Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Susan A. Gauthier"'
Autor:
Nara M. Michaelson, Sandra H. Rúa, Ulrike W. Kaunzner, Melanie Marcille, Iliana Pliska‐Bloch, Kimberly Markowitz, Thanh D. Nguyen, Susan A. Gauthier
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 2923-2931 (2024)
Abstract Objective Black American (BA) multiple sclerosis (MS) patients experience greater disability compared to White American (WA) patients. Here, we investigated the role of paramagnetic rim lesions (PRLs), a subset of chronic active lesions, on
Externí odkaz:
https://doaj.org/article/43b9e1773ba447b7b4b804ca541367ce
Publikováno v:
Network Neuroscience, Vol 7, Iss 2, Pp 539-556 (2023)
AbstractQuantifying the relationship between the brain’s functional activity patterns and its structural backbone is crucial when relating the severity of brain pathology to disability in multiple sclerosis (MS). Network control theory (NCT) charac
Externí odkaz:
https://doaj.org/article/3fd27fde673d491fa06d44817a62fffe
Autor:
Liangdong Zhou, Yi Li, Elizabeth M. Sweeney, Xiuyuan H. Wang, Amy Kuceyeski, Gloria C. Chiang, Jana Ivanidze, Yi Wang, Susan A. Gauthier, Mony J. de Leon, Thanh D. Nguyen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Background and purposeOur objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20–80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.
Externí odkaz:
https://doaj.org/article/0bb2151f3dfb410aad3fcac1a34e9636
Autor:
Alexey V. Dimov, Kelly M. Gillen, Thanh D. Nguyen, Jerry Kang, Ria Sharma, David Pitt, Susan A. Gauthier, Yi Wang
Publikováno v:
Tomography, Vol 8, Iss 3, Pp 1544-1551 (2022)
Quantitative susceptibility mapping (QSM) facilitates mapping of the bulk magnetic susceptibility of tissue from the phase of complex gradient echo (GRE) MRI data. QSM phase processing combined with an R2* model of magnitude of multiecho gradient ech
Externí odkaz:
https://doaj.org/article/0359815c549741a298f364f29f2740f2
Autor:
Yinghua Ma, David Sannino, Jennifer R. Linden, Sylvia Haigh, Baohua Zhao, John B. Grigg, Paul Zumbo, Friederike Dündar, Daniel Butler, Caterina P. Profaci, Kiel Telesford, Paige N. Winokur, Kareem R. Rumah, Susan A. Gauthier, Vincent A. Fischetti, Bruce A. McClane, Francisco A. Uzal, Lily Zexter, Michael Mazzucco, Richard Rudick, David Danko, Evan Balmuth, Nancy Nealon, Jai Perumal, Ulrike Kaunzner, Ilana L. Brito, Zhengming Chen, Jenny Z. Xiang, Doron Betel, Richard Daneman, Gregory F. Sonnenberg, Christopher E. Mason, Timothy Vartanian
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR dete
Externí odkaz:
https://doaj.org/article/f0c0efe29a314b36bf138e14c6f076be
Autor:
Melanie Marcille, Sandra Hurtado Rúa, Charles Tyshkov, Abhishek Jaywant, Joseph Comunale, Ulrike W. Kaunzner, Nancy Nealon, Jai S. Perumal, Lily Zexter, Nicole Zinger, Olivia Bruvik, Yi Wang, Elizabeth Sweeney, Amy Kuceyeski, Thanh D. Nguyen, Susan A. Gauthier
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Quantitative susceptibility mapping (QSM), an imaging technique sensitive to brain iron, has been used to detect paramagnetic rims of iron-laden active microglia and macrophages in a subset of multiple sclerosis (MS) lesions, known as rim+ l
Externí odkaz:
https://doaj.org/article/4ef6e94e55394aebb8a3b3f194aec9b7
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/70de704e606e49e9bb4b4b4cb657e392
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1755-1759 (2021)
Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparis
Externí odkaz:
https://doaj.org/article/f6d5c88a07614bbea10c13a0ed3a23be
Autor:
Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich, Sadek A. Nehmeh
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-17 (2021)
Abstract Introduction Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to assess the reproducib
Externí odkaz:
https://doaj.org/article/0abed0fc7ec04f42889330944c1c9a00
Autor:
Kelly M. Gillen, Mayyan Mubarak, Calvin Park, Gerald Ponath, Shun Zhang, Alexey Dimov, Maya Levine‐Ritterman, Steven Toro, Weiyuan Huang, Stephanie Amici, Ulrike W. Kaunzner, Susan A. Gauthier, Mireia Guerau‐de‐Arellano, Yi Wang, Thanh D. Nguyen, David Pitt
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 4, Pp 877-886 (2021)
Abstract Background Inflammation in chronic active lesions occurs behind a closed blood–brain barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron and can be visualized with quantitative susceptibility mapping (
Externí odkaz:
https://doaj.org/article/6e26628159d547dba32563ac9fe2dc94