Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Surya D, Aggarwal"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Using chromosomal barcoding, we observed that >97% of the Streptococcus pneumoniae (Spn) population turns over in the lung within 2 days post-inoculation in a murine model. This marked collapse of diversity and bacterial turnover was associa
Externí odkaz:
https://doaj.org/article/3869469cabf84458a8538ded23289d69
Autor:
Kristen L Lokken-Toyli, Surya D Aggarwal, Gavyn Chern Wei Bee, Wouter A A de Steenhuijsen Piters, Cindy Wu, Kenny Zhi Ming Chen, Cynthia Loomis, Debby Bogaert, Jeffrey N Weiser
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012111 (2024)
Infants are highly susceptible to invasive respiratory and gastrointestinal infections. To elucidate the age-dependent mechanism(s) that drive bacterial spread from the mucosa, we developed an infant mouse model using the prevalent pediatric respirat
Externí odkaz:
https://doaj.org/article/db147eb912cc4567a3877fe5b6dfb2b6
Autor:
Anne-Stéphanie Rueff, Renske van Raaphorst, Surya D. Aggarwal, Javier Santos-Moreno, Géraldine Laloux, Yolanda Schaerli, Jeffrey N. Weiser, Jan-Willem Veening
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Phenotypic variation is the phenomenon in which clonal cells display different traits even under identical environmental conditions. This plasticity is thought to be important for processes including bacterial virulence, but direct evidence
Externí odkaz:
https://doaj.org/article/e8c7dfd4d89b4c2a9b32de5868db46ec
Autor:
Jiaqi Zhu, Annie R Abruzzo, Cindy Wu, Gavyn Chern Wei Bee, Alejandro Pironti, Gregory Putzel, Surya D Aggarwal, Hannes Eichner, Jeffrey N Weiser
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011509 (2023)
Among the many oral streptococci, Streptococcus pneumoniae (Spn) stands out for the capacity of encapsulated strains to cause invasive infection. Spread beyond upper airways, however, is a biological dead end for the organism, raising the question of
Externí odkaz:
https://doaj.org/article/3439e2fd3a894feda38bad683a056ae3
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Capsule-switch mutants were compared to analyze how serotype affects the success of Streptococcus pneumoniae (Spn) during colonization and transmission. Strains of multiple serotypes were tested in highly susceptible infant mice, both singly
Externí odkaz:
https://doaj.org/article/d1460143100e4effb63ed74dd203024d
Autor:
Saigopalakrishna S. Yerneni, Sarah Werner, Juliana H. Azambuja, Nils Ludwig, Rory Eutsey, Surya D. Aggarwal, Peter C. Lucas, Nathanael Bailey, Theresa L. Whiteside, Phil G. Campbell, N. Luisa Hiller
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Extracellular vesicles (EVs) have recently garnered attention for their participation in host-microbe interactions in pneumococcal infections. However, the effect of EVs on the host immune system remain poorly understood. Our studies focus o
Externí odkaz:
https://doaj.org/article/daf0bbbac4384c3cb6fb8c58d8262fcc
Autor:
Surya D. Aggarwal, Jessica M. Gullett, Tara Fedder, J. Pedro F. Safi, Charles O. Rock, N. Luisa Hiller
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Adaptation of bacteria to their host environment is a key component of colonization and pathogenesis. As an essential component of bacterial membranes, fatty acid composition contributes to host adaptation.
Externí odkaz:
https://doaj.org/article/dc72b3001b8c4992b928d5199381fe64
Autor:
Alexandria J Hammond, Ulrike Binsker, Surya D Aggarwal, Mila Brum Ortigoza, Cynthia Loomis, Jeffrey N Weiser
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009158 (2021)
Binding of Streptococcus pneumoniae (Spn) to nasal mucus leads to entrapment and clearance via mucociliary activity during colonization. To identify Spn factors allowing for evasion of mucus binding, we used a solid-phase adherence assay with immobil
Externí odkaz:
https://doaj.org/article/d230cce3a6e3483ea2fe0a28d2481612
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008931 (2020)
Gram-positive bacteria employ an array of secreted peptides to control population-level behaviors in response to environmental cues. We review mechanistic and functional features of secreted peptides produced by the human pathogen Streptococcus pneum
Externí odkaz:
https://doaj.org/article/a6fd3b470126493b858430d0eafd794d
Autor:
Surya D Aggarwal, Rory Eutsey, Jacob West-Roberts, Arnau Domenech, Wenjie Xu, Iman Tajer Abdullah, Aaron P Mitchell, Jan-Willem Veening, Hasan Yesilkaya, N Luisa Hiller
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007328 (2018)
Streptococcus pneumoniae (pneumococcus) is an opportunistic pathogen that causes otitis media, sinusitis, pneumonia, meningitis and sepsis. The progression to this pathogenic lifestyle is preceded by asymptomatic colonization of the nasopharynx. This
Externí odkaz:
https://doaj.org/article/4124728df49c4f7db9a7031cbc7af6f0