Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Susan A, Shinton"'
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-24 (2024)
Abstract Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is the negative from neonate to ol
Externí odkaz:
https://doaj.org/article/3b06c95213b64ece96f8c6493fa9c072
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Newborns require early generation of effective innate immunity as a primary physiological mechanism for survival. The neonatal Lin28+Let7– developmental pathway allows increased generation of Th2-type cells and B1a (B-1 B) cells compared t
Externí odkaz:
https://doaj.org/article/5e33a377904d40abab796cb9364fd37a
Autor:
Kyoko Hayakawa, Yue-Sheng Li, Susan A. Shinton, Srinivasa R. Bandi, Anthony M. Formica, Joni Brill-Dashoff, Richard R. Hardy
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The Lin28b+Let7− axis in fetal/neonatal development plays a role in promoting CD5+ B1a cell generation as a B-1 B cell developmental outcome. Here we identify the Let7 target, Arid3a, as a crucial molecular effector of the B-1 cell developmental pr
Externí odkaz:
https://doaj.org/article/76d33718fd0f4951baf0a943410ae250
Autor:
Warren D. Kruger, Richard R. Hardy, Craig H. Bassing, Tahseen I. Al-Saleem, Andres Klein-Szanto, Xiang Hua, Eoin P. Quinlivan, Susan A. Shinton, Baiqing Tang, Bu Yin, Yuwaraj Kadariya
Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF, and MTAP are common in a wide variety of human cancers. The role for CDKN2A and ARF in tumorigenesis is well established, but whether MTAP loss directly affects tumorigenesis is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdb8d8d5a4b132ee3b3941708b77c1b
https://doi.org/10.1158/0008-5472.c.6499089.v1
https://doi.org/10.1158/0008-5472.c.6499089.v1
Autor:
Warren D. Kruger, Richard R. Hardy, Craig H. Bassing, Tahseen I. Al-Saleem, Andres Klein-Szanto, Xiang Hua, Eoin P. Quinlivan, Susan A. Shinton, Baiqing Tang, Bu Yin, Yuwaraj Kadariya
Supplementary Figures 1-3, Table 1 from Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461ac7c468f7bc3e99d081202235a061
https://doi.org/10.1158/0008-5472.22379007.v1
https://doi.org/10.1158/0008-5472.22379007.v1
Autor:
Warren D. Kruger, Richard R. Hardy, Craig H. Bassing, Tahseen I. Al-Saleem, Andres Klein-Szanto, Xiang Hua, Eoin P. Quinlivan, Susan A. Shinton, Baiqing Tang, Bu Yin, Yuwaraj Kadariya
Supplementary Figure Legends 1-3 from Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023524c49ff10da14516269bf19d233d
https://doi.org/10.1158/0008-5472.22379010
https://doi.org/10.1158/0008-5472.22379010
Autor:
Christoph Seiler, Nichole Gebhart, Yong Zhang, Susan A Shinton, Yue-sheng Li, Nicola L Ross, Xingjun Liu, Qin Li, Alison N Bilbee, Gaurav K Varshney, Matthew C LaFave, Shawn M Burgess, Jorune Balciuniene, Darius Balciunas, Richard R Hardy, Dietmar J Kappes, David L Wiest, Jennifer Rhodes
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131908 (2015)
Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability of zebrafish make this a powerful model
Externí odkaz:
https://doaj.org/article/1f7bec41e2a44af78a4f88d4a9b2264a
Autor:
Yuka Nakao, Daiju Ichikawa, Susan A. Shinton, Joni Brill-Dashoff, Herbert C. Morse, Mitchell R. Smith, Kyoko Hayakawa, Richard R. Hardy, Anthony M. Formica
Publikováno v:
The Journal of Immunology. 201:804-813
In mice, fetal/neonatal B-1 cell development generates murine CD5+ B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a VH11/D/JH knock-in mouse line (VH11t) that generates an autoreactive antiphosphatidylcholine BCR. O
Autor:
Lina E Tze, Brian R Schram, Kong-Peng Lam, Kristin A Hogquist, Keli L Hippen, Jiabin Liu, Susan A Shinton, Kevin L Otipoby, Peter R Rodine, Amanda L Vegoe, Manfred Kraus, Richard R Hardy, Mark S Schlissel, Klaus Rajewsky, Timothy W Behrens
Publikováno v:
PLoS Biology, Vol 3, Iss 3, p e82 (2005)
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearran
Externí odkaz:
https://doaj.org/article/fb872538aa824b9d9c88f9a8f5d24eae
Autor:
Hui Feng, Kyoko Hayakawa, Jennifer Rhodes, Yue-Sheng Li, Cicely A. Jette, Richard R. Hardy, A. Thomas Look, Lingjuan Tang, Susan A. Shinton, Xingjun Liu
Publikováno v:
The Journal of Immunology. 199:1706-1715
CD79a and CD79b proteins associate with Ig receptors as integral signaling components of the B cell Ag receptor complex. To study B cell development in zebrafish, we isolated orthologs of these genes and performed in situ hybridization, finding that