Výsledky vyhledávání - "Susan B. McKay"

Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery

Autor: Crina M. Orac, R. Thomas Boyd, Dennis B. McKay, Michael X. Zhu, Raed A. El-Hajj, Stephen C. Bergmeier, Damon D. Reed, Brandon J. Henderson, Chenglong Li, Ryan E. Pavlovicz, Tatiana F. González-Cestari, Susan B. McKay, Aravinda B. Pulipaka

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 328:504-515

Allosteric modulation of nAChRs is considered to be one of the most promising approaches for drug design targeting nicotinic acetylcholine receptors (nAChRs). We have reported previously on the pharmacological activity of several compounds that seem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1ed6812b7bf07e01de04c8c04b8be5
https://doi.org/10.1124/jpet.108.144576

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Pharmacological and immunological identification of native α7 nicotinic receptors: Evidence for homomeric and heteromeric α7 receptors

Autor: Dennis B. McKay, Raed A. El-Hajj, Susan B. McKay

Publikováno v: Life Sciences. 81:1317-1322

Controversy surrounds the expression of alpha7 nicotinic acetylcholine receptors (nAChRs) in adrenal chromaffin cells. In these studies, alpha7 nAChRs expressed in bovine adrenal chromaffin cells are investigated. Using radiolabeled ligand binding te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8abca42ceaf1964529cbb73fff82e5a
https://doi.org/10.1016/j.lfs.2007.08.039

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Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development

Autor: Stephen C. Bergmeier, Dennis B. McKay, Susan B. McKay, Crina M. Orac, Michael X. Zhu, Kristjan M. Arason, Peter W. Swaan, Tatiana F. González-Cestari, Darrell L. Bryant, Aravinda B. Pulipaka, Cheng Chang, Raed A. El-Hajj

Publikováno v: Molecular Pharmacology. 71:1288-1297

As a novel approach to drug discovery involving neuronal nicotinic acetylcholine receptors (nAChRs), our laboratory targeted nonagonist binding sites (i.e., noncompetitive binding sites, negative allosteric binding sites) located on nAChRs. Cultured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5b8b472205366d32e4e0ca92a975f5
https://doi.org/10.1124/mol.106.033233

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Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4* nicotinic acetylcholine receptors through modifications to the ester

Autor: Susan B. McKay, Stephen C. Bergmeier, Darrell L. Bryant, Dennis B. McKay, K. A. Ismail, Kristjan M. Arason

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:3739-3742

The development of novel agents for the differentiation of neuronal nicotinic acetylcholine receptors (nAChRs) is important for the treatment of a variety of pathological conditions. We have prepared and evaluated a number of simpler analogues of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb266db48f9cf757dec018f1b022399
https://doi.org/10.1016/j.bmcl.2004.05.001

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A Highly Conserved Cytoplasmic Cysteine Residue in the α4 Nicotinic Acetylcholine Receptor Is Palmitoylated and Regulates Protein Expression*

Autor: Jordan I. Robson, Gregg B. Wells, Muhammad Nasir, Rene Anand, Gerald Ponath, Susan B. McKay, Stephanie A. Amici

Nicotinic acetylcholine receptor (nAChR) cell surface expression levels are modulated during nicotine dependence and multiple disorders of the nervous system, but the mechanisms underlying nAChR trafficking remain unclear. To determine the role of cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d16cb3cb2b8e3a0a95cf6ea41b20c0
https://europepmc.org/articles/PMC3391155/

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Comparison of the effects of antimitotic drugs on α-tubulin mRNA, microtubules and nicotinic receptor-mediated catecholamine secretion in adrenal chromaffin cells in culture

Autor: Dennis B. McKay, Hyangja Gu, Allan M. Burkman, Susan B. McKay

Publikováno v: General Pharmacology: The Vascular System. 25:439-446

1. 1. Four hour treatments of adrenal chromaffin cells with colchicine (10, 100 μM and 1 mM), tubulozole (10 μM) or podophyllotoxin (100 μM) decreases α-tubulin mRNA content. Vinblastine (10 μM) and taxol (10 μM), however, do not decrease α-tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7b7e733347f3e93705899de7203cc7
https://doi.org/10.1016/0306-3623(94)90194-5

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Evidence for Constitutive Expression of Bovine Adrenal a3β4* Nicotinic Acetylcholine Receptors

Autor: R. Benjamin Free, R. Thomas Boyd, Susan B. McKay, Dennis B. McKay

Publikováno v: Annals of the New York Academy of Sciences. 971:145-147

Many pathological conditions involve alterations in expression of nicotinic acetylcholine receptors (nAChRs). The following studies were designed to investigate cellular mechanisms involved with expression and turnover of alpha3beta4* nAChRs. These s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c774242a1912d06a9dd448598c98993
https://doi.org/10.1111/j.1749-6632.2002.tb04450.x

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Nicotinic Acetylcholine Receptor Alterations in Autism Spectrum Disorders – Biomarkers and Therapeutic Targets

Autor: Stephanie A. Amici, Jordan I. Robson, Rene Anand, Susan B. McKay, Muhammad Nasir, Gerald Ponath

Publikováno v: Autism-A Neurodevelopmental Journey from Genes to Behaviour

Autism Spectrum Disorders (ASD) are a set of complex neurodevelopmental disorders defined behaviorally by impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior and a restricted range of interest (Fombonne, 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319297ff4444675529992f805a60972d
http://www.intechopen.com/articles/show/title/nicotinic-acetylcholine-receptor-alterations-in-autism-spectrum-disorders-biomarkers-and-therapeutic

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Evidence for the involvement of adenomatous polyposis coli (APC) protein in maintaining cellular distributions of α3β4 nicotinic receptors

Autor: Tatiana F. González-Cestari, Srichan Phornchirasilp, R. Thomas Boyd, Dennis B. McKay, Tulaya Potaros, Susan B. McKay

Publikováno v: Neuroscience letters. 489(2)

Evidence exists supporting the involvement of adenomatous polyposis coli (APC) protein in the assembly of neuronal nicotinic acetylcholine receptors (nAChRs) in the postsynaptic complex. In the following studies, the effects of APC protein on cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddeff483c553481d03ac75fbf13d7c22
https://pubmed.ncbi.nlm.nih.gov/21138757

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Presynaptic Targeting of α4β2 Nicotinic Acetylcholine Receptors Is Regulated by Neurexin-1β*

Autor: Jayaraman Rao, Shi-Bin Cheng, Jon Lindstrom, Magdalen W. Treuil, Susan B. McKay, Stephanie A. Amici, Rene Anand, Xiao-Qin Ren

The mechanisms involved in the targeting of neuronal nicotinic acetylcholine receptors (AChRs), critical for their functional organization at neuronal synapses, are not well understood. We have identified a novel functional association between alpha4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddffc7fc5a3d0330573e8ad9c661450
https://europepmc.org/articles/PMC2749099/

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