Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Susan A. Farr"'
Autor:
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We invest
Externí odkaz:
https://doaj.org/article/5b44d6910ee840eebed105fd78d879a2
Autor:
Denise M. Smith, Michael L. Niehoff, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Susan A. Farr, Miles F. Wilkinson, Andrew D. Nguyen
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a means to incr
Externí odkaz:
https://doaj.org/article/82651a85b9bf4f0082f04f8ac4b72d06
Autor:
Silvia Squillace, Michael L. Niehoff, Timothy M. Doyle, Michael Green, Emanuela Esposito, Salvatore Cuzzocrea, Christopher K. Arnatt, Sarah Spiegel, Susan A. Farr, Daniela Salvemini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are no FDA-approved interventions. Sphingolipidomic analysis of mouse prefronta
Externí odkaz:
https://doaj.org/article/1997f1a57945403ea08d3af60277e069
Autor:
Subhashis Banerjee, Sarbani Ghoshal, Clemence Girardet, Kelly M. DeMars, Changjun Yang, Michael L. Niehoff, Andrew D. Nguyen, Prerana Jayanth, Brittany A. Hoelscher, Fenglian Xu, William A. Banks, Kim M. Hansen, Jinsong Zhang, Eduardo Candelario-Jalil, Susan A. Farr, Andrew A. Butler
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enrich
Externí odkaz:
https://doaj.org/article/76f1c0c442654891acc905cc4c82ecdb
Autor:
Susan A. Farr, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo, Michael L. Niehoff, Timothy M. Doyle, Daniela Salvemini
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Traumatic brain injury (TBI) is a common pathological condition that presently lacks a specific pharmacological treatment. Adenosine levels rise following TBI, which is thought to be neuroprotective against secondary brain injury.
Externí odkaz:
https://doaj.org/article/0af6ca2da5904eb890fffdc4fb84dcce
Autor:
Changjun Yang, Bianca P. Lavayen, Lei Liu, Brian D. Sanz, Kelly M. DeMars, Jonathan Larochelle, Marjory Pompilus, Marcelo Febo, Yu-Yo Sun, Yi-Min Kuo, Mansour Mohamadzadeh, Susan A. Farr, Chia-Yi Kuan, Andrew A. Butler, Eduardo Candelario-Jalil
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102197- (2021)
Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier function. Blood-brain barrier (BBB) disruption is a key pathological event in cerebral ischemia. However, the effects of adropin on ischemic stroke outcomes rem
Externí odkaz:
https://doaj.org/article/d7c0488233404b359c5b732943c3ea34
Autor:
Michelle A. Erickson, Aric F. Logsdon, Elizabeth M. Rhea, Kim M. Hansen, Sarah J Holden, William A Banks, Jessica L. Smith, Cody German, Susan A. Farr, John E. Morley, Riley R Weaver, Alec J. Hirsch, Andrej Kovac, Eva Kontsekova, Kristen K. Baumann, Mohamed A. Omer, Jacob Raber
Publikováno v:
Brain, Behavior, and Immunity. 109:251-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ad2cb2fd41cc47830a164dcc3a6b20
https://doi.org/10.1016/j.bbi.2023.01.010
https://doi.org/10.1016/j.bbi.2023.01.010
Autor:
Denise M. Smith, Geetika Aggarwal, Michael L. Niehoff, Spencer A. Jones, Subhashis Banerjee, Susan A. Farr, Andrew D. Nguyen
Publikováno v:
bioRxiv
Heterozygous loss-of-function mutations in the progranulin gene (GRN) are a major cause of frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of progranulin causes neuronal ceroid lipofuscinosis. Several progranulin-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfec5b7423d3e8855ea2cc331447150
https://doi.org/10.1101/2023.05.27.542495
https://doi.org/10.1101/2023.05.27.542495
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5732bebc2fdd01e58f5eb312c33626a
https://doi.org/10.1124/jpet.122.539230
https://doi.org/10.1124/jpet.122.539230
Autor:
Ariel Magee, Susan A. Farr, Mike Niehoff, Ivonne Larrea, Yoan Ganev, Ken Witt, Justin Samanta
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d75265158f3b095f436552cd1523652
https://doi.org/10.1124/jpet.122.525880
https://doi.org/10.1124/jpet.122.525880