Výsledky vyhledávání - "Susan Burbridge"

Mechanism of lonidamine inhibition of the CFTR chloride channel

Autor: Paul Linsdell, Angie C Lewis, Xiandi Gong, Patrick Y.D. Wong, Susan Burbridge

Publikováno v: British Journal of Pharmacology. 137:928-936

1. The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is blocked by a broad range of organic anionic compounds. Here we investigate the effects of the indazole compound lonidamine on CFTR channels expressed in mammalian cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50f087495e573fd3f3363e9ede19cb71
https://doi.org/10.1038/sj.bjp.0704932

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Virulence of patient and water isolates of Legionella pneumophila in guinea pigs and mouse L929 cells varies with bacterial genotype

Autor: Susan Burbridge, Rachel Fernandez, Thomas J. Marrie, G. Bezanson, David Haldane

Publikováno v: Canadian Journal of Microbiology. 40:426-431

Thirteen isolates of Legionella pneumophila serogroup 1 (five from patients, eight from water) were screened for their virulence in guinea pigs after intraperitoneal injection and for their infectivity in L929 mouse cells. Since these isolates includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d551471d759b0f6ea3a086480cc5ec
https://doi.org/10.1139/m94-070

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Diverse populations of Legionella pneumophila present in the water of geographically clustered institutions served by the same water reservoir

Autor: C Yoell, David Haldane, Thomas J. Marrie, Susan Burbridge, G. Bezanson

Publikováno v: Journal of Clinical Microbiology. 30:570-576

We cultured potable water from seven institutions (six hospitals and one medical school) every 2 weeks for 6 months for Legionella pneumophila. All of the institutions were located close to each other and received water from the same freshwater sourc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d521ad1122abf1ff8a4c793f9a87c5
https://doi.org/10.1128/jcm.30.3.570-576.1992

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Colonisation of the respiratory tract with Legionella pneumophila for 63 days before the onset of pneumonia

Autor: G. Bezanson, David Haldane, Thomas J. Marrie, Susan Burbridge

Publikováno v: Journal of Infection. 24:81-86

We report the case of a 70-year-old man who was admitted to hospital A 66 days before developing Legionella pneumophila pneumonia 6 days after open heart surgery at hospital C. The strain of L. pneumophila recovered from the patient's sputum was of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7e5c42baf8dbf968b9cfe5a7cc72e7
https://doi.org/10.1016/0163-4453(92)91094-r

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Genomic Stability of Legionella pneumophila Isolates Recovered from Two Cardiac Transplant Patients with Nosocomial Legionnaires' Disease

Autor: Shaun Tyler, Thomas J. Marrie, G. Bezanson, Susan Burbridge, Wendy M. Johnson

Publikováno v: Journal of Clinical Microbiology. 32:3085-3087

Pulsed-field gel electrophoresis revealed that multiple consecutive isolates of Legionella pneumophila from two cardiac transplant patients remained genomically stable, despite exposure to host defenses and antimicrobial agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0a133f2227fecd353ce250adf84b39
https://doi.org/10.1128/jcm.32.12.3085-3087.1994

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Molecular determinants of Au(CN)2− binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl− channel pore

Autor: Paul Linsdell, Xiandi Gong, Elizabeth A. Cowley, Susan Burbridge

Lyotropic anions with low free energy of hydration show both high permeability and tight binding in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel pore. However, the molecular bases of anion selectivity and anion binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0c4f0af38119bb68960abb82c8a98e
https://europepmc.org/articles/PMC2290216/

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Potable water and nosocomial Legionnaires' disease--check water from all rooms in which patient has stayed

Autor: G. Bezanson, David Haldane, J. Joly, Wendy M. Johnson, Susan Burbridge, S. Tyler, Thomas J. Marrie

Publikováno v: Epidemiology and infection. 114(2)

SummaryWe studied 7 patients with nosocomial Legionnaires' disease to determine the relationship between isolates ofLegionella pneumophilarecovered from potable water and those recovered from patients. Potable water was cultured from all rooms in whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592e1145fb282bc132acb2fc97113c79
https://pubmed.ncbi.nlm.nih.gov/7705490

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Legionnaires' disease in cardiac transplant patients: a cell-mediated immune response develops despite cyclosporine therapy

Autor: Susan M. Logan, David W. Hoskin, Linda Yates, Risini Weeratna, Paul S. Hoffman, Thomas J. Marrie, Susan Burbridge, David Haldane, G. Bezanson

Publikováno v: The Journal of infectious diseases. 168(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace8e9db4bf40a3540456e6ee3af4dd
https://pubmed.ncbi.nlm.nih.gov/8336002

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In situ colonization of polyvinyl chloride, brass, and copper by Legionella pneumophila

Autor: Thomas J. Marrie, G. Bezanson, David Haldane, Susan Burbridge

Publikováno v: Canadian journal of microbiology. 38(4)

A sampling device (Robbins device) was used to expose brass, copper, and polyvinyl chloride plugs to potable water contaminated by Legionella pneumophila serogroup 1. Plugs were removed at approximately 1-week intervals and cultured. The colonization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61194798672acfaf955235ca9c971e85
https://pubmed.ncbi.nlm.nih.gov/1611559

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