Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Susan, Klaeger"'
1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer
Autor:
Philip D Greenberg, Eva K Verzani, Jennifer G Abelin, Alex M Jaeger, Tyler Jacks, Andrew J Aguirre, Susan Klaeger, Zackery A Ely, Zachary J Kulstad, Sudarsana Addepalli, Karl Clauser, Kevin S Kapner, Connor J Hennessey, Miles Agus, Jennifer Su, Steven Carr, William Freed-Pastor
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8c9ce62a787d46bc806b7e8d7e0b414a
Autor:
Daniel Le, Kristin Leskoske, Hem Gurung, Ana Magalhaes, Samir Vaidya, Hang Xu, Yuxin Liang, Susan Klaeger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e8dd96b631dc4ae9becf6ebc82e67dbf
Autor:
Jennifer G. Abelin, Erik J. Bergstrom, Keith D. Rivera, Hannah B. Taylor, Susan Klaeger, Charles Xu, Eva K. Verzani, C. Jackson White, Hilina B. Woldemichael, Maya Virshup, Meagan E. Olive, Myranda Maynard, Stephanie A. Vartany, Joseph D. Allen, Kshiti Phulphagar, M. Harry Kane, Suzanna Rachimi, D. R. Mani, Michael A. Gillette, Shankha Satpathy, Karl R. Clauser, Namrata D. Udeshi, Steven A. Carr
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Patient samples are often available in limited amounts, restricting the number of possible omics analyses. Here the authors present MONTE, a workflow that enables serial HLA-I and HLA-II immunopeptidome, ubiquitylome, proteome, phosphoproteome, and a
Externí odkaz:
https://doaj.org/article/2cb22e1fb42e4c8ab1737bea5ee8836a
Autor:
Shanye Yin, Susan Klaeger, Vipheaviny A. Chea, Isabel P. Carulli, Suzanna Rachimi, Katharine E. Black, Michael Filbin, Lida P. Hariri, Rachel S. Knipe, Robert F. Padera, Jonathan D. Stevens, William J. Lane, Steven A. Carr, Catherine J. Wu, Edy Yong Kim, Derin B. Keskin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere respiratory illness is the most prominent manifestation of patients infected with SARS-CoV-2, and yet the molecular mechanisms underlying severe lung disease in COVID-19 affected patients still require elucidation. Human leukocyte
Externí odkaz:
https://doaj.org/article/ee4599fa483940c28a9eb682e3174098
Autor:
Shira Weingarten-Gabbay, Leah R. Pearlman, Da-Yuan Chen, Susan Klaeger, Hannah B. Taylor, Nicole L. Welch, Derin B. Keskin, Steven A. Carr, Jennifer G. Abelin, Mohsan Saeed, Pardis C. Sabeti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101910- (2022)
Summary: Immunopeptidome profiling of infected cells is a powerful technique for detecting viral peptides that are naturally processed and loaded onto class I human leukocyte antigens (HLAs-I). Here, we provide a protocol for preparing samples for im
Externí odkaz:
https://doaj.org/article/a80517e85925451787c3e331aa4a5355
Autor:
Mathias Wilhelm, Daniel P. Zolg, Michael Graber, Siegfried Gessulat, Tobias Schmidt, Karsten Schnatbaum, Celina Schwencke-Westphal, Philipp Seifert, Niklas de Andrade Krätzig, Johannes Zerweck, Tobias Knaute, Eva Bräunlein, Patroklos Samaras, Ludwig Lautenbacher, Susan Klaeger, Holger Wenschuh, Roland Rad, Bernard Delanghe, Andreas Huhmer, Steven A. Carr, Karl R. Clauser, Angela M. Krackhardt, Ulf Reimer, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The identification of HLA peptides by mass spectrometry is non-trivial. Here, the authors extended and used the wealth of data from the ProteomeTools project to improve the prediction of non-tryptic peptides using deep learning, and show their approa
Externí odkaz:
https://doaj.org/article/1610571c49f445ee8754bc881b81762b
Autor:
Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, Jonathan D. Stevens, Alan Y.L. Wong, J. Bryan Iorgulescu, Anna Y. Tarren, Vipheaviny A. Chea, Isabel P. Carulli, Camilla K. Lemvigh, Christina B. Pedersen, Ashley K. Gartin, Siranush Sarkizova, Kyle T. Wright, Letitia W. Li, Jason Nomburg, Shuqiang Li, Teddy Huang, Xiaoxi Liu, Lucas Pomerance, Laura M. Doherty, Annie M. Apffel, Luke J. Wallace, Suzanna Rachimi, Kristen D. Felt, Jacquelyn O. Wolff, Elizabeth Witten, Wandi Zhang, Donna Neuberg, William J. Lane, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu, Derin B. Keskin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel c
Externí odkaz:
https://doaj.org/article/60397b52dbf342a38a8b4cfb3371eac6
Autor:
Mathias Wilhelm, Daniel P. Zolg, Michael Graber, Siegfried Gessulat, Tobias Schmidt, Karsten Schnatbaum, Celina Schwencke-Westphal, Philipp Seifert, Niklas de Andrade Krätzig, Johannes Zerweck, Tobias Knaute, Eva Bräunlein, Patroklos Samaras, Ludwig Lautenbacher, Susan Klaeger, Holger Wenschuh, Roland Rad, Bernard Delanghe, Andreas Huhmer, Steven A. Carr, Karl R. Clauser, Angela M. Krackhardt, Ulf Reimer, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/87d333c82515442e96dbcc20baf4c35f
Autor:
Nicoletta Cieri, Nidhi Hookeri, Kari Stromhaug, Jonathan Stevens, Kameron Kooshesh, Susan Klaeger, Karl R. Clauser, Siranush Sarkizova, David A. Braun, Livius Penter, Giacomo Oliveira, Haesook T. Kim, William J. Lane, Shuqiang Li, Kenneth J. Livak, Vincent T. Ho, Jerome Ritz, Robert J. Soiffer, Derin B. Keskin, Chip Stewart, Alexander Gusev, Gad Getz, Catherine J. Wu
Publikováno v:
Blood. 140:4762-4764
Autor:
Kshiti Meera Phulphagar, Claudia Ctortecka, Alvaro Sebastian Vaca Jacome, Susan Klaeger, Eva K. Verzani, Gabrielle M. Hernandez, Namrata D. Udeshi, Karl R. Clauser, Jennifer G. Abelin, Steven A. Carr
Publikováno v:
bioRxiv
Comprehensive, in-depth identification of the human leukocyte antigen HLA-I and HLA-II tumor immunopeptidome can inform the development of cancer immunotherapies. Mass spectrometry (MS) is powerful technology for direct identification of HLA peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f313274303cd151b25fcb6257107086
https://europepmc.org/articles/PMC10054976/
https://europepmc.org/articles/PMC10054976/