Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Susan, Summerhill"'
Autor:
Gary Salmon, Harvey Wong, Maxine Norman, Adrian Barnard, Aihe Zhou, Julie Hawkins, Benjamin Fauber, Adam R. Johnson, Arunima Ganguli, Yuzhong Deng, Susan Summerhill, Kirk Robarge, Celine Eidenschenk, Wenjun Ouyang, Christine Everett, Jianhua Cao, Wei Tang, Hank La, Alberto Gobbi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2907-2912
The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9c3898f9ddd336ebaff802da33874c
https://doi.org/10.1016/j.bmcl.2015.05.055
https://doi.org/10.1016/j.bmcl.2015.05.055
Autor:
Adam R. Johnson, Justin Lesch, Christine Everett, Harvey Wong, Susan Summerhill, Peter Lockey, Arunima Ganguli, Julie Hawkins, Benjamin Fauber, Jason DeVoss, Olivier Rene, Maxine Norman, Hank La, Yuzhong Deng, Celine Eidenschenk, Wenjun Ouyang, Alberto Gobbi
Publikováno v:
Journal of Medicinal Chemistry. 58:5308-5322
Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151b339a4b74d195a593caace65f3802
https://doi.org/10.1021/acs.jmedchem.5b00597
https://doi.org/10.1021/acs.jmedchem.5b00597
Autor:
Yuzhong Deng, Susan Summerhill, Benjamin Fauber, Maxine Norman, Alberto Gobbi, Adrian Barnard, Kerry Chapman, Adam R. Johnson, Olivier Rene, Harvey Wong, Christine Everett, Hank La, Gary Salmon, Celine Eidenschenk
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(18)
Modification of the δ-sultam ring of RORc inverse agonist 2 led to the discovery of more polar oxa-sultam 65. The less lipophilic inverse agonist (65) displayed high potency in a biochemical assay, which translated into inhibition of IL-17 productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fca3900a945d8ef4376c70bfb26aaf7
https://pubmed.ncbi.nlm.nih.gov/27524313
https://pubmed.ncbi.nlm.nih.gov/27524313
Publikováno v:
International Immunopharmacology. 13:225-231
LPS inhalation was used to investigate whether sputum supernatant post-LPS challenge increases neutrophil chemotactic activity and to elucidate the role of CXCR1/CXCR2 signalling in this process. 14 healthy non-smoking subjects inhaled 30μg of LPS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce20371516f5d84bca41925a371b2f45
https://doi.org/10.1016/j.intimp.2012.04.008
https://doi.org/10.1016/j.intimp.2012.04.008
Autor:
Paul Alan Glossop, Susan Summerhill, Hao Liu, Sheena Patel, Lyn H. Jones, Nick Clarke, Amy S. Kenyon, Rachel Osborne
Publikováno v:
Journal of Medicinal Chemistry. 54:6998-7002
Following interrogation of a wide-ligand profile database, a nonselective norepinephrin reuptake inhibitor was converted into a novel muscarinic antagonist using two medicinal chemistry transformations (M3/NRI selectivity of >1000). Conjugation to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7583d1241fdf5a93ebc8010c3725cc83
https://doi.org/10.1021/jm2007535
https://doi.org/10.1021/jm2007535
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 24:247-255
Long acting β(2)-adrenoceptor agonists as exemplified by salmeterol and formoterol, exhibit reassertion behaviour in isolated airway preparations. This phenomenon is the inhibition of relaxation by a β(2)-antagonist (e.g. sotalol), followed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703426ed597d3457133fc92fec323cf3
https://doi.org/10.1016/j.pupt.2010.11.004
https://doi.org/10.1016/j.pupt.2010.11.004
Autor:
Timothy Stroud, Susan Summerhill, Roshini Nagendra, Christelle Perros-Huguet, Michael A. Trevethick
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:189-197
The aim was to establish a robust, 96-well, cell-based assay to assess the potency and persistence of action of agonists acting at human recombinant beta(2) adrenoceptors expressed in CHO (Chinese Hamster Ovary) cells and to compare this with publish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e6eed84b44988f66d042ab7fcf3520
https://doi.org/10.1016/j.vascn.2008.06.003
https://doi.org/10.1016/j.vascn.2008.06.003
Autor:
Rachel, Osborne, Nick, Clarke, Paul, Glossop, Amy, Kenyon, Hao, Liu, Sheena, Patel, Susan, Summerhill, Lyn H, Jones
Publikováno v:
Journal of medicinal chemistry. 54(19)
Following interrogation of a wide-ligand profile database, a nonselective norepinephrin reuptake inhibitor was converted into a novel muscarinic antagonist using two medicinal chemistry transformations (M3/NRI selectivity of1000). Conjugation to a β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba5b8facd8976594e8ecbae0d213cad7
https://pubmed.ncbi.nlm.nih.gov/21863888
https://pubmed.ncbi.nlm.nih.gov/21863888
Autor:
Iain Kilty, Dave Singh, Jonathan Plumb, Raminder Aul, Kate Howarth, Sheena Patel, Susan Summerhill
Publikováno v:
B21. NEUTROPHIL STUDIES IN ASTHMA AND COPD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a862c3c30051e4039768db496625331f
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2551
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2551
Autor:
Emilio F. Stuart, Nick Clarke, Maria Stanley, Michele Coghlan, Matthew Strawbridge, Susan Summerhill, Mike Yeadon, Sheena Patel, Christelle Perros-Huguet, Mike Trevethick, Stuart Marshall
Publikováno v:
A45. BRONCHODILATORS FOR COPD: OLD FAITHFULS AND NOVEL COMPOUNDS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ea5d7da0632c8acdba8d01b18a94de
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1607
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1607