Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Susan, Wong"'
Autor:
Marie-Andrée Bessard, Anna Moser, Emmanuelle Waeckel-Énée, Vivian Lindo, Abdelaziz Gdoura, Sylvaine You, F. Susan Wong, Fiona Greer, Peter van Endert
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive T cells. As an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune CD4+ and CD8+ T cell responses and islet infla
Externí odkaz:
https://doaj.org/article/4493069f3b8a4b9f9080e9bef49ca1c2
Autor:
Dimitri Kakabadse, Dawei Chen, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Li Wen, Gideon Gross, F. Susan Wong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionIn this study, we report a novel therapeutic approach redirecting antigen-specific CD4+ T cells recognizing a hybrid insulin peptide (BDC2.5 T cell receptor (TCR) transgenic CD4+ T cells) to attract and suppress islet-specific CD8+ T cell
Externí odkaz:
https://doaj.org/article/761b56308e79419ba5d4331c899df090
Autor:
Pai Wang, Xin Yang, Luyao Zhang, Sha Sha, Juan Huang, Jian Peng, Jianlei Gu, James Alexander Pearson, Youjia Hu, Hongyu Zhao, F. Susan Wong, Quan Wang, Li Wen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell-specific Tlr9-deficient (Tlr9 f
Externí odkaz:
https://doaj.org/article/ddc6b00a11fc457385775e297ca7f58c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionType 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β cells. Toll-like receptor 9 (TLR9) plays a role in autoimmune diseases, and B cell-specific TLR9 deficiency delays T1D development. Gu
Externí odkaz:
https://doaj.org/article/f97aaf7bed1945148034411f934ca7da
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
There has been a major increase in Type 2 diabetes and obesity in many countries, and this will lead to a global public health crisis, which not only impacts on the quality of life of individuals well but also places a substantial burden on healthcar
Externí odkaz:
https://doaj.org/article/0097d2b6a0f74de4a0cafb3dd3799503
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe incidence of the autoimmune disease, type 1 diabetes (T1D), has been increasing worldwide and recent studies have shown that the gut microbiota are associated with modulating susceptibility to T1D. Toll-like receptor 5 (TLR5) recogniz
Externí odkaz:
https://doaj.org/article/f49d25e268f04923a01b31f47da686c0
Autor:
Stephanie J. Hanna, Terri C. Thayer, Emma J. S. Robinson, Ngoc-Nga Vinh, Nigel Williams, Laurie G. Landry, Robert Andrews, Qi Zhuang Siah, Pia Leete, Rebecca Wyatt, Martina A. McAteer, Maki Nakayama, F. Susan Wong, Jennie H. M. Yang, Timothy I. M. Tree, Johnny Ludvigsson, Colin M. Dayan, Danijela Tatovic
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in p
Externí odkaz:
https://doaj.org/article/53e6f7919fde4d98856728343312e345
Autor:
Dawei Chen, Dimitri Kakabadse, Sigal Fishman, Hadas Weinstein-Marom, Joanne Davies, Joanne Boldison, Terri C. Thayer, Li Wen, Gideon Gross, F. Susan Wong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIn this study, we report a novel therapeutic approach using B lymphocytes to attract islet-specific T cells in the non-obese diabetic (NOD) mouse model and prevent the development of autoimmune diabetes. Rather than using the antibody rec
Externí odkaz:
https://doaj.org/article/fbacf4f7fe164db5bbdbb5bcacd5797c
Autor:
James A. Pearson, Jian Peng, Juan Huang, Xiaoqing Yu, Ningwen Tai, Youjia Hu, Sha Sha, Richard A. Flavell, Hongyu Zhao, F. Susan Wong, Li Wen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionGut microbiota have been linked to modulating susceptibility to Type 1 diabetes; however, there are many ways in which the microbiota interact with host cells, including through microbial ligand binding to intracellular inflammasomes (lar
Externí odkaz:
https://doaj.org/article/e81605a24c0f43b481c0a75c772edb75
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Type 2 diabetes mellitus, obesity and metabolic syndrome are becoming more prevalent worldwide and will present an increasingly challenging burden on healthcare systems. These interlinked metabolic abnormalities predispose affected individuals to a p
Externí odkaz:
https://doaj.org/article/ae4fd85be4244628a6dbe6afec0fa509