Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Susan, Kelso"'
Autor:
Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
Publikováno v:
EMBO reports. 23
Autor:
Siobhan, O'Brien, Susan, Kelso, Zachary, Steinhart, Stephen, Orlicky, Monika, Mis, Yunhye, Kim, Sichun, Lin, Frank, Sicheri, Stephane, Angers
Publikováno v:
EMBO reports. 23(12)
FBXW7, which encodes a substrate-specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using
Autor:
Siobhan O’Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
FBXW7, which encodes a substrate specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564a9c72f6688e308a6e716fadfadfe0
https://doi.org/10.1101/2022.09.26.509608
https://doi.org/10.1101/2022.09.26.509608
Autor:
Dalia Naser, Michael V. Tarasca, Bruna Siebeneichler, Anna Schaefer, Harmeen K. Deol, Tyler G. B. Soule, Johnathan Almey, Susan Kelso, Gyana G. Mishra, Hilary Simon, Elizabeth M. Meiering
Publikováno v:
Angewandte Chemie International Edition. 61
Protein aggregation is central to aging, disease and biotechnology. While there has been recent progress in defining structural features of cellular protein aggregates, many aspects remain unclear due to heterogeneity of aggregates presenting obstacl
Publikováno v:
Structure. 30:1615-1625.e4
Autor:
Stephen Orlicky, Jasmin Coulombe-Huntington, Clint James, Ganna Posternak, Thierry Bertomeu, Susan Kelso, Almer M. van der Sloot, Derek F. Ceccarelli, Susan Moore, Xiaojing Tang, Frank Sicheri, Mike Tyers, Daniel J. St-Cyr, Anne Marinier
Publikováno v:
Science advances. 7(44)
Pharmacological control of the ubiquitin-proteasome system (UPS) is of intense interest in drug discovery. Here, we report the development of chemical inhibitors of the ubiquitin-conjugating (E2) enzyme CDC34A (also known as UBE2R1), which donates ac
Autor:
Gerald D. Gish, Stephen Orlicky, Derek F. Ceccarelli, Igor Kurinov, Frank Sicheri, Susan Kelso, Jonah Beenstock
Publikováno v:
Structure
Summary Skp2 and cyclin A are cell-cycle regulators that control the activity of CDK2. Cyclin A acts as an activator and substrate recruitment factor of CDK2, while Skp2 mediates the ubiquitination and subsequent destruction of the CDK inhibitor prot
Autor:
Simon Gravel, Sylvie Fraitag, Janie Charlebois, Jacek Majewski, Catherine Thieblemont, Rachel Conyers, Brigitte Bader-Meunier, Patrick Nitschke, Tenzin Gayden, Nada Jabado, Fernando E. Sepulveda, Paul G Ekert, Andrea Bajic, Mikko Taipale, Geneviève de Saint Basile, Daniel Schramek, Benedicte Neven, Jean-Sebastien Diana, Dong-Anh Khuong-Quang, Alain Fischer, David Michonneau, David Mitchell, Dzana Dervovic, Frank Sicheri, Maxime Battistella, Elvis Terci Valera, Alexandrine Garrigue, Stéphane Blanche, Despina Moshous, Hamid Nikbakht, Christopher McCormack, Rola Dali, Marianne Besnard, Jonathan Pratt, Nancy Hamel, Sharon Abish, Susan Kelso, H. Miles Prince, Christine Bole-Feysot, Van-Hung Nguyen, Frédéric Guerin, Leonie G. Mikael, William D. Foulkes
Publikováno v:
60th ASH Annual Meeting
60th ASH Annual Meeting, Dec 2019, San Diego, United States. pp.1569-1569, ⟨10.1182/blood-2018-99-120297⟩
60th ASH Annual Meeting, Dec 2019, San Diego, United States. pp.1569-1569, ⟨10.1182/blood-2018-99-120297⟩
Introduction Sub-cutaneous panniculitis T-cell lymphomas (SPTCL), a rare non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening activation of the immune system which adversely impacts survival. T-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a601162065e172c599edd4b92e0a3d9f
https://hal.archives-ouvertes.fr/hal-02366000
https://hal.archives-ouvertes.fr/hal-02366000
Autor:
Fernando E. Sepulveda, Geneviève de Saint Basile, Patrick Nitschke, Stéphane Blanche, Maxime Battistella, David Michonneau, Nada Jabado, Shriya Deshmukh, David Mitchell, Christine Bole-Feysot, Janie Charlebois, Bénédicte Neven, Hamid Nikbakht, Mikko Taipale, Paul G Ekert, Christopher McCormack, William D. Foulkes, Leonie G. Mikael, Alexandrine Garrigue, Dzana Dervovic, Nancy Hamel, Andrea Bajic, Simon Gravel, Despina Moshous, Sharon Abish, Frank Sicheri, Rachel Conyers, Van-Hung Nguyen, Frédéric Guerin, Susan Kelso, Sylvie Fraitag, H. Miles Prince, Jean-Sebastien Diana, Rola Dali, Marianne Besnard, Jonathan Pratt, Elvis Terci Valera, Dong-Anh Khuong-Quang, Catherine Thieblemont, Alain Fischer, Tenzin Gayden, Jacek Majewski, Brigitte Bader-Meunier, Daniel Schramek
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2018, 50 (12), pp.1650-1657. ⟨10.1038/s41588-018-0251-4⟩
Nature Genetics, Nature Publishing Group, 2018, 50 (12), pp.1650-1657. ⟨10.1038/s41588-018-0251-4⟩
Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune activation that adversely affects survival1,2. T cell immunoglobulin mucin 3 (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decc992cff58693351d8c1f26262c3ce
https://hal.archives-ouvertes.fr/hal-02365179
https://hal.archives-ouvertes.fr/hal-02365179
Autor:
Catherine Thieblemont, Janie Charlebois, Daniel Schramek, Jean-Sebastien Diana, Tenzin Gayden, Van-Hung Nguyen, Patrick Nitschke, Rachel Conyers, Nancy Hamel, Frédéric Guerin, Christine Bole-Feysot, Sylvie Fraitag, William D. Foulkes, Frank Sicheri, Leonie G. Mikael, Sharon Abish, Hamid Nikbakht, Rola Dali, Stéphane Blanche, Fernando E. Sepulveda, Geneviève de Saint Basile, Alain Fischer, Marianne Besnard, Christopher McCormack, Andrea Bajic, Susan Kelso, Jacek Majewski, H. Miles Prince, Simon Gravel, David Michonneau, Nada Jabado, Shriya Deshmukh, Brigitte Bader-Meunier, Maxime Battistella, Bénédicte Neven, Jonathan Pratt, Dong-Anh Khuong-Quang, Elvis Terci Valera, Dzana Dervovic, Paul G Ekert, Alexandrine Garrigue, Despina Moshous, David Mitchell, Mikko Taipale
Publikováno v:
Nature Genetics. 51:196-196
In the version of this article originally published, the main-text sentence “In three patients of European ancestry, we identified the germline variant encoding p.Ile97Met in TIM-3, which was homozygous in two (P12 and P13) and heterozygous in one