Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Susan Bane Hastie"'
1
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds
Autor: Li Sun, Chii M. Lin, Amy Pyluck, Susan Bane Hastie, Kuo Hsiung Lee, Ernest Hamel
Publikováno v: Journal of Medicinal Chemistry. 36:1474-1479
Three series of novel thiocolchicine analogs, N-acyl-, N-aroyl-, and N-(substituted benzyl)-deacetylthiocolchicinoids, have been synthesized and evaluated for their cytotoxicity against various tumor cell lines, especially solid tumor cell lines, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb1a390a2bbbeaa78be4fb4667a0974
https://doi.org/10.1021/jm00062a021
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2
Conformational analysis of colchicinoids containing an electron-deficient aromatic ring on the B ring
Autor: Erica A. Pyles, Susan Bane Hastie
Publikováno v: The Journal of Organic Chemistry. 58:2751-2759
A dinitrophenyl substituent at the C-7 position of N-deacetylcolchicine and N-deacetylisocolchicine was shown to perturb the 1 H NMR and circular dichroic spectra of colchicinoid ring systems. The perturbations were explained by an interaction betwee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd8aebf158e9592631789e5684c1423d
https://doi.org/10.1021/jo00062a016
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3
'Combretatropones'—hybrids of combretastatin and colchicine. Synthesis and biochemical evaluation
Autor: J.E. Bernardo, Timothy L. Macdonald, Susan Bane Hastie, Q. Yan, C.J. Andres
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:565-570
The synthesis and biological evaluation is presented for a new class of tubulin-targeting agents, termed “combretatropones,” that incorporate the 1,2-diaryl ethane nucleus of combretastatin and the tropone moiety of colchicine. Compounds 1 and 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c2abc6ad6f0564b5caedad5486a25a3
https://doi.org/10.1016/s0960-894x(01)81230-0
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5
ChemInform Abstract: Synthesis, Photochemical Decomposition, and Tubulin Binding of 10- Azido-10-demethoxycolchicine and 9-Azido-9-demethoxyisocolchicine
Autor: Susan Bane Hastie, Marianne E. Staretz
Publikováno v: ChemInform. 22
We describe the synthesis and photochemical decomposition of a potential C ring photoaffinity label, 10-azido-10-demethoxycolchicine (1), and the biochemically inactive analogue 9-azido-9-demethoxyisocolchicine (2). The possible use of 1 as a photoaf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19f4368d081f88f1da3c528c85c7fb18
https://doi.org/10.1002/chin.199121151
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7
Role of the B-ring substituent in the fluorescence of colchicinoid-tubulin and allocolchicinoid-tubulin complexes
Autor: Erica A. Pyles, Susan Bane Hastie
Publikováno v: Biochemistry. 31:7086-7093
Fluorescence spectra of several B-ring derivatives of allocolchicine in a variety of solvents have been obtained. The quantum yields of the allocolchicine derivatives decreased with amine substitution at the C-7 position (R = H > NH2 >> NHCH3 > N(CH3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96cdd4b6cac52162733866a154840a8
https://doi.org/10.1021/bi00146a009
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8
Effect of B-ring substituents on absorption and circular dichroic spectra of colchicine analogs
Autor: Richard P. Rava, Erica A. Pyles, Susan Bane Hastie
Publikováno v: Biochemistry. 31:2034-2039
Near-ultraviolet absorption and circular dichroic spectra of several B-ring derivatives of colchicine have been obtained in a variety of solvents. The spectra of the molecules in solvent were analyzed and compared with spectra of the molecules bound
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e520005c82818eb14a62523f99a0cd
https://doi.org/10.1021/bi00122a020
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9
SYNTHESIS AND EVALUATION OF 2-DIAZO-3,3,3-TRIFLUOROPROPANOYL DERIVATIVES OF COLCHICINE AND PODOPHYLLOTOXIN AS PHOTOAFFINITY LABELS: REACTIVITY, PHOTOCHEMISTRY, AND TUBULIN BINDING
Autor: Klaus M. Hahn, Susan Bane Hastie, Richard J. Sundberg
Publikováno v: Photochemistry and Photobiology. 55:17-27
Derivatives of the tubulin polymerization inhibitors colchicine and podophyllotoxin bearing the photoreactive 2-diazo-3,3,3-trifluoropropanoyl (DTFP) group were synthesized for evaluation as potential photoaffinity labels of the tubulin binding site.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46faf42301cc63aa9adb44cdfd55d6f
https://doi.org/10.1111/j.1751-1097.1992.tb04204.x
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10
Synthesis, photochemical decomposition, and tubulin binding of 10-azido-10-demethoxycolchicine and 9-azido-9-demethoxyisocolchicine
Autor: Susan Bane Hastie, Marianne E. Staretz
Publikováno v: The Journal of Organic Chemistry. 56:428-432
We describe the synthesis and photochemical decomposition of a potential C ring photoaffinity label, 10-azido-10-demethoxycolchicine (1), and the biochemically inactive analogue 9-azido-9-demethoxyisocolchicine (2). The possible use of 1 as a photoaf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18ef83df5cb3fd8454a907ed4cb94c2d
https://doi.org/10.1021/jo00001a080
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