NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.

Autor: Perry CE; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Halawani SM; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Mukherjee S; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ngaba LV; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lieu M; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lee WD; Department of Chemistry, Princeton University, Princeton, New Jersey, USA., Davis JG; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Adzika GK; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bebenek AN; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bazianos DD; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chen B; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mercado-Ayon E; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Flatley LP; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Suryawanshi AP; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ho I; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Rabinowitz JD; Department of Chemistry, Princeton University, Princeton, New Jersey, USA., Serai SD; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Radiology and., Biko DM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Radiology and., Tamaroff J; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Pediatric Endocrinology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., DeDio A; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Wade K; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lin KY; Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Livingston DJ; Metro International Biotech, Worcester, Massachusetts, USA., McCormack SE; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lynch DR; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Baur JA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Jul 18; Vol. 9 (16). Date of Electronic Publication: 2024 Jul 18.