Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Susan, Wyllie"'
Autor:
Richard J. Wall, Stuart A. MacGowan, Irene Hallyburton, Aisha J. Syed, Sowmya Ajay Castro, Gourav Dey, Rachel Milne, Stephen Patterson, Jody Phelan, Natalie Wiedemar, Susan Wyllie
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT New and improved drugs are required for the treatment and ultimate eradication of malaria. The efficacy of front-line therapies is now threatened by emerging drug resistance; thus, new tools to support the development of drugs with a lower p
Externí odkaz:
https://doaj.org/article/33debac63a434d15a1b26f35732aa229
Autor:
Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice Vanelle, Pierre Verhaeghe, Nadine Azas, Hussein El-Kashef
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 878 (2024)
A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2–5 steps and their structure was proved by elemental and spectral analyses. The compounds obtained were evaluated in vitro against the promastigote stag
Externí odkaz:
https://doaj.org/article/19bbdde0254342f6abec98d71ef49a9d
Autor:
Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTVisceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. New therapeutic options with diverse mechanisms of actions (MoAs) are required to consolidate progress toward control o
Externí odkaz:
https://doaj.org/article/7bb16e5a50ee43d6b0b2d50b417e7077
Autor:
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
Externí odkaz:
https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3
Autor:
Jack C. Hanna, Victor Corpas-Lopez, Simona Seizova, Beatrice L. Colon, Ross Bacchetti, Grant M. J. Hall, Emma M. Sands, Lee Robinson, Beatriz Baragaña, Susan Wyllie, Mattie C. Pawlowic
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionCryptosporidiosis is a leading cause of diarrheal-associated morbidity and mortality, predominantly affecting children under 5 years old in low-and-middle-income countries. There is no effective treatment and no vaccine. New therapeutics
Externí odkaz:
https://doaj.org/article/d00f990a5eec45dd880bc3d721f16c09
Autor:
Alan H. Fairlamb, Susan Wyllie
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Understanding the target and mode of action of compounds identified by phenotypic screening can greatly facilitate the process of drug discovery and development. Here, we outline the tools currently available for target identification against the neg
Externí odkaz:
https://doaj.org/article/5a288c7e95f44b9d9ad4dea0750935ad
Autor:
Robert J. Smith, Rachel Milne, Victoriano Corpas Lopez, Natalie Wiedemar, Gourav Dey, Aisha J. Syed, Stephen Patterson, Susan Wyllie
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102002- (2023)
Summary: Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor selectively binds its molec
Externí odkaz:
https://doaj.org/article/1a30dcc35b09405bb943795be1123f19
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009870 (2021)
Chagas disease, caused by the protozoan intracellular parasite Trypanosoma cruzi, is a highly neglected tropical disease, causing significant morbidity and mortality in central and south America. Current treatments are inadequate, and recent clinical
Externí odkaz:
https://doaj.org/article/0428e734a42f4d65a9fe295ff74ee419
Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds
Autor:
Victoriano Corpas-Lopez, Susan Wyllie
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100704- (2021)
Summary: Here, we detail our optimized protocol for the identification of drug targets in Leishmania donovani using thermal proteome profiling. This approach is based on the principle that binding of a drug to its protein target can significantly alt
Externí odkaz:
https://doaj.org/article/660ce2ad6d5c4a44bec308460a5943d7
Autor:
Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille, Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain, Charles E. Mowbray, Stéphanie Braillard, Marc Ouellette, Louis Maes, Guy Caljon
Publikováno v:
Microorganisms, Vol 9, Iss 7, p 1408 (2021)
Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases initiative (DNDi) has invested in the devel
Externí odkaz:
https://doaj.org/article/3fffc5e0d8f34c3a82d0f26fc93ce6de