Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Susan, Glick"'
Publikováno v:
MedEdPORTAL, Vol 3 (2007)
Abstract Introduction In order to appropriately care for a patient who is homeless, physicians must recognize the significance of homelessness to health and respond to the unique challenges that homelessness presents. Unfortunately, medical students
Externí odkaz:
https://doaj.org/article/404b20b3994e4fe79f010a14f435de37
Autor:
Susan Glick
Publikováno v:
MedEdPORTAL, Vol 3 (2007)
Abstract Introduction Learning to care for vulnerable populations, including survivors of domestic violence, is an essential part of undergraduate and graduate medical education. While classroom instruction may increase learners' knowledge, it may no
Externí odkaz:
https://doaj.org/article/ac387a8e16ef4ef9bb7a64bf0987f5c0
Autor:
Jeffrey A. Robl, Michael Thomas, Mary Ann Pelleymounter, Brian Gemzik, Anthony V. Azzara, Brian J. Murphy, Sharon N. Bisaha, Helen E. Godonis, Daniel Longhi, Neil Flynn, William N. Washburn, Kenneth W. Rohrbach, Khehyong Ngu, Saleem Ahmad, Susan Harvey, Christine Huang, Evan B. Janovitz, Andres S. Hernandez, James Devenny, Hongwei Zhang, Lisa Zhang, Susan Glick, Suzanne Rooney, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 59:8848-8858
The potent MCHR1 in vitro and in vivo antagonist activity of a series of cyclic tertiary alcohols derived from compound 2b is described. Subsequent pharmacokinetic and pharmacodynamic studies identified BMS-814580 (compound 10) as a highly efficaciou
Autor:
Neil Flynn, Mary Jane Cullen, Hongwei Zhang, Wei Wang, Susan Glick, Lisa Zhang, Jeffrey A. Robl, Pratik Devasthale, Andres S. Hernandez, Christian Caporuscio, Brian J. Murphy, Suzanne Rooney, Ning Huang, Mary Ann Pelleymounter, Kenneth W. Rohrbach, Kishore Renduchintala, Anthony V. Azzara, Helen E. Godonis, Yi-Xin Li, Radhakrishnan Sridhar, Michael Thomas, Susan Harvey, Paul Stetsko, Mary F. Grubb, Chris Freeden, Fang Moore, Christine Huang, James Devenny, Daniel Longhi, William N. Washburn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2793-2799
Our investigation of the structure–activity and structure–liability relationships for dihydropyrrolopyrazol-6-one MCHR1 antagonists revealed that off-rate characteristics, inferred from potencies in a FLIPR assay following a 2 h incubation, can i
Autor:
Jeffrey A. Robl, Guohua Zhao, Joel C. Barrish, Bei Wang, Brad D. Maxwell, Christian Caporuscio, Hongwei Zhang, James Devenny, Mary F. Grubb, Zhenghua Wang, Suzanne Rooney, James Mignone, Lisa Zhang, Brian J. Murphy, Wei Wang, Daniel Longhi, William N. Washburn, Kenneth W. Rohrbach, Evan B. Janovitz, Mark C. Manfredi, Mary Ann Pelleymounter, Michael Thomas, Hong Yang, Paul Stetsko, Saleem Ahmad, Atsu Apedo, Mary Jane Cullen, Brian Gemzik, Ning Huang, Chris Freeden, Susan Harvey, Anthony V. Azzara, Khehyong Ngu, Christine Huang, Rulin Zhao, Susan Glick, Neil Flynn, Pratik Devasthale, Andres S. Hernandez, Helen E. Godonis
Publikováno v:
Journal of Medicinal Chemistry. 57:7509-7522
Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a challenge. Our finding that a basic moiety is not required for MCHR1 antagonists to achieve high affinity allowed us
Autor:
Saleem, Ahmad, William N, Washburn, Andres S, Hernandez, Sharon, Bisaha, Khehyong, Ngu, Wei, Wang, Mary Ann, Pelleymounter, Daniel, Longhi, Neil, Flynn, Anthony V, Azzara, Kenneth, Rohrbach, James, Devenny, Suzanne, Rooney, Michael, Thomas, Susan, Glick, Helen, Godonis, Susan, Harvey, Hongwei, Zhang, Brian, Gemzik, Evan B, Janovitz, Christine, Huang, Lisa, Zhang, Jeffrey A, Robl, Brian J, Murphy
Publikováno v:
Journal of medicinal chemistry. 59(19)
The potent MCHR1 in vitro and in vivo antagonist activity of a series of cyclic tertiary alcohols derived from compound 2b is described. Subsequent pharmacokinetic and pharmacodynamic studies identified BMS-814580 (compound 10) as a highly efficaciou
Autor:
Michael Thomas, P. Gregory, Mary Ann Pelleymounter, L. Watson, V. Wang, Kenneth W. Rohrbach, Susan Glick, E. N. Fung, J. Antel
Publikováno v:
Diabetes, Obesity and Metabolism. 14:555-564
Aim: To test the antidiabetic efficacy of ibipinabant, this new cannabinoid receptor 1 (CB1) antagonist was compared with food-restriction-induced weight loss, rosiglitazone (4 mg/kg) and rimonabant (3 and 10 mg/kg), using parameters of glycaemic con
Autor:
Brian J. Murphy, James Devenny, Suzanne Rooney, Jagannath Selvaraj, James Mignone, Susan Glick, Sridhar Radhakrishnan, Helen E. Godonis, Neil Flynn, Rajesh Kuppusamy, Jayanthi Dhanapal, Mary Ann Pelleymounter, Chris Freeden, Pratik Devasthale, Daniel Longhi, William N. Washburn, Ning Huang, Christian Caporuscio, Mary F. Grubb, Paul Stetsko, Kenneth W. Rohrbach, Mary Jane Cullen, Christine Huang, Wei Wang, Susan Harvey, Hongwei Zhang, Lisa Zhang, Michael Thomas, Jeffrey A. Robl, Kishore Renduchintala, Anthony V. Azzara
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(20)
Non-basic azolotriazinones were explored using an empirical free brain exposures-driven approach to identify potent MCHR1 antagonists for evaluation in in vivo efficacy studies. An optimized lead from this series, 1j (rMCHR1 Ki=1.8 nM), demonstrated
Publikováno v:
New England Journal of Medicine. 352:919-924
A 48-year-old airline mechanic from Belize presented to the emergency department with fever and altered mental status. Two weeks earlier, fever, myalgias, and dry cough had developed. Maximal daily temperatures reached 41.1°C, and one week later he
Autor:
Rongwei Fu, Craig A Umscheid, Meera Viswanathan, Jeanne Marie Guise, Evelyn P Whitlock, Jonathan Treadwell, Pua Motu'apuaka, Christine Chang, Robin Paynter, Johanna Anderson, Susan Glick, Thomas A Trikalinos, Elise Berliner
Publikováno v:
Journal of clinical epidemiology. 67(11)
Objectives The purpose of this Agency for Healthcare Research and Quality Evidence-based Practice Center methods white paper was to outline approaches to conducting systematic reviews of complex multicomponent health care interventions. Study Design