Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Susan, Walsh"'
Autor:
Michiel Vanneste, Hanne Hoskens, Seppe Goovaerts, Harold Matthews, Jay Devine, Jose D. Aponte, Joanne Cole, Mark Shriver, Mary L. Marazita, Seth M. Weinberg, Susan Walsh, Stephen Richmond, Ophir D. Klein, Richard A. Spritz, Hilde Peeters, Benedikt Hallgrímsson, Peter Claes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectru
Externí odkaz:
https://doaj.org/article/53249a4e52054d56af916527ff5bdc39
Autor:
Sharika Bamezai, Yapei Zhang, Manisha Kumari, Mozhgan Lotfi, Tom Alsaigh, Lingfeng Luo, Gayatri Suresh Kumar, Fudi Wang, Jianqin Ye, Madhu Puri, Romila Manchanda, Sesha Paluri, Shaunak S. Adkar, Yoko Kojima, Alice Ingelsson, Caitlin F. Bell, Nicolas G. Lopez, Changhao Fu, Ryan B. Choi, Zach Miller, Leo Barrios, Susan Walsh, Ferhaan Ahmad, Lars Maegdefessel, Bryan Ronain Smith, Nicholas J. Leeper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal of cells by macrophages, has emerged as a translational target for atherosclerosis. Systemic blockade o
Externí odkaz:
https://doaj.org/article/ed48ff63aa9a4c0ea91f4e3d3668de0d
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Automatic dense 3D surface registration is a powerful technique for comprehensive 3D shape analysis that has found a successful application in human craniofacial morphology research, particularly within the mandibular and cranial vault regio
Externí odkaz:
https://doaj.org/article/973b8a5e1763463ba523425d13f8f72d
Autor:
Noah Herrick, Susan Walsh
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Processing raw genomic data for downstream applications such as imputation, association studies, and modeling requires numerous third-party bioinformatics software tools. It is highly time-consuming and resource-intensive with com
Externí odkaz:
https://doaj.org/article/af6a4e1476424a919b01a9d3252f7fc3
Autor:
Seppe Goovaerts, Hanne Hoskens, Ryan J. Eller, Noah Herrick, Anthony M. Musolf, Cristina M. Justice, Meng Yuan, Sahin Naqvi, Myoung Keun Lee, Dirk Vandermeulen, Heather L. Szabo-Rogers, Paul A. Romitti, Simeon A. Boyadjiev, Mary L. Marazita, John R. Shaffer, Mark D. Shriver, Joanna Wysocka, Susan Walsh, Seth M. Weinberg, Peter Claes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The cranial vault in humans is highly variable, clinically relevant, and heritable, yet its genetic architecture remains poorly understood. Here, we conduct a joint multi-ancestry and admixed multivariate genome-wide association study on 3D
Externí odkaz:
https://doaj.org/article/69a3d3cc3f27415f9870d75eead756a6
Autor:
Jaaved Mohammed, Neha Arora, Harold S Matthews, Karissa Hansen, Maram Bader, Susan Walsh, John R Shaffer, Seth M Weinberg, Tomek Swigut, Peter Claes, Licia Selleri, Joanna Wysocka
Publikováno v:
eLife, Vol 13 (2024)
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certain cases, si
Externí odkaz:
https://doaj.org/article/2cc1a2d4cf454d649f23f3d5f8c28b50
Autor:
Zuqi Li, Federico Melograna, Hanne Hoskens, Diane Duroux, Mary L. Marazita, Susan Walsh, Seth M. Weinberg, Mark D. Shriver, Bertram Müller-Myhsok, Peter Claes, Kristel Van Steen
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Multi-view data offer advantages over single-view data for characterizing individuals, which is crucial in precision medicine toward personalized prevention, diagnosis, or treatment follow-up.Methods: Here, we develop a network-guided m
Externí odkaz:
https://doaj.org/article/01f1dc8fd9614fd58c2406d60526e091
Autor:
Franziska Wilke, Noah Herrick, Harold Matthews, Hanne Hoskens, Sylvia Singh, John R. Shaffer, Seth M. Weinberg, Mark D. Shriver, Peter Claes, Susan Walsh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Facial ancestry can be described as variation that exists in facial features that are shared amongst members of a population due to environmental and genetic effects. Even within Europe, faces vary among subregions and may lead to confoundin
Externí odkaz:
https://doaj.org/article/563b8273693847c8a42465d2fc1667be
Autor:
Meng Yuan, Hanne Hoskens, Seppe Goovaerts, Noah Herrick, Mark D. Shriver, Susan Walsh, Peter Claes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Analysis of population structure and genomic ancestry remains an important topic in human genetics and bioinformatics. Commonly used methods require high-quality genotype data to ensure accurate inference. However, in practice, laboratory ar
Externí odkaz:
https://doaj.org/article/b9c606ff521942aab5d096ec6cd8f4b5
Autor:
Susan Walsh
In a compelling first-hand account of development assistance gone awry, Susan Walsh recounts how national, international, and multilateral organizations failed the Jalq'a people in the Bolivian Andes during the early millennium. Intent on assisting p
