Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Susan A. Leonhardt"'
1
Akademický článek
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
Autor: Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal K. Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (IC
Externí odkaz: https://doaj.org/article/b42d4618236b4cabb367d4bb3ff2f26d
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2
Akademický článek
A quantized mechanism for activation of pannexin channels
Autor: Yu-Hsin Chiu, Xueyao Jin, Christopher B. Medina, Susan A. Leonhardt, Volker Kiessling, Brad C. Bennett, Shaofang Shu, Lukas K. Tamm, Mark Yeager, Kodi S. Ravichandran, Douglas A. Bayliss
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conduct
Externí odkaz: https://doaj.org/article/2fd253debe324fffb44a894dc4d37c5c
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3
Akademický článek
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
Autor: Adishesh K Narahari, Alex JB Kreutzberger, Pablo S Gaete, Yu-Hsin Chiu, Susan A Leonhardt, Christopher B Medina, Xueyao Jin, Patrycja W Oleniacz, Volker Kiessling, Paula Q Barrett, Kodi S Ravichandran, Mark Yeager, Jorge E Contreras, Lukas K Tamm, Douglas A Bayliss
Publikováno v: eLife, Vol 10 (2021)
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local intercellular signaling. However, to date, there has bee
Externí odkaz: https://doaj.org/article/c4cc7f86651745e69bab242b4d3678d0
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6
ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
Autor: Susan A. Leonhardt, Kodi S. Ravichandran, Adishesh K. Narahari, Patrycja W. Oleniacz, Jorge E. Contreras, Paula Q. Barrett, Christopher B. Medina, Volker Kiessling, Yu-Hsin Chiu, Lukas K. Tamm, Pablo S. Gaete, Alex J. B. Kreutzberger, Mark Yeager, Xueyao Jin, Douglas A. Bayliss
Publikováno v: eLife
eLife, Vol 10 (2021)
Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local intercellular signaling. However, to date, there has bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbdf10b509080a8255999d770b2e808
http://europepmc.org/articles/PMC7806264
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7
A Constitutively Closed Pannexin1 Channel in Lipid Bilayer Nanodiscs Assembles as a Large-Pore Heptamer
Autor: Yu-Hsin Chiu, William E. McIntire, Brad C. Bennett, Michael D. Purdy, Susan A. Leonhardt, Mark Yeager, Xueyao Jin, Douglas A. Bayliss
SUMMARYPannexin 1 (Panx1) channels are widely expressed and play important roles in apoptotic cell clearance, inflammation, blood pressure regulation, neurological disorders, opiate withdrawal, and cancer progression and metastasis. We performed (1)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae809aa9637ab6003175c91f42bb74f8
https://doi.org/10.1101/2020.12.31.425019
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8
A quantized mechanism for activation of pannexin channels
Autor: Brad C. Bennett, Xueyao Jin, Lukas K. Tamm, Volker Kiessling, Kodi S. Ravichandran, Susan A. Leonhardt, Christopher B. Medina, Shaofang Shu, Yu-Hsin Chiu, Mark Yeager, Douglas A. Bayliss
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Pannexin 1 (PANX1) subunits form oligomeric plasma membrane channels that mediate nucleotide release for purinergic signalling, which is involved in diverse physiological processes such as apoptosis, inflammation, blood pressure regulation, and cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6de0fcda49b67e96e764f59dc5fccb
https://doaj.org/article/2fd253debe324fffb44a894dc4d37c5c
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10
Binding of β4γ5 by Adenosine A1 and A2A Receptors Determined by Stable Isotope Labeling with Amino Acids in Cell Culture and Mass Spectrometry
Autor: William E. McIntire, Mark Yeager, Dora Bigler Wang, Susan A. Leonhardt, Nicholas E. Sherman, Linnia H. Mayeenuddin, John D. Shannon
Publikováno v: Biochemistry. 50:207-220
Characterization of G protein βγ dimer isoform expression in different cellular contexts has been impeded by low levels of protein expression, broad isoform heterogeneity, and antibodies of limited specificity, sensitivity, or availability. As a ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4733b1c8c1c07930d71514f3ac9a95
https://doi.org/10.1021/bi101227y
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