Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Susan A. Krum"'
Autor:
Rachel S. Perkins, Glenn Murray, Sarocha Suthon, Lindsey Davis, Nicholson B. Perkins III, Lily Fletcher, Amanda Bozzi, Saylor L. Schreiber, Jianjian Lin, Steven Laxton, Rahul R. Pillai, Alec J. Wright, Gustavo A. Miranda‐Carboni, Susan A. Krum
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background Treatment for osteosarcoma, a paediatric bone cancer with no therapeutic advances in over three decades, is limited by a lack of targeted therapies. Osteosarcoma frequently metastasises to the lungs, and only 20% of patients survi
Externí odkaz:
https://doaj.org/article/af964c9496044043a9d1aec3c8e55739
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate decisions. WNT10B plays roles in many tissues, including bone, adipocytes, sk
Externí odkaz:
https://doaj.org/article/d9fd31338b9d4b959edb4069d53398d7
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 3, p 38 (2023)
Estrogens, which bind to estrogen receptor alpha (ERα), are important for proper bone mineral density. When women go through menopause, estrogen levels decrease, and there is a decrease in bone quality, along with an increased risk for fractures. We
Externí odkaz:
https://doaj.org/article/bb8c4b1831f149dfaeb89eae33f13b36
Autor:
Sarocha Suthon, Rachel S. Perkins, Vitezslav Bryja, Gustavo A. Miranda-Carboni, Susan A. Krum
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/7f9d4831ffed43158aebaf71d99059ec
Autor:
Sarocha Suthon, Rachel S. Perkins, Vitezslav Bryja, Gustavo A. Miranda-Carboni, Susan A. Krum
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling p
Externí odkaz:
https://doaj.org/article/93d6afbb486245cfa730702a5ba40bfd
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Following genotoxic stress, the histone H2AX becomes phosphorylated at serine 139 by the ATM/ATR family of kinases. The tumor suppressor BRCA1, also phosphorylated by ATM/ATR kinases, is one of several proteins that colocalize with phospho-H2AX (γ-H
Externí odkaz:
https://doaj.org/article/28efe742a788414cb3964d4a92f909a8
Autor:
Sarocha Suthon, Rachel S. Perkins, Jianjian Lin, John R. Crockarell, Gustavo A. Miranda-Carboni, Susan A. Krum
Publikováno v:
Human Genetics. 141:1849-1861
Autor:
Gustavo A. Miranda-Carboni, Susan A. Krum, Victoria Seewaldt, Tiffany N. Seagroves, William E. Lowry, Ruth M. O'Regan, Lily Yang, Lisa D. Yee, Robert Cardiff, Andrew C. White, Raisa I. Krutilina, Hilaire C. Barch, Stephan Lehr, Joseph K. Gray, Wendy Silva, Julio Silva, William L. Kuenzinger, Stephanie Runke, Jackelyn A. Alva-Ornelas, Peter Wend, Iram Fatima, Ikbale El Ayachi
Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfbb347fc17e589e41a0e43ba5161ad7
https://doi.org/10.1158/0008-5472.c.6511163.v1
https://doi.org/10.1158/0008-5472.c.6511163.v1
Autor:
Susan A. Krum, Gustavo A. Miranda-Carboni, Tiffany N. Seagroves, Alexandria V. Slayden, Jerusha Kumpati, Aysha B. Khalid, Iram Fatima, Ikbale El Ayachi, Jesus Garcia-Lopez, Maria Angeles Lillo Osuna
Osteosarcoma is a malignant tumor in the bone, which originates from normal osteoblasts or osteoblast precursors. Normal osteoblasts express estrogen receptor alpha (ERα); however, osteosarcomas do not express ERα due to promoter DNA methylation. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34647a5808ecd8a7f5c59539bfd05419
https://doi.org/10.1158/0008-5472.c.6511551.v1
https://doi.org/10.1158/0008-5472.c.6511551.v1
Autor:
Gustavo A. Miranda-Carboni, Susan A. Krum, Victoria Seewaldt, Tiffany N. Seagroves, William E. Lowry, Ruth M. O'Regan, Lily Yang, Lisa D. Yee, Robert Cardiff, Andrew C. White, Raisa I. Krutilina, Hilaire C. Barch, Stephan Lehr, Joseph K. Gray, Wendy Silva, Julio Silva, William L. Kuenzinger, Stephanie Runke, Jackelyn A. Alva-Ornelas, Peter Wend, Iram Fatima, Ikbale El Ayachi
Supplementary Section: 1) Seven supplementary figures and legends: A. Supplementary figure S1: TCGA analysis of WNT10B network. B. Supplementary figure S2: Human IHC analysis of WNT10B, HMGA2 and EZH2. C. Supplementary figure S3: Mouse IHC analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d588ad2842fb0c7dd56c5ab217cf0a
https://doi.org/10.1158/0008-5472.22422239.v1
https://doi.org/10.1158/0008-5472.22422239.v1