Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Susan, Tzotzos"'
Autor:
Pau Martin-Malpartida, Silvia Arrastia-Casado, Josep Farrera-Sinfreu, Rudolf Lucas, Hendrik Fischer, Bernhard Fischer, Douglas C. Eaton, Susan Tzotzos, Maria J. Macias
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2082-2090 (2022)
Tumor necrosis factor (TNF) is a homotrimer that has two spatially distinct binding regions, three lectin-like domains (LLD) at the TIP of the protein and three basolaterally located receptor-binding sites, the latter of which are responsible for the
Externí odkaz:
https://doaj.org/article/ea4fe0d30ea4492692d732f254ef1316
Autor:
Rosa Lemmens-Gruber, Susan Tzotzos
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7775 (2023)
Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical pathways and as such are involved in several disease states. Dependent on site and type of mutation, gain- or loss-of-function generated symptoms occur which s
Externí odkaz:
https://doaj.org/article/fa76af76f3bc4955870be0109ba2e369
Autor:
Anita Willam, Mohammed Aufy, Susan Tzotzos, Dina El-Malazi, Franziska Poser, Alina Wagner, Birgit Unterköfler, Didja Gurmani, David Martan, Shahid Muhammad Iqbal, Bernhard Fischer, Hendrik Fischer, Helmut Pietschmann, Istvan Czikora, Rudolf Lucas, Rosa Lemmens-Gruber, Waheed Shabbir
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Previous in vitro studies have indicated that tumor necrosis factor (TNF) activates amiloride-sensitive epithelial sodium channel (ENaC) current through its lectin-like (TIP) domain, since cyclic peptides mimicking the TIP domain (e.g., solnatide), s
Externí odkaz:
https://doaj.org/article/4ccbfa0917da48fc8e905dbc10f7b2cb
Autor:
Susan Tzotzos
Publikováno v:
Journal of Peptide Science. 28
Stapled peptides are synthetic peptidomimetics of bioactive sites in folded proteins which carry chemical links, introduced during peptide synthesis, designed to retain the secondary structure in the native protein molecule. Stapled peptides have bee
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-4 (2020)
Critical Care
Critical Care
Research letter: Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey
Autor:
Rudolf Lucas, Douglas C. Eaton, Istvan Czikora, Qiang Yue, Jürg Hamacher, Armanda Formigao Gameiro, Tiffany L. Thai, Supriya Sridhar, Huabo Su, Waheed Shabbir, Maria Loose, Mohammed Aufy, Billie Jeanne Duke, Abdel A. Alli, Iryna Lebedyeva, Trinad Chakraborty, Otor Al-Khalili, Rosa Lemmens-Gruber, Bernhard Fischer, Susan Tzotzos
Publikováno v:
Journal of Biological Chemistry. 291:23440-23451
Regulation of the epithelial sodium channel (ENaC), which regulates fluid homeostasis and blood pressure, is complex and remains incompletely understood. The TIP peptide, a mimic of the lectin-like domain of TNF, activates ENaC by binding to glycosyl
Autor:
Alexander Holzner, Bernhard Fischer, Helmut Pietschmann, Hendrik Fischer, Rudolf Lucas, Waheed Shabbir, Susan Tzotzos, Parastoo Scherbaum-Hazemi, Martin Kraihammer, Rosa Lemmens-Gruber, Mohammad Aufy, Istvan Czikora, Minela Bedak, Anita Willam
Publikováno v:
Biochemical Pharmacology. 98:740-753
Dysfunction of the epithelial sodium channel (ENaC), which regulates salt and water homeostasis in epithelia, causes several human pathological conditions, including pulmonary oedema. This is a potentially lethal complication of acute lung injury at
Autor:
Hendrik Fischer, Bernhard Fischer, Robert Hermann, Hermann Mascher, Richard Schwameis, Sandra Eder, Susan Tzotzos, Markus Zeitlinger, Helmut Pietschmann, Rudolf Lucas
Publikováno v:
The Journal of Clinical Pharmacology. 54:341-350
The diagnosis acute respiratory distress syndrome (ARDS) describes a type of acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, pulmonary edema, increased lung weight, and loss of aerated lung tissue.1,2 AR
Autor:
Hendrik Fischer, Sabrina Geppert, Anita Willam, Rosa Lemmens-Gruber, Heinrich Evanzin, Waheed Shabbir, Mohammed Aufy, Bernhard Fischer, Rudolf Lucas, Sabine Chytracek, Susan Tzotzos, Istvan Czikora, Helmut Pietschmann
Publikováno v:
Frontiers in Pharmacology
The synthetically produced cyclic peptides solnatide (a.k.a. TIP or AP301) and its congener AP318, whose molecular structures mimic the lectin-like domain of human tumor necrosis factor (TNF), have been shown to activate the epithelial sodium channel
Autor:
Parastoo Scherbaum-Hazemi, Susan Tzotzos, Helmut Pietschmann, Rudolf Lucas, Bernhard Fischer, Rosa Lemmens-Gruber, Hendrik Fischer, Waheed Shabbir
Publikováno v:
Molecular Pharmacology. 84:899-910
AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis factor lectin-like domain (TIP domain) sequence, is currently being developed as a treatment for lung edema and has been shown to reduce extravascular lung water a