Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Suruchi Mittal"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007769 (2019)
The Human Papillomavirus E7 oncoprotein plays an essential role in the development and maintenance of malignancy, which it achieves through targeting a number of critical cell control pathways. An important element in the ability of E7 to contribute
Externí odkaz:
https://doaj.org/article/f1e6c3732f794293b9e3b1ea64babdff
Autor:
Ketaki Ganti, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaić, Lawrence Banks
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3530-3551 (2015)
Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had a sole function to confer interaction with a defined set of cellular s
Externí odkaz:
https://doaj.org/article/028d97401366449fb303d6059bd08eff
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Supplementary Figure 3: Breast cancer cell lines (A) BT-474, (B) MCF-7 and (C) MDA-MB-231 were treated with anti-Notch1 MAb (602.101), MAPK inhibitor (PD98059), combination of MAb602.101 and PD98059 and appropriate controls (IgG and DMSO) and cell vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d135021075037b67053389f92b86f8d
https://doi.org/10.1158/1535-7163.22500864.v1
https://doi.org/10.1158/1535-7163.22500864.v1
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Supplementary Figure 1: A) Photomicrographs show representative immunohistochemical staining for the expression of cleaved Notch1 and pErk1/2 in breast cancer patient samples based on which they were further sub-divided into clNotch1highpErkhigh and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a87f5df6de847d67731f89528a4cfcc
https://doi.org/10.1158/1535-7163.22500870
https://doi.org/10.1158/1535-7163.22500870
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Supplementary Figure 4: Breast cancer cell lines were subjected to sphere formation in the presence of anti-Notch1 MAb602.101 (10microg/ml), 10microM MAPK inhibitor (PD98059), combination of MAb602.101 and PD98059 and appropriate controls (IgG and DM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e3a57b00c81bd5257ab5a82b1e608a
https://doi.org/10.1158/1535-7163.22500861
https://doi.org/10.1158/1535-7163.22500861
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Supplementary Figure 2: BT474 cells treated with anti-Notch1 MAb 602.101 (10microg/ml) and MEK inhibitor PD98059 (10microM), alone (A and C respectively) or together (D), for 48 hrs were subjected to real time PCR analysis using specified primer sets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3a1582f7304a0753401254e3da5280
https://doi.org/10.1158/1535-7163.22500867
https://doi.org/10.1158/1535-7163.22500867
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Aberrant activation of Notch and Ras pathways has been detected in breast cancers. A synergy between these two pathways has also been shown in breast cell transformation in culture. Yet, the clinical relevance of Notch–Ras cooperation in breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e432f10fac0e09ed12338bca39c681c
https://doi.org/10.1158/1535-7163.c.6536598.v1
https://doi.org/10.1158/1535-7163.c.6536598.v1
Autor:
Annapoorni Rangarajan, Rekha V. Kumar, Rajan R. Dighe, Manju C. Gowda, Sai A. Balaji, Ankur Sharma, Suruchi Mittal
Supplementary Materials and Methods and Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5acdb11135312a2ff1c604314cf76b
https://doi.org/10.1158/1535-7163.22500855
https://doi.org/10.1158/1535-7163.22500855
Autor:
Lawrence Banks, Suruchi Mittal
Publikováno v:
Mutation Research/Reviews in Mutation Research. 772:23-35
Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential for the development and maintenance of malignancy. Both proteins functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dd7f98148e3abcb10c5c7ec71c097d
https://doi.org/10.1016/j.mrrev.2016.08.001
https://doi.org/10.1016/j.mrrev.2016.08.001
Autor:
Paola Massimi, Lawrence Banks, Anita Szalmás, Suruchi Mittal, József Kónya, Om Basukala, Vjekoslav Tomaić
Publikováno v:
Journal of Virology
Activation of signaling pathways ensuring cell growth is essential for the proliferative competence of human papillomavirus (HPV)-infected cells. Tyrosine kinases and phosphatases are key regulators of cellular growth control pathways. A recently ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea024f40a9653d9d85e9fe6abedfda
https://doi.org/10.1128/jvi.00057-17
https://doi.org/10.1128/jvi.00057-17