Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Susan, Mackem"'
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the
Externí odkaz:
https://doaj.org/article/7c9a9b83afdc4ea8afaf6d100fd069b1
Autor:
Sounak Sahu, Mary E. Albaugh, Betty K. Martin, Nimit L. Patel, Lisa Riffle, Susan Mackem, Joseph D. Kalen, Shyam K. Sharan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Signaling pathways play an important role in cell fate determination in stem cells and regulate a plethora of developmental programs, the dysregulation of which can lead to human diseases. Growth factors (GFs) regulating these signaling path
Externí odkaz:
https://doaj.org/article/e78755a689b14a6bb26033fa5a7a037d
Autor:
Bau-Lin Huang, Anna Trofka, Aki Furusawa, Jacqueline L. Norrie, Adam H. Rabinowitz, Steven A. Vokes, M. Mark Taketo, Jozsef Zakany, Susan Mackem
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and j
Externí odkaz:
https://doaj.org/article/b589df54b71a442db003ba86c874cc67
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Peyman Zarrineh, Jean Denis Benazet, Brandon Chacon, Ausra Girdziusaite, Angela Morabito, Jianjian Zhu, Susan Mackem, Terence Capellini, Nicoletta Bobola, Diane Dickel, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
During development cell fates are specified by tightly controlled gene expression programs. PBX TALE transcription factors control gene regulatory networks (GRN) that direct vertebrate tissue patterning and organ morphogenesis. How PBX1/2 proteins ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3b6289b67ce5c003d940fcaf337aa1
https://doi.org/10.1101/2022.03.08.483529
https://doi.org/10.1101/2022.03.08.483529
Publikováno v:
Developmental cell. 57(17)
Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal integration, is a paradigm for "morphogen" function, yet how Shh instructs distinct digit identities remains controversial. Here, we bypass the Shh requirement in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6709662cd841bf9ca055123c32b7ec
https://pubmed.ncbi.nlm.nih.gov/36099905
https://pubmed.ncbi.nlm.nih.gov/36099905
Autor:
Sounak Sahu, Mary E. Albaugh, Betty K. Martin, Nimit L. Patel, Lisa Riffle, Susan Mackem, Joseph D. Kalen, Shyam K. Sharan
Publikováno v:
Scientific reports. 12(1)
Signaling pathways play an important role in cell fate determination in stem cells and regulate a plethora of developmental programs, the dysregulation of which can lead to human diseases. Growth factors (GFs) regulating these signaling pathways ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2423674e72969ebf7395173285c007ee
https://pubmed.ncbi.nlm.nih.gov/35504930
https://pubmed.ncbi.nlm.nih.gov/35504930
Autor:
Susan Mackem, Bau-Lin Huang
Publikováno v:
Developmental dynamics : an official publication of the American Association of AnatomistsREFERENCES. 251(9)
Seminal work from John Fallon's lab has illuminated how digit identity determination involves ongoing late regulation and occurs progressively during phalanx formation. Complementary genetic analyses in mice and several papers in this special issue h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6273ea5584879c95f7f1f870ed63b83c
https://pubmed.ncbi.nlm.nih.gov/34811837
https://pubmed.ncbi.nlm.nih.gov/34811837
Autor:
Bau-Lin Huang, Susan Mackem
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123325 (2015)
During limb development, the interdigital mesenchyme has been proposed to play a signaling role instructing morphogenesis of different digit types, as well as undergoing programmed cell death necessary to free digits in animals not adapted for swimmi
Externí odkaz:
https://doaj.org/article/8cb4fa8c80eb4b5fad795b62a6248739
Summary Limb patterning by Sonic hedgehog (Shh) is among the most highly touted and studied models of “morphogen” function1. Yet how Shh instructs distinct digit types (index to little finger) remains controversial. Both spatial concentration gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd9e0a4642f4d5feb8440b00761254d
https://doi.org/10.1101/2020.05.28.122119
https://doi.org/10.1101/2020.05.28.122119
Autor:
Ravindra B. Chalamalasetty, Terry P. Yamaguchi, Amit Kumar, Susan Mackem, Mark W. Kennedy, Jianjian Zhu, Robert J. Garriock
Publikováno v:
Development
Despite the importance of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively little is known about its role in colon formation during embryogenesis. The development of the colon starts with the formation and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8318071e208a3944f6cb7faacc7398fc
https://europepmc.org/articles/PMC7174843/
https://europepmc.org/articles/PMC7174843/