Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Susan C. Fagan"'
Autor:
Abdulkarim Alshammari, Yohan Han, Timothy W. Jones, Bindu Pillai, Duo Zhang, Adviye Ergul, Payaningal R. Somanath, Susan C. Fagan
Publikováno v:
Life, Vol 13, Iss 6, p 1274 (2023)
Background: Sustained microglial activation contributes to the development of post-stroke cognitive impairment (PSCI). Compound 21 (C21), an angiotensin II type 2 receptor agonist, has shown some neurovascular protection after stroke. This study aime
Externí odkaz:
https://doaj.org/article/88b7e765fb01430c81dc58d5c8929af8
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Introduction Unfortunately, over 40% of stroke victims have pre-existing diabetes which not only increases their risk of stroke up to 2–6 fold, but also worsens both functional recovery and the severity of cognitive impairment. Our lab has
Externí odkaz:
https://doaj.org/article/e117b25a255e4edab6ff8353944d571e
Publikováno v:
Drugs in R&D, Vol 19, Iss 2, Pp 93-115 (2019)
Abstract Dementia affects all domains of cognition. The relentless progression of the disease after diagnosis is associated with a 98% incidence of neuropsychiatric symptoms (NPS) at some point in the disease, including depression, psychosis, agitati
Externí odkaz:
https://doaj.org/article/658df1a9576544f9a0c4e28631960ca6
Autor:
Heba A. Ahmed, Tauheed Ishrat, Bindu Pillai, Abdelrahman Y. Fouda, Mohammed A. Sayed, Wael Eldahshan, Jennifer L. Waller, Adviye Ergul, Susan C. Fagan
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Abstract Background With the aging population, the prevalence and incidence of cerebrovascular disease will continue to rise, as well as the number of individuals with vascular cognitive impairment/dementia (VCID). No specific FDA-approved treatments
Externí odkaz:
https://doaj.org/article/656ea8b917cd41a0b5dede0fe73be8f9
Autor:
Amritha A. Candadai, Fang Liu, Arti Verma, Mir S. Adil, Moaddey Alfarhan, Susan C. Fagan, Payaningal R. Somanath, S. Priya Narayanan
Publikováno v:
Cells, Vol 10, Iss 11, p 2938 (2021)
Visual dysfunction resulting from optic neuritis (ON) is one of the most common clinical manifestations of multiple sclerosis (MS), characterized by loss of retinal ganglion cells, thinning of the nerve fiber layer, and inflammation to the optic nerv
Externí odkaz:
https://doaj.org/article/84d2577ff1f94fce89aef8faa6029b1e
Autor:
LaDonya Jackson-Cowan, Wael Eldahshan, Selin Dumanli, Guangkuo Dong, Sarah Jamil, Yasir Abdul, Waleed Althomali, Babak Baban, Susan C. Fagan, Adviye Ergul
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1356 (2021)
About 70% of stroke victims present with comorbid diseases such as diabetes and hypertension. The integration of comorbidities in pre-clinical experimental design is important in understanding the mechanisms involved in the development of stroke inju
Externí odkaz:
https://doaj.org/article/3f4c0da3dbb14996b2b6325251cfb2f8
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 3, p 876 (2018)
For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their hypo
Externí odkaz:
https://doaj.org/article/f907b8fc740e499f955db00c61a65549
Autor:
Tauheed Ishrat, Anna Kozak, Ahmed Alhusban, Bindu Pillai, Maribeth H. Johnson, Azza B. El-Remessy, Adviye Ergul, Susan C. Fagan
Publikováno v:
Stroke Research and Treatment, Vol 2014 (2014)
Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candes
Externí odkaz:
https://doaj.org/article/86a8acfdb8f24dad8a868813947047a2
Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke
Autor:
Abdelrahman Y. Fouda, Heba A. Ahmed, Bindu Pillai, Anna Kozak, Trevor Hardigan, Adviye Ergul, Susan C. Fagan, Tauheed Ishrat
Publikováno v:
Neurochem Int
We and others have previously shown that angiotensin II receptor type 2 receptor (AT2R) is upregulated in the contralesional hemisphere after stroke in normoglycemic Wistar rats. In this study, we examined the expression of AT2R in type 2 diabetic Go
Autor:
Abdulkarim Alshammari, Tim W Jones, Bindu Pillai, Pradip Kamat, Mohammad B Khan, David C Hess, Asamoah Bosomtwi, Adviye Ergul, Susan C Fagan
Publikováno v:
Stroke. 53
Hypertension and aging are leading risk factors for stroke and cognitive decline. Animal models fail to capture the complex interplay between these two pathophysiologic processes, limiting human translation of interventions. In the current study, we