Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Susan, Roomans"'
Autor:
Lydia Y. W. Lee, Aman Iqbal, Sahil Patel, Gordon Saxty, Carr Maria Grazia, Valerio Berdini, Keisha Hearn, Ildiko Maria Buck, Christopher William Murray, Kirsten V. Smith, Anne Cleasby, Paul N. Mortenson, Vanessa Martins, Joseph E. Coyle, Jayne Curry, Joanne M. Munck, Phillip J. Day, Susan Roomans, James Edward Harvey Day, Emiliano Tamanini, Lee William Page
Publikováno v:
ACS Medicinal Chemistry Letters. 6:798-803
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cc4aabaaba0c23f9593552e8263dd9
https://doi.org/10.1021/acsmedchemlett.5b00143
https://doi.org/10.1021/acsmedchemlett.5b00143
Autor:
Terry P. Kenakin, David W. Gray, Jim Coote, Alan Wise, Heather Giles, Cynthia L. Burns-Kurtis, Sara Pritchard, Noel Lloyd Staton, Jason D. Brown, Richard J. Wilson, Valerie Morrison, Susan Roomans, Sharron A. Rhodes, Kerri Ann Cartwright, Gerard Martin Paul Giblin, Jannatara Chowdhury, Vanessa J. Shield
Publikováno v:
British Journal of Pharmacology. 148:326-339
1. N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl}benzene sulphonamide (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. 2. At r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf558d34ada4757fe816bf62db7fd827
https://doi.org/10.1038/sj.bjp.0706726
https://doi.org/10.1038/sj.bjp.0706726
Autor:
Ian B. Campbell, George E. Tranter, Ashley Paul Hancock, Christopher R Molloy, Karl Huffman, Gary I. Mills, Philip Charles Box, Ann Louise Walker, Gerard Martin Paul Giblin, Susan R. Doctrow, Susan Roomans, Bernard Malfroy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1367-1370
A series of novel manganese(III) complexes is described based on a 6,6'-bis(2-hydroxyphenyl)-2,2'-bipyridine template. These complexes show superoxide dismutase and catalase activity. The effect of the aromatic substitution pattern on the SAR is desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571c04c73231f3fe42a9ae7f2d56f34
https://doi.org/10.1016/s0960-894x(01)00217-7
https://doi.org/10.1016/s0960-894x(01)00217-7
Autor:
Andrew J. Brown, William L. Mitchell, Susan Roomans, Gerard Martin Paul Giblin, Martin E. Swarbrick, Neville Hubert Nicholson, Robert Gleave, Lee William Page, Carl Haslam, Paul Goldsmith, Brian Peter Slingsby, Sadhana Patel, Paul John Beswick
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
A series of 3-amino-6-aryl-pyridazines have been identified as CB2 agonists with high efficacy and selectivity against the CB1 receptor. Details of the investigation of structure–activity relationships (SAR) are disclosed, which led to the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e97af63c93c5dc03f9e239e7525400
https://pubmed.ncbi.nlm.nih.gov/20005703
https://pubmed.ncbi.nlm.nih.gov/20005703
Autor:
Richard J, Wilson, Gerard M P, Giblin, Susan, Roomans, Sharron A, Rhodes, Kerri-Ann, Cartwright, Vanessa J, Shield, Jason, Brown, Alan, Wise, Jannatara, Chowdhury, Sara, Pritchard, Jim, Coote, Lloyd S, Noel, Terry, Kenakin, Cynthia L, Burns-Kurtis, Valerie, Morrison, David W, Gray, Heather, Giles
Publikováno v:
British journal of pharmacology. 148(3)
1. N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl}benzene sulphonamide (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. 2. At r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17608116c111bff1a5567b5e2886c441
https://pubmed.ncbi.nlm.nih.gov/16604093
https://pubmed.ncbi.nlm.nih.gov/16604093