Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Susan A. Gilbert"'
Publikováno v:
Molecular biology of the cell. 33(13)
Propofol is a widely used general anesthetic, yet the understanding of its cellular effects is fragmentary. General anesthetics are not as innocuous as once believed and have a wide range of molecular targets that include kinesin motors. Propofol, ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70455ff635ff6b56fe1ce15327c87f0
https://pubmed.ncbi.nlm.nih.gov/36103253
https://pubmed.ncbi.nlm.nih.gov/36103253
Kinesin-driven organelle transport is crucial for neuron development and maintenance, yet the mechanisms by which kinesins specifically bind their organelle cargoes remain undefined. In contrast to other transport kinesins, the neuronal function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb95bacf9ba44bd5b051a056faeb8a25
https://doi.org/10.1101/2022.07.30.502069
https://doi.org/10.1101/2022.07.30.502069
Publikováno v:
J Biol Chem
Heterodimeric kinesin family member KIF3AC is a mammalian kinesin-2 that is highly expressed in the central nervous system and has been implicated in intracellular transport. KIF3AC is unusual in that the motility characteristics of KIF3C when expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411e831a7cd8537f6519c89f8d472c04
https://doi.org/10.1074/jbc.ra119.010725
https://doi.org/10.1074/jbc.ra119.010725
Publikováno v:
Proc Natl Acad Sci U S A
Propofol is a widely used general anesthetic to induce and maintain anesthesia, and its effects are thought to occur through impact on the ligand-gated channels including the GABA(A) receptor. Propofol also interacts with a large number of proteins i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64faf0c8ca3009b0654a1c202069c8e5
https://doi.org/10.1073/pnas.2023659118
https://doi.org/10.1073/pnas.2023659118
Publikováno v:
PLoS ONE, Vol 8, Iss 2 (2013)
[This corrects the article DOI: 10.1371/journal.pone.0053792.].
Externí odkaz:
https://doaj.org/article/57d486b746f14211b78648ef7801299f
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53792 (2013)
We have used cryo-electron microscopy (cryo-EM) and helical averaging to examine the 3-D structure of the heterodimeric kinesin-14 Kar3Vik1 complexed to microtubules at a resolution of 2.5 nm. 3-D maps were obtained at key points in Kar3Vik1's nucleo
Externí odkaz:
https://doaj.org/article/2c7e6027515a478aaeb26990f9182708
Publikováno v:
The Journal of Biological Chemistry
Heterodimeric KIF3AC is a mammalian kinesin-2 that is highly expressed in the central nervous system and associated with vesicles in neurons. KIF3AC is an intriguing member of the kinesin-2 family because the intrinsic kinetics of KIF3A and KIF3C whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a791803a832d69e7a77c217fa0e07c7b
https://pubmed.ncbi.nlm.nih.gov/33144324
https://pubmed.ncbi.nlm.nih.gov/33144324
Publikováno v:
Journal of Biological Chemistry. 293:13389-13400
Heterodimeric KIF3AC and KIF3AB, two members of the mammalian kinesin-2 family, generate force for microtubule plus end–directed cargo transport. However, the advantage of heterodimeric kinesins over homodimeric ones is not well-understood. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566adfb2c1bff1f95071c6de3aedf3d6
https://doi.org/10.1074/jbc.ra118.002767
https://doi.org/10.1074/jbc.ra118.002767
Autor:
Roderic G. Eckenhoff, Susan P. Gilbert, William P. Dailey, Kellie A. Woll, Brandon M. Bensel, Benjamin A. Garcia, Stephanie Guzik-Lendrum, Natarajan V. Bhanu
Publikováno v:
The Journal of Biological Chemistry
Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531466032d3dc18c234e942ba3900fc0
https://doi.org/10.1074/jbc.ra118.002182
https://doi.org/10.1074/jbc.ra118.002182