Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Susan A. Harcourt"'
Autor:
Jillian E. Lowe, Susan A. Harcourt, Colin F. Arlett, Adam J Marcovitch, Michael H.L. Green, Irene C. Green
Publikováno v:
Free Radical Biology and Medicine. 22:343-347
Ataxia-telangiectasia (A-T) is a human autosomal recessive disease characterised by immunodeficiency, extreme sensitivity to ionising radiation and progressive cerebellar ataxia. The defective gene has recently been cloned and is a member of the phos
Autor:
Peter H. Clingen, Colin F. Arlett, Susan A. Harcourt, Jane Cole, Michael H.L. Green, Alastair P.W. Waugh, Jillian E. Lowe
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 350:239-246
Non-cycling human T-lymphocytes from normal subjects show a 10-fold greater sensitivity than fibroblasts to UV-B (280-315 nm) irradiation from a Westinghouse FS20 lamp, but only a 2.7-fold greater sensitivity to UV-C (254 nm) irradiation. Hypersensit
Autor:
Colin F. Arlett, Alastair P.W. Waugh, Michael H.L. Green, Jillian E. Lowe, Susan A. Harcourt, Jane Cole
Publikováno v:
Mutation Research/DNA Repair. 315:25-32
We have previously shown that non-cycling (unstimulated) human lymphocytes from normal donors show extreme hypersensitivity to UV-B irradiation, and are killed by an excisable lesion which is not a pyrimidine dimer or 6-4 photoproduct. In this paper
Autor:
Colin F. Arlett, Bernard C. Broughton, Alain Sarasin, W.J. Keijer, Susan A. Harcourt, F.A. Beemer, D.L. Mitchell, R. Nairn, Alan R. Lehmann
Publikováno v:
Mutation Research/DNA Repair. 235:33-40
Trichothiodystrophy is a genetic disease which in the majority of cases studied is associated with a deficiency in the ability to repair UV damage in cellular DNA. Three categories of UV response have been identified. In type 1 the response is comple
Autor:
Bernard C. Broughton, Alain Sarasin, Miria Stefanini, Nicolaas G. J. Jaspers, Elena Botta, Elaine M. Taylor, Colin F. Arlett, Alan R. Lehmann, Susan A. Harcourt, Heather Fawcett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(16)
The xeroderma pigmentosum group D (XPD) protein has a dual function, both in nucleotide excision repair of DNA damage and in basal transcription. Mutations in the XPD gene can result in three distinct clinical phenotypes, XP, trichothiodystrophy (TTD
Autor:
Susan A. Harcourt, T. Rowe, Jillian E. Lowe, Jane Cole, Colin F. Arlett, Michael H.L. Green, Alexander Vincent Anstey, P. Akinluyi
Publikováno v:
Mutation research. 273(2)
We have studied incision-break formation in unstimulated and stimulated populations of human T-lymphocytes using the comet (single-cell microgel electrophoresis) assay. The frequency of strand breaks 1 h after UV-irradiation appears to be far greater
Publikováno v:
Mutation research. 273(2)
Unstimulated T-lymphocytes from normal donors are significantly more sensitive to the lethal effects of UV-C than either stimulated T-lymphocytes or fibroblasts as judged by colony-forming ability. Data from other studies suggest that excision repair
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 33:261-277
The forward mutation selection system based on resistance to 8-azaguanine has been widely used with cells cultured from a diversity of species and with a variety of mutagens. Ouabain resistance is an alternative selective system. Both systems show a
Autor:
Alan R. Lehmann, M.A. Ferguson-Smith, Susan A. Harcourt, W.N. Morley, Colin F. Arlett, S. Stevens
Publikováno v:
Carcinogenesis. 1:745-751
XP3BR is a fibroblast strain derived from a xeroderma pigmentosum patient exhibiting severe mental retardation in addition to the typical changes in the skin. No tumours have been observed by 6 years of age. Cells from this patient had no detectable
Autor:
Susan A. Harcourt, C. Drevon, M.M. Gebara, Julian F. Burke, H. Steingrimsdottir, Alan R. Lehmann, C F Arlett, M R James
Publikováno v:
Molecular and Cellular Biology. 7:1459-1464
Plasmids containing the bacterial gpt gene under control of the simian virus 40 promoter were transfected into a simian virus 40-transformed human fibroblast line. Two transfectants, E2 and C10, which contain stably integrated single copies of the gp