Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Susan A. Jansen‐Varnum"'
Publikováno v:
Journal of Analytical Toxicology. 44:226-236
Indazole carboxamide synthetic cannabinoids remain the most prevalent subclass of new psychoactive substances (NPS) reported internationally. However, the metabolic and pharmacological properties of many of these compounds remain unknown. Elucidating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894e4c11ee8dd84416c840cfe965b470
https://doi.org/10.1093/jat/bkz086
https://doi.org/10.1093/jat/bkz086
Publikováno v:
Biomedical Chromatography. 34
FUB-AMB, an indazole carboxamide synthetic cannabinoid recreational drug, was one of the compounds most frequently reported to governmental agencies worldwide between 2016 and 2019. It has been implicated in intoxications and fatalities, posing a ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa2901158d791f5d38b48fcea79c3f
https://doi.org/10.1002/bmc.4884
https://doi.org/10.1002/bmc.4884
Publikováno v:
Rapid communications in mass spectrometry : RCMREFERENCES. 34(22)
Rationale Indazole carboxamide synthetic cannabinoids, a prevalent class of recreational drugs, are a major clinical, forensic and public health challenge. One such compound, 5F-ADB, has been implicated in fatalities worldwide. Understanding its meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70294f996bf43ab1676702bb5b426272
https://pubmed.ncbi.nlm.nih.gov/32710798
https://pubmed.ncbi.nlm.nih.gov/32710798
Autor:
Bruce Weber, Traciann Dillon, Justin R. Hughey, David Storey, Michael M. Puppolo, Susan A. Jansen‐Varnum, Elizabeth B. Cerkez
Publikováno v:
AAPS Open, Vol 3, Iss 1, Pp 1-13 (2017)
Biorelevant dissolution is an indispensable tool utilized during formulation development and optimization for the prediction of in vivo bioavailability of pharmaceutical agents. Within that framework, membrane-permeation dissolution methodologies are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813f1f12bbdfed78f3d4203cd5231396
http://link.springer.com/article/10.1186/s41120-017-0019-4
http://link.springer.com/article/10.1186/s41120-017-0019-4
Publikováno v:
AAPS PharmSciTech. 18:2841-2853
The presented study describes the development of a membrane permeation non-sink dissolution method that can provide analysis of complete drug speciation and emulate the in vivo performance of poorly water-soluble Biopharmaceutical Classification Syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba96e4b70ea8d54913d85b37cd7bb0a
https://doi.org/10.1208/s12249-017-0783-4
https://doi.org/10.1208/s12249-017-0783-4
Publikováno v:
Biomedical chromatography : BMCREFERENCES. 34(3)
Studies of the metabolic and pharmacological profiles of indole carboxamide synthetic cannabinoids (a prevalent class of new psychoactive substances) are critical in ensuring that their use can be detected through bioanalytical testing. We have deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c379ff2ceb280583878b510df46837
https://pubmed.ncbi.nlm.nih.gov/31863591
https://pubmed.ncbi.nlm.nih.gov/31863591
Publikováno v:
Drug testing and analysis. 11(8)
Synthetic cannabinoids have proliferated over the last decade and have become a major public health and analytical challenge, critically impacting the clinical and forensic communities. Indazole carboxamide class synthetic cannabinoids have been part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ef91b2de41a52c3313de26effd1c9c
https://pubmed.ncbi.nlm.nih.gov/31108568
https://pubmed.ncbi.nlm.nih.gov/31108568
Autor:
Michael M. Puppolo, Justin R. Hughey, Zachary N. Warnken, Iris Duarte, Susan A. Jansen‐Varnum
Publikováno v:
Journal of pharmaceutical sciences. 107(1)
During formulation development, efficiently integrating in vitro dissolution testing can significantly improve one's ability to estimate in vivo performance and aide in the selection of premier drug candidates. The concept of in vitro-in vivo relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26c14c3aee60fd1a747240490701252
https://pubmed.ncbi.nlm.nih.gov/29045883
https://pubmed.ncbi.nlm.nih.gov/29045883
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. :6-17
In this research, electron paramagnetic resonance (EPR) spin-trapping was utilized to determine if surface radical chemistries occur for gamma (γ)-sterilized orthopedic materials—ultra-high molecular weight polyethylene (UHMWPE) and the novel, hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b609e771b0874fbf179c6b41bd834134
https://doi.org/10.1002/jbm.b.30164
https://doi.org/10.1002/jbm.b.30164