Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Surya Sankuratri"'
Autor:
Benny Chain, Jack Arnold, Samia Akthar, Michael Brandt, David Davis, Mahdad Noursadeghi, Thabo Lapp, Changhua Ji, Surya Sankuratri, Yanjing Zhang, Lata Govada, Emmanuel Saridakis, Naomi Chayen
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128381 (2015)
The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by passive or active immunisation offers one very selective strategy for intervention. In this
Externí odkaz:
https://doaj.org/article/2d4e5a257247431cb2a36a05fa62c086
Autor:
Denise Teoh, Han Ma, Erhard Kopetzki, Zi Zong Ho, Changhua Ji, Sandhya Bohini, Konduru S. R. Sastry, Klaus Klumpp, Jennifer Cano, Stefan Ries, Georg Tiefenthaler, Surya Sankuratri, Antonio Bertoletti, Tenny Tang, Antony Chen, Paul A. MacAry, Patrick T F Kennedy
Publikováno v:
Hepatology. 56:2027-2038
During antiviral therapy, specific delivery of interferon-α (IFNα) to infected cells may increase its antiviral efficacy, trigger a localized immune reaction, and reduce the side effects caused by systemic administration. Two T-cell receptor-like a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a8398a0dbcc5313b48bfa28cc01118
https://doi.org/10.1002/hep.25875
https://doi.org/10.1002/hep.25875
Autor:
Cheng-I. Mau, Andreas Jekle, Ferenc Makra, Surya Sankuratri, Paul Weller, André deRosier, Eun Kyung Lee, Gabriel Stephen Deems, Gabrielle Heilek, David Mark Rotstein, Changhua Ji, Shelley K. Gleason, Christine E. Brotherton-Pleiss, Marianna Dioszegi, Lubov Filonova, Lina Setti, Pamela Berry, Alejandra Trejo-Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5401-5406
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12820458536333a16236817f9aa665
https://doi.org/10.1016/j.bmcl.2009.07.122
https://doi.org/10.1016/j.bmcl.2009.07.122
Autor:
Rosa Nguyen, Andreas Jekle, Gabrielle Heilek, Nick Cammack, Surya Sankuratri, Changhua Ji, Mei Jun Yan, Erhard Kopetzki, Eugene Chow
Publikováno v:
Antiviral Research. 83:257-266
Resistance to antiretroviral drugs is a common problem in the treatment of HIV-1-infected patients. To overcome resistance, we generated a novel, bifunctional HIV-1 entry inhibitor by combining the anti-CD4 monoclonal antibody (mAb) 6314 with a fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3c0e3fab30e8d53d06d19a45d22e32
https://doi.org/10.1016/j.antiviral.2009.06.005
https://doi.org/10.1016/j.antiviral.2009.06.005
Autor:
David Mark Rotstein, Changhua Ji, Rama K. Kondru, Marianna Dioszegi, Surya Sankuratri, Tara Mirzadegan, Jun Zhang
Publikováno v:
Molecular Pharmacology. 73:789-800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A large number of small-molecule CCR5 antagonists have been reported that show potent activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed924f54529ba393cdaa7997b6642bb
https://doi.org/10.1124/mol.107.042101
https://doi.org/10.1124/mol.107.042101
Autor:
Gabrielle Heilek-Snyder, Jun Zhang, Changhua Ji, Gunthar Achhammer, Nick Cammack, Steven Challand, Ralf Schumacher, Monika Baehner, Surya Sankuratri, Andreas Jekle, Sandra Kroetz, Michael Brandt, Lisa Zautke, Stephan Schwoerer, Marianna Dioszegi, Yun Chen
Publikováno v:
Antiviral Research. 74:125-137
To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed38cb9db5052ebbfe98f57a06c9250
https://doi.org/10.1016/j.antiviral.2006.11.003
https://doi.org/10.1016/j.antiviral.2006.11.003
Autor:
Changhua Ji, Nick Cammack, Eileen Rao, Jun Zhang, Marianna Dioszegi, Rama K. Kondru, André deRosier, Surya Sankuratri, Michael Brandt, Stephan Schwoerer, Eva Chan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:1386-1397
Six mouse anti-human CCR5 monoclonal antibodies (mAbs) that showed potent antiviral activities were identified from over 26,000 mouse hybridomas. The epitopes for these mAbs were determined by using various CCR5 mutants, including CCR5/CCR2B chimeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10e77713ca764a1a46cc21f622da3a9
https://doi.org/10.1128/aac.01302-06
https://doi.org/10.1128/aac.01302-06
Publikováno v:
SLAS Discovery. 11:65-74
In the current study, a novel coreceptor-specific cell-cell fusion (CCF) assay system is reported. The system possesses the following features: dual CCR5-dependent and CXCR4-dependent CCF assays, all stable cell lines, inducible expression of gp160 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd821705f1e44ab5c89a6055fddf572
https://doi.org/10.1177/1087057105282959
https://doi.org/10.1177/1087057105282959
Autor:
Gabrielle Heilek, Fernando Padilla, Surya Sankuratri, Lubov Filonova, Nicole Manser, Gabriel Stephen Deems, David Mark Rotstein, André deRosier, Paul Weller, Andreas Jekle, Marianna Dioszegi, Pamela Berry, Changhua Ji
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(11)
Elaboration of our previously disclosed spiropiperidine template led to the development of a series of novel CCR5 antagonists. Results of SAR exploration and preliminary lead characterization are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce4a4510bc6f190a2ead5798131f0f8
https://pubmed.ncbi.nlm.nih.gov/20457517
https://pubmed.ncbi.nlm.nih.gov/20457517
Autor:
André deRosier, David G. Loughhead, David Mark Rotstein, Shelley K. Gleason, Eun Kyung Lee, Fernando Padilla, Lina Setti, Dick Cournoyer, Remy Lemoine, Cheng-I. Mau, Paul Weller, Andreas Jekle, Jutta Wanner, Pamela Berry, Chris Richard Melville, Marianna Dioszegi, Ann C. Petersen, Surya Sankuratri, Jason Manka, Changhua Ji, Lin Xiao-Fa, Lijing Chen, Gabrielle Heilek, Lubov Filonova
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757bbb465169e0977e2a95f17e17d1e6
https://pubmed.ncbi.nlm.nih.gov/20417098
https://pubmed.ncbi.nlm.nih.gov/20417098