Zobrazeno 1 - 10 of 91 pro vyhledávání: '"Surkyn M"'
1
Akademický článek
Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
Autor: Romanov-Michailidis F; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Hsiao CC; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Urner LM; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Jerhaoui S; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Surkyn M; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Miller B; Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Vos A; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Dominguez Blanco M; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bueters R; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Vinken P; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bekkers M; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Walker D; Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Pietrak B; Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Eyckmans W; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Dores-Sousa JL; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Joo Koo S; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Lento W; Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bauser M; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Philippar U; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium., Rombouts FJR; Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 May 11; Vol. 66 (9), pp. 6122-6148. Date of Electronic Publication: 2023 Apr 28.
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2
Akademický článek
Development of a Concise and Robust Route to a Key Fragment of MCL-1 Inhibitors via Stereoselective Defluoroborylation.
Autor: Jouffroy M; Chemical Process R&D, Discovery Process Research, Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340 Beerse, Belgium., Pye P; Chemical Process R&D, External Research and Development Capabilities, Janssen Research & Development LLC, 920 U.S. Route 202, P.O. Box 300, Raritan, New Jersey 08869, United States., Jerhaoui S; Discovery Science, Discovery Chemistry BE, Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340 Beerse, Belgium., Chen W; Chemical Process R&D, Discovery Process Research, Janssen Research & Development LLC, Spring House, Pennsylvania 19477, United States., Surkyn M; Discovery Science, Discovery Chemistry BE, Janssen Pharmaceutica N.V., Turnhoutseweg 30, 2340 Beerse, Belgium.
Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Feb 18; Vol. 87 (4), pp. 2136-2141. Date of Electronic Publication: 2021 Sep 27.
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3
Akademický článek
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.
Autor: Peschiulli A; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Oehlrich D; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Van Gool M; Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., Austin N; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Van Brandt S; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Surkyn M; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., De Cleyn M; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Vos A; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Tresadern G; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Rombouts FJR; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Macdonald GJ; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Moechars D; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Trabanco AA; Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., Gijsen HJM; Discovery Chemistry, Discovery Sciences, DMPK, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Dec 01; Vol. 13 (1), pp. 76-83. Date of Electronic Publication: 2021 Dec 01 (Print Publication: 2022).
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4
Akademický článek
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
Autor: Rombouts FJR; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Kusakabe KI; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Alexander R; Janssen Research & Development, Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States., Austin N; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Borghys H; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., De Cleyn M; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Dhuyvetter D; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Gijsen HJM; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Hrupka B; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Jacobs T; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Jerhaoui S; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Lammens L; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Leclercq L; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Tsubone K; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Ueno T; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Morimoto K; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Einaru S; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Sumiyoshi H; Shionogi Pharmaceutical Research Center, Ltd., 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan., Van den Bergh A; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Vos A; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Surkyn M; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Teisman A; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium., Moechars D; Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, Beerse B-2340, Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14175-14191. Date of Electronic Publication: 2021 Sep 23.
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5
Akademický článek
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
Autor: Bischoff FP; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: fbischof@its.jnj.com., Velter AI; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Minne G; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Pieters S; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berthelot D; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., De Cleyn M; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Gijsen HJM; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Macdonald G; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Surkyn M; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Brandt S; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Roosbroeck Y; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Zavattaro C; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Mercken M; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Austin N; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Dhuyvetter D; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Borghys H; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Ahmad I; Jubilant Biosys Ltd, Bangalore, Karnataka, India., Samanta SK; Jubilant Biosys Ltd, Bangalore, Karnataka, India.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Jul 15; Vol. 29 (14), pp. 1737-1745. Date of Electronic Publication: 2019 May 15.
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6
Akademický článek
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.
Autor: Oehlrich D; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Peschiulli A; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Tresadern G; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Van Gool M; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., Vega JA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., De Lucas AI; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., Alonso de Diego SA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain., Prokopcova H; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Austin N; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Van Brandt S; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Surkyn M; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., De Cleyn M; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Vos A; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Rombouts FJR; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Macdonald G; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Moechars D; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Gijsen HJM; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium., Trabanco AA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Jul 02; Vol. 10 (8), pp. 1159-1165. Date of Electronic Publication: 2019 Jul 02 (Print Publication: 2019).
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8
Akademický článek
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9
Akademický článek
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.
Autor: Gijsen HJM; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Alonso de Diego SA; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen-Cilag SA , C/Jarama 75A , 45007 Toledo , Spain., De Cleyn M; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., García-Molina A; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen-Cilag SA , C/Jarama 75A , 45007 Toledo , Spain., Macdonald GJ; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Martínez-Lamenca C; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Oehlrich D; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Prokopcova H; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Rombouts FJR; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Surkyn M; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen-Cilag SA , C/Jarama 75A , 45007 Toledo , Spain., Van Brandt S; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Van den Bossche D; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Van Gool M; Neuroscience Medicinal Chemistry, Janssen Research & Development , Janssen-Cilag SA , C/Jarama 75A , 45007 Toledo , Spain., Austin N; Discovery Sciences, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Borghys H; Discovery Sciences, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Dhuyvetter D; Discovery Sciences, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium., Moechars D; Neuroscience Biology, Janssen Research & Development , Janssen Pharmaceutica NV , Turnhoutseweg 30 , B-2340 Beerse , Belgium.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jun 28; Vol. 61 (12), pp. 5292-5303. Date of Electronic Publication: 2018 Jun 11.
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10
Akademický článek
A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.
Autor: Li, Yong1,2 (AUTHOR), He, Liujun1 (AUTHOR), Qin, Hongxia1 (AUTHOR) 17320489614@163.com, Liu, Yao1 (AUTHOR), Yang, Binxin1 (AUTHOR), Xu, Zhigang1 (AUTHOR), Yang, Donglin1 (AUTHOR) 17320489614@163.com
Publikováno v: Molecules. Jan2024, Vol. 29 Issue 2, p464. 12p.
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