Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Susan C, Short"'
Autor:
Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F. Bruns, Khaja Syed, James A. Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S. Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A. Care, Luisa Cutillo, David R. Westhead, Susan C. Short, Michael D. Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G. W. Verhaak, Lucy F. Stead
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing da
Externí odkaz:
https://doaj.org/article/190c474079fc465a883fccd59c89b7b7
Autor:
Nektarios K. Mazarakis, Stephen D. Robinson, Priyank Sinha, Christos Koutsarnakis, Spyridon Komaitis, George Stranjalis, Susan C. Short, Paul Chumas, Georgios Giamas
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 46, Iss , Pp 100761- (2024)
High grade gliomas are the most common primary aggressive brain tumours with a very poor prognosis and a median survival of less than 2 years. The standard management protocol of newly diagnosed glioblastoma patients involves surgery followed by radi
Externí odkaz:
https://doaj.org/article/ad5baf5a520642be8dd50b97972492c0
Autor:
Divyalakshmi Bhaskaran, Joshua Savage, Amit Patel, Fiona Collinson, Rhys Mant, Florien Boele, Lucy Brazil, Sara Meade, Peter Buckle, Siân Lax, Lucinda Billingham, Susan C. Short
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with tumours showing O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation represent
Externí odkaz:
https://doaj.org/article/eab0ef4f27614cabaf65f9eab32b4134
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent gl
Externí odkaz:
https://doaj.org/article/c015455051d141358c38ab0af93970d0
Autor:
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure w
Externí odkaz:
https://doaj.org/article/de1a4f0585554636831662f1395174a1
Autor:
Florien W Boele, Sean Butler, Emma Nicklin, Helen Bulbeck, Lucy Pointon, Susan C Short, Louise Murray
Publikováno v:
Palliative Medicine. 37:834-843
Background: Patients with glioblastoma have a poor prognosis and treatment is palliative in nature from diagnosis. It is therefore critical that the benefits and burdens of treatments are clearly discussed with patients and caregivers. Aim: To explor
Autor:
Moritz W. J. Schramm, Stuart Currie, Ming-te Lee, Laurent J. Livermore, Sandeep P. Solanki, Ryan K. Mathew, Heiko Wurdak, Mihaela Lorger, Chris Twelves, Susan C. Short, Aruna Chakrabarty, Paul Chumas
Publikováno v:
Journal of Neuro-Oncology. 161:451-467
Introduction Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growi
Autor:
Jennifer Williams, Gary Shaw, Tereza Andreou, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Heiko Wurdak, Susan C Short, Mihaela Lorger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratu
Externí odkaz:
https://doaj.org/article/326e3a4093304c04a49a76c0b552d643
Autor:
Susan C Short
Publikováno v:
Neuro Oncol
BACKGROUND: Extracellular vesicles (EVs) play an important role in cell–cell communication, and tumor-derived EVs circulating in patient blood can serve as biomarkers. Here, we investigated the potential role of plasma EVs in meningioma patients fo
Autor:
Ben Fulton, Susan C. Short, Allan James, Stefan Nowicki, Catherine McBain, Sarah Jefferies, Caroline Kelly, Jon Stobo, Anna Morris, Aoife Williamson, Anthony J. Chalmers
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 8, Iss C, Pp 12-16 (2018)
Glioblastoma has a dismal prognosis and molecular targeted agents have failed to improve outcomes to date. PARADIGM-2 is a phase I dose escalation study evaluating olaparib plus radiotherapy ± temozolomide in newly diagnosed glioblastoma, using MGMT
Externí odkaz:
https://doaj.org/article/69f6ccf5e2064209ba6e1bb4069d7193