA isoform IX (CA IX). The role of CA IX in the context of breast cancer is to regulate the pH of the tumor microenvironment. In contrast to CA IX, expressio
Externí odkaz:
https://doaj.org/article/57c7274cabf84022a0841512b8b5930b
Autor:
Jacob T. Andring, Zaihui Zhang, Mam Y. Mboge, Srishti Singh, Susan C. Frost, Robert McKenna, Jacob Combs, Alyssa Wolff, Chingkuang Tu
Publikováno v:
J Med Chem
Carbonic anhydrase IX (CAIX) is considered a target for therapeutic intervention in solid tumors. In this study, the efficacy of the inhibitor, 4-(3-(2,4-difluorophenyl)-oxoimidazolidin-1-yl)benzenesulfonamide (SLC-149), is evaluated on CAIX and a CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b1095704f1bdec1524aa4c4d0ee922
https://pubmed.ncbi.nlm.nih.gov/33523653
https://pubmed.ncbi.nlm.nih.gov/33523653
Autor:
Christopher J. Frost, Susan C. Frost, Andrea S Ramirez-Mata, John V. Mathias, Riley O’Donnell, Mam Y. Mboge, Adam Bullock, Julie Davila
Publikováno v:
Curr Top Biochem Res
β-caryophyllene (BCP) exhibits anti-proliferative properties in cancer cells. Here, we examine the hypothesis that BCP induces membrane remodeling. Our data show that high concentrations of BCP increase membrane permeability of human breast cells (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee68cf3eab80f53eed78944cfaa25f94
https://doi.org/10.1101/569558
https://doi.org/10.1101/569558
Autor:
Claudiu T. Supuran, Susan C. Frost, Christopher J. Frost, Zhijuan Chen, Mam Y. Mboge, Coy D. Heldermon, Lingbao Ai, Alyssa Wolff, Kevin D. Brown, Robert McKenna, Murat Bozdag, Fabrizio Carta, Daniel Khokhar
The most aggressive and invasive tumor cells often reside in hypoxic microenvironments and rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative phosphorylation to glycolysis, along with up-regulation of the glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae3306237f23bc1ce915baa0409552
Publikováno v:
Topics in anti-cancer research. 5
The microenvironment within a solid tumor is heterogeneous with regions being both acidic and hypoxic. As a result of this, cancer cells upregulate genes that allow survival in such environments. Some of these genes are pH regulatory factors, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::051b093e6b965cfafb61410f94d754b7
https://pubmed.ncbi.nlm.nih.gov/30272043
https://pubmed.ncbi.nlm.nih.gov/30272043
Autor:
Zhijuan Chen, Susan C. Frost, Chingkuang Tu, John V. Mathias, Alyssa Wolff, Claudiu T. Supuran, Mam Y. Mboge, Murat Bozdag, Kevin D. Brown, Robert McKenna, Fabrizio Carta
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207417 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207417 (2018)
Carbonic anhydrases (CAs) have been linked to tumor progression, particularly membrane-bound CA isoform IX (CA IX). The role of CA IX in the context of breast cancer is to regulate the pH of the tumor microenvironment. In contrast to CA IX, expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b5cad3b25766d2042634eafff39304
https://pubmed.ncbi.nlm.nih.gov/30452451
https://pubmed.ncbi.nlm.nih.gov/30452451
Autor:
Zhijuan Chen, Coy D. Heldermon, Chingkuang Tu, Mam Y. Mboge, Lingbao Ai, Susan C. Frost, Kevin D. Brown, Robert McKenna
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199476 (2018)
PLoS ONE, Vol 13, Iss 7, p e0199476 (2018)
Carbonic anhydrase IX (CAIX) and XII (CAXII) are transmembrane proteins that are associated with cancer progression. We have previously described the catalytic properties of CAIX in MDA-MB-231 breast cancer cells, a line of cells that were derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009a00542fd12fbaa83f19d7ca860413
http://europepmc.org/articles/PMC6028082
http://europepmc.org/articles/PMC6028082