Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Susan C Kandarian"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87776 (2014)
Existing data suggest that NF-kappaB signaling is a key regulator of cancer-induced skeletal muscle wasting. However, identification of the components of this signaling pathway and of the NF-κB transcription factors that regulate wasting is far from
Externí odkaz:
https://doaj.org/article/1ab664ba8dcc4bb8937e272c170eeb1c
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51478 (2012)
NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that B
Externí odkaz:
https://doaj.org/article/8be056a0547a4c7b96b7c7712c7c32fa
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16171 (2011)
Skeletal muscle atrophy is a debilitating condition associated with weakness, fatigue, and reduced functional capacity. Nuclear factor-kappaB (NF-κB) transcription factors play a critical role in atrophy. Knockout of genes encoding p50 or the NF-κB
Externí odkaz:
https://doaj.org/article/83f0ad947c1b43a980cfa27cf8877bde
Autor:
John D. Ganey, Robert W. Jackman, Susan C. Kandarian, Andrew Judge, Jesse D. Moreira, Andrea E. Delitto, Sarah M. Judge, Rachel L. Nosacka
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 9:1109-1120
BACKGROUND Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ad5e70aa899a7604418251dbd612722
https://doi.org/10.1002/jcsm.12346
https://doi.org/10.1002/jcsm.12346
Autor:
Susan C. Kandarian, Rachel L. Nosacka, Andrea E. Delitto, Andrew R. Judge, Sarah M. Judge, John D. Ganey, Jesse D. Moreira, Robert W. Jackman
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 6, Pp 1109-1120 (2018)
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 6, Pp 1109-1120 (2018)
Background Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c27538cf3c79e0e91d180b41305f06c
http://europepmc.org/articles/PMC6240747
http://europepmc.org/articles/PMC6240747
Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture
Autor:
Jess Floro, Maythita Eiampikul, Robert W. Jackman, Brian Zitin, Danielle N. Seto, Khalid El-Jack, Susan C. Kandarian, Rei Yoshimine
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology, Vol 10 (2019)
Cachexia is strongly associated with a poor prognosis in cancer patients but the biological trigger is unknown and therefore no therapeutics exist. The loss of skeletal muscle is the most deleterious aspect of cachexia and it appears to depend on sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caec9c3b77fb37628370c0ca4d0ba830
http://europepmc.org/articles/PMC6499183
http://europepmc.org/articles/PMC6499183
Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture
Autor:
Jess Floro, Kahlid El-Jack, Susan C. Kandarian, Rei Yoshimine, Maythita Eiampikul, Brian Zitin, Danielle N. Seto, Robert W. Jackman
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cachexia is strongly associated with a poor prognosis in cancer patients but the biological trigger is unknown and therefore no therapeutics exist. The loss of skeletal muscle is the most deleterious aspect of cachexia and it appears to depend on sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52900ee4cac645c4aff9fa990d32d9b9
https://www.frontiersin.org/article/10.3389/fphys.2017.00738/full
https://www.frontiersin.org/article/10.3389/fphys.2017.00738/full
Publikováno v:
Experimental Physiology. 98:19-24
The nuclear factor-κB (NF-κB) signalling pathway is a necessary component of adult skeletal muscle atrophy resulting from systemic illnesses or disuse. Studies showing a role for the NF-κB pathway in muscle disuse include unloading, denervation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a19b644cd781b755a93f944acfa6c9
https://doi.org/10.1113/expphysiol.2011.063321
https://doi.org/10.1113/expphysiol.2011.063321
Autor:
Chia-Ling Wu, Michael Gustin, Jamie K. Lim, Susan C. Kandarian, Takuo Yamaki, Robert W. Jackman
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C135-C142
Muscle atrophy can be triggered by systemic illnesses that are associated with elevated proinflammatory/catabolic cytokines, which, in turn, are thought to contribute to muscle wasting. In this study, we found that the prototypical NF-κB transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61672b175e24a943c805470db29254d
https://doi.org/10.1152/ajpcell.00111.2012
https://doi.org/10.1152/ajpcell.00111.2012
Autor:
Min Y. Cho, Joseph G. Reynolds, Hartmut Weiler, Francisco J. Naya, Chia-Ling Wu, Susan C. Kandarian, Ondra M. Kielbasa, Christine M. Snyder
Publikováno v:
The FASEB Journal. 25:2276-2286
The calcium-calmodulin-regulated protein phosphatase calcineurin plays an important regulatory role in muscle differentiation, fiber-type determination, hypertrophy, and muscle regeneration. Because calcineurin functions in numerous processes in musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0cf3d4fea8159605eb67aaef267219
https://doi.org/10.1096/fj.10-169219
https://doi.org/10.1096/fj.10-169219